Tolazoline hydrochloride
- Product Name
- Tolazoline hydrochloride
- CAS No.
- 59-97-2
- Chemical Name
- Tolazoline hydrochloride
- Synonyms
- tolavad;LaMbral;arterodyl;Tolazoline HCl;tolazolinechloride;TIMTEC-BB SBB000360;Priscol hydrochloride;2-BENZYL-2-IMIDAZOLINE;imidalinehydrochloride;PRISCOLINE HYDROCHLORIDE
- CBNumber
- CB2277815
- Molecular Formula
- C10H13ClN2
- Formula Weight
- 196.68
- MOL File
- 59-97-2.mol
Tolazoline hydrochloride Property
- Melting point:
- 172-176 °C
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO (Slightly, Heated), Methanol (Slightly)
- form
- Crystalline Powder
- color
- White to almost white
- Sensitive
- Hygroscopic
- Merck
- 14,9506
- Stability:
- Hygroscopic
- CAS DataBase Reference
- 59-97-2(CAS DataBase Reference)
- EPA Substance Registry System
- Tolazoline hydrochloride (59-97-2)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T3791
- Product name
- Tolazoline Hydrochloride
- Packaging
- 5G
- Price
- $69
- Updated
- 2024/03/01
- Product number
- B21764
- Product name
- 2-Benzyl-2-imidazoline hydrochloride, 99%
- Packaging
- 25g
- Price
- $31.65
- Updated
- 2024/03/01
- Product number
- B21764
- Product name
- 2-Benzyl-2-imidazoline hydrochloride, 99%
- Packaging
- 100g
- Price
- $90
- Updated
- 2021/12/16
- Product number
- 18865
- Product name
- Tolazoline (hydrochloride)
- Purity
- ≥95%
- Packaging
- 5g
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 18865
- Product name
- Tolazoline (hydrochloride)
- Purity
- ≥95%
- Packaging
- 10g
- Price
- $50
- Updated
- 2024/03/01
Tolazoline hydrochloride Chemical Properties,Usage,Production
Chemical Properties
Pale Yellow Crystalline Solid
Originator
Priscoline,Ciba,US,1948
Uses
a-adrenergic antagonist. A peripheral vasodilator
Uses
Αn α-adrenergic antagonist. A peripheral vasodilator.
Uses
adrenergic blocker
Definition
ChEBI: Tolazoline hydrochloride is a member of benzenes.
Manufacturing Process
The phenyl-acetiminoether hydrochloride of the formula from 12 parts of benzylcyanide and ethanol and HCl is mixed with 8 parts of ethylenediamine hydrate which has been diluted with little alcohol, whereby the crystals go into solution. The whole is then heated on the water-bath until the ammonia odor has disappeared, cooled, concentrated caustic potash solution added, and the separated oil extracted with ether. The solution is dried with potassium carbonate and potassium hydroxide. After evaporation a pale oil is left which distills at 147°C under a pressure of 9 mm and which solidifies in the condenser to a white crystalline mass. The yield amounts to 90% of the theory. The hydrochloride melts at 168° to 170°C.
brand name
Tolazoline is INN and BAN.
Therapeutic Function
Vasodilator
Safety Profile
Poison by ingestion, intravenous, and intraperitoneal routes. Human systemic effects by intravenous route: change in heart rate, sweating, ulceration or bleeding from duodeum, ulceration or bleeding from small intestine, unspecified vascular effects. When heated to decomposition it emits very toxic fumes of NO, and HCl.
Veterinary Drugs and Treatments
flipping of lips); piloerection;
clear lacrimal & nasal discharge; muscle fasciculations;
apprehensiveness
Uses/Indications
Tolazoline is approved and indicated for the reversal of effects associated
with xylazine in horses. It has also been used for this purpose
in a variety of other species as well, but less safety and efficacy data
is available.
In humans, the primary uses for tolazoline are: treatment of persistent
pulmonary hypertension in newborns, adjunctive treatment
and diagnosis
Tolazoline hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Tolazoline hydrochloride Suppliers
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View Lastest Price from Tolazoline hydrochloride manufacturers
- Product
- Tolazoline hydrochloride 59-97-2
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%~101%,USP43
- Supply Ability
- 200kg/month
- Release date
- 2021-06-23
- Product
- Tolazoline hydrochloride 59-97-2
- Price
- US $1.00-1.00/KG
- Min. Order
- 25KG
- Purity
- 99.5%
- Supply Ability
- 5000KG/th
- Release date
- 2023-06-13
- Product
- Tolazoline hydrochloride 59-97-2
- Price
- US $50.70/Kg/Bag
- Min. Order
- 10g
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2021-07-23