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IDAZOXAN HYDROCHLORIDE

Product Name
IDAZOXAN HYDROCHLORIDE
CAS No.
79944-56-2
Chemical Name
IDAZOXAN HYDROCHLORIDE
Synonyms
RX 781094A;IdazoxanHCl;Idazoxan hydrochlori;IDAZOXAN HYDROCHLORIDE;(+/-)-Idazoxan Monohydrochloride;Idazoxan hydrochloride, 10 mM in DMSO;2-(1,4-BENZODIOXAN-2-YL)-2-IMIDAZOLINE HYDROCHLORIDE;Idazoxan hydrochloride, alpha2 Adrenoceptor antagonist and I2 ligand;RX 781094, (±)-2-[1,4-Benzodioxan-2-yl]-2-imidazoline hydrochloride;Idazoxan hydrochloride,2-(1,4-Benzodioxan-2-yl)-2-imidazolinehydrochloride
CBNumber
CB5236802
Molecular Formula
C11H13ClN2O2
Formula Weight
240.69
MOL File
79944-56-2.mol
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IDAZOXAN HYDROCHLORIDE Property

Melting point:
207-208°
storage temp. 
Store at RT
solubility 
H2O: 300 mg/mL
form 
Powder
color 
White to off-white
Water Solubility 
Soluble to 100 mM in water
Stability:
Hygroscopic
InChI
InChI=1S/C11H12N2O2.ClH/c1-2-4-9-8(3-1)14-7-10(15-9)11-12-5-6-13-11;/h1-4,10H,5-7H2,(H,12,13);1H
InChIKey
MYUBYOVCLMEAOH-UHFFFAOYSA-N
SMILES
C1(COC2C=CC=CC=2O1)C1=NCCN1.Cl
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Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
7
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
I6138
Product name
Idazoxan hydrochloride
Packaging
50mg
Price
$112.1
Updated
2025/07/31
Sigma-Aldrich
Product number
I6138
Product name
Idazoxan hydrochloride
Packaging
100mg
Price
$149.15
Updated
2025/07/31
Sigma-Aldrich
Product number
5.04746
Product name
IdazoxanHydrochloride-CAS79944-56-2-Calbiochem
Packaging
50mg
Price
$146
Updated
2022/05/15
Tocris
Product number
0793
Product name
Idazoxan hydrochloride
Purity
≥98%
Packaging
10
Price
$159
Updated
2021/12/16
Tocris
Product number
0793
Product name
Idazoxan hydrochloride
Purity
≥98%
Packaging
50
Price
$647
Updated
2021/12/16
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IDAZOXAN HYDROCHLORIDE Chemical Properties,Usage,Production

Chemical Properties

mp 207-209°C

Uses

Idazoxan hydrochloride has been used to study the efficacy of antidepressant treatments that interact with multiple neurotransmitter systems.

Uses

Antiparkinsonian;Alpha2 agonist

Uses

An α-adrenoceptor antagonist; in rat brain Idazoxan is a pure antagonist and it has a selectivity for α2- over α1-receptors markedly superior to Piperoxane, Yohimbine, or Rauwolscine. Antiparkinsonian.

Biological Activity

α 2 -adrenoceptor antagonist, and I 2 ligand, selective over I 1 sites (pK i values are 5.90, 7.22, 8.01, 7.43, and 7.7 for I 1 , I 2 , α 2A , α 2B , and α 2C receptors respectively).

Biochem/physiol Actions

α2-adrenoceptor antagonist; I2?imidazoline receptor agonist; I1?imidazoline receptor antagonist. Idazoxan can antagonize various behaviors generated by ethanol in a preclinical setting. It possesses neuroprotective activity against spinal cord injury, resulted due to experimental autoimmune encephalomyelitis (EAE) in mouse, an animal modal of multiple sclerosis (MS).

in vivo

Idazoxan (0.16-5 mg/kg; subcutaneous injection; for 1 hour; male CD-COBS rats) treatment potently reverses haloperidol-induced catalepsy with an ED50 of 0.25?mg/kg. Idazoxan (0.3 and 2.5?mg/kg) has no effect on extracellular DA and do not modify the rise of extracellular DA induced by haloperidol[1].

Animal Model:Male CD-COBS rats injected with 1?mg/kg haloperidol[1]
Dosage:0.16 mg/kg, 0.31 mg/kg, 0.63 mg/kg, 1.25 mg/kg, 2.5 mg/kg, and 5.0?mg/kg
Administration:Subcutaneous injection; for 1 hour
Result:Potently reversed haloperidol-induced catalepsy with an ED50 of 0.25?mg/kg.

IC 50

α adrenergic receptor

IDAZOXAN HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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IDAZOXAN HYDROCHLORIDE Suppliers

Canada 1 China 56 Germany 2 India 1 Switzerland 1 United Kingdom 5 United States 17 USA 1 Global 84
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79944-56-2, IDAZOXAN HYDROCHLORIDERelated Search:

2-PHENOXYPROPYLAMINE HYDROCHLORIDE 2-METHOXYACETAMIDINE HYDROCHLORIDE 2,3-DIHYDRO-1,4-BENZODIOXIN-2-YLMETHYLAMINE 2-Isopropoxyphenol propionamidine hydrochloride 2-(2-Methoxyphenoxy)ethylamine 2-PHENOXYACETAMIDINE HYDROCHLORIDE 1,4-Benzodioxan 2-(2-METHOXYPHENOXY)-N-METHYLETHYLAMINE 3-AMINO-1-PHENOXY-2-PROPANOL HYDROCHLORIDE, 98 Idazoxan AKOS BBS-00007965 CHEMBRDG-BB 9070636 1,4-BENZODIOXAN-2-METHYLAMINE, N-METHYL- 2-HYDROXY-PROPIONAMIDINE CHEMBRDG-BB 5482082 1-AMINO-3-PHENOXY-PROPAN-2-OL 2-HYDROXY-ACETAMIDINE HCL

  • (+/-)-Idazoxan Monohydrochloride
  • 2-(2,3-Dihydro-1,4-benzodioxin-2-yl)-4,5-dihydro-1H-iMidazole Hydrochloride
  • RX 781094A
  • 2-(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)-4,5-dihydro-1H-iMidazole hydrochloride
  • IDAZOXAN HYDROCHLORIDE
  • 2-(1,4-BENZODIOXAN-2-YL)-2-IMIDAZOLINE HYDROCHLORIDE
  • IdazoxanHCl
  • RX 781094, (±)-2-[1,4-Benzodioxan-2-yl]-2-imidazoline hydrochloride
  • Idazoxan hydrochloride,2-(1,4-Benzodioxan-2-yl)-2-imidazolinehydrochloride
  • Idazoxan hydrochlori
  • RX781094,inhibit,Adrenergic Receptor,RX-781094,Idazoxan,Inhibitor,Beta Receptor,Idazoxan hydrochloride,Imidazoline Receptor
  • Idazoxan hydrochloride, alpha2 Adrenoceptor antagonist and I2 ligand
  • Idazoxan hydrochloride, 10 mM in DMSO
  • 79944-56-2
  • 79944-65-2
  • Adrenoceptor
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals