DISTAMYCIN A HYDROCHLORIDE

Product Name: DISTAMYCIN A HYDROCHLORIDE
CAS No.: 6576-51-8
Chemical Name: DISTAMYCIN A HYDROCHLORIDE
Synonyms: fi6426;herperal;MEN-10399;DISTAMYCIN A HCL;estalimicinaclorhidrato;stallimycinhydrochloride;DISTAMYCIN A HYDROCHLORIDE;distamycin A hydrochloride from*streptomyces dist;DISTAMYCIN A HYDROCHLORIDE FROM*STREPTOM YCES DISTAL;Distamycin A hydrochloride from Streptomyces distallicus
CBNumber: CB9316227
Molecular Formula: C22H28ClN9O4
Formula Weight: 517.97
MOL File: 6576-51-8.mol

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DISTAMYCIN A HYDROCHLORIDE Property

Melting point:: 184-187° (Arcamone, 1967). Also reported as 189-193° from ethanol-ethyl acetate (Bialer)
storage temp.: −20°C

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Safety

Hazard Codes: Xi
Risk Statements: 43
Safety Statements: 36/37
WGK Germany: 3
RTECS: WZ7110000
Toxicity: LD50 in mice (mg/kg): 75 i.v.; 500 i.p. (DiMarco)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0010151
Product name: DISTAMYCIN A HYDROCHLORIDE
Purity: 95.00%
Packaging: 5MG
Price: $498.26
Updated: 2021/12/16

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DISTAMYCIN A HYDROCHLORIDE Chemical Properties,Usage,Production

Originator

Herperal,Farmitalia,Italy,1978

Manufacturing Process

A spore suspension obtained upon washing a culture of Streptomyces distallicus is added to 3,000 ml of a sterile medium consisting of the following:Dextrose 2% Corn steep liquor extract 2% CaCO3 1% (NH4)2SO4 0.3% NaCl 0.3%Fermentation is continued at 28°C for 40 hours at a stirring rate of 150 to 250 rpm and a rate of air flow of 1 to 2 l/min/l of culture medium.
300 ml of a suspension of the vegetative mycelium of this culture are used for inoculating 6,000 ml of a similar sterile culture medium. At this production stage, the culture is kept fermenting for 85 to 100 hours (pH 7.6 at 28°C) at a stirring rate of 350 to 450 rpm and a rate of air flow of 1 to 1.5 l/min/l of culture medium.
To 17 l of a culture obtained by submerged fermentation as mentioned above, siliceous earth is added and the batch is filtered. The mixture of mycelium and the siliceous earth are agitated for 1 hour with 2.5 l of butanol. This treatment is repeated twice. The butanolic extracts are combined, washed with water, evaporated to dryness (about 10 g) and boiled with acetone (80 ml). The 5 g of distamycin is extracted six times with ethanol. The ethanolic extracts are combined, concentrated and filtered through a column containing 70 g of alumina. Elution is carried out with the same solvent. The effluent (central fractions) is collected and evaporated to dryness to yield 0.43 g of pure distamycin A: decomposition point, 183°C to 185°C. The product can be further purified by crystallization from aqueous n-butanol.

Therapeutic Function

Antibiotic

DISTAMYCIN A HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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DISTAMYCIN A HYDROCHLORIDE Suppliers

China 7 China Hong Kong 1 Germany 3 Italy 1 Switzerland 1 United Kingdom 1 United States 6 Global 20

Chizhou Kailong Import and Export Trade Co., Ltd.

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Hangzhou Synstar pharmaceutical Technology CO.,Ltd

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Alfa Chemistry

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TopScience Biochemical

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Shaanxi Dideu Newmaterial Co., Ltd.

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Hubei Enxing Biotechnology Co., Ltd

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Henan Tianfu Chemical Co.,Ltd.

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Country: China
ProdList: 21691
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6576-51-8, DISTAMYCIN A HYDROCHLORIDERelated Search:

(1-METHYL-1H-PYRROL-2-YL)METHYLAMINE 1H-PYRROLE-2-CARBOXAMIDE Tallimustine Stallimycin 1H-Pyrrole-2-carboxamide, 4-(((4-((((aminoiminomethyl)amino)acetyl)ami no)-1-methyl-1H-pyrrol-2-yl)carbonyl)amino)-N-(5-(((2-(aminoiminomethy l)-1-methylethyl)amino)carbonyl)-1-methyl-1H-pyrrol-3-yl)-1-methyl-, d ihydrochloride DISTAMYCIN A HYDROCHLORIDE METHYL-(1-METHYL-1H-PYRROL-2-YLMETHYL)-AMINE 1H-Pyrrole-2-carboxamide, 4-(((4-((((aminoiminomethyl)amino)acetyl)ami no)-1-methyl-1H-pyrrol-2-yl)carbonyl)amino)-N-(5-(((3-amino-3-iminopro pyl)amino)carbonyl)-1-methyl-1H-pyrrol-3-yl)-1-methyl-, dihydrochlorid e N-Methylpyrrole-2-carboxaldehyde propionamidine hydrochloride

1H-Pyrrole-2-carboxaMide,N-[5-[[(3-aMino-3-iMinopropyl)aMino]carbonyl]-1-Methyl-1H-pyrrol-3-yl]-4-[[[4-(forMylaMino)-1-Methyl-1H-pyrrol-2-yl]carbonyl]aMino]-1-Methyl-,hydrochloride (1:1)

N-[5-[[(3-amino-3-iminopropyl)amino]carbonyl]-1-methyl-1H-pyrrol-3-yl]-4-[[[4-(formylamino)-1-me

distamycin A hydrochloride from*streptomyces dist

N-[5-[[(3-amino-3-iminopropyl)amino]carbonyl]-1-methyl-1H-pyrrol-3-yl]-4-[[[4-(formylamino)-1-methyl-1H-pyrrol-2-yl]carbonyl]amino]-1-methyl-1H-pyrrole-2-carboxamide monohydrochloride

Distamycin A hydrochloride from Streptomyces distallicus

MEN-10399

DISTAMYCIN A HYDROCHLORIDE FROM*STREPTOM YCES DISTAL

estalimicinaclorhidrato

fi6426

herperal

stallimycinhydrochloride

DISTAMYCIN A HCL

DISTAMYCIN A HYDROCHLORIDE

6576-51-8

C22H27N9O4HCl

C22H28O4N9Cl

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