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Florantyrone

Product Name
Florantyrone
CAS No.
519-95-9
Chemical Name
Florantyrone
Synonyms
Zanchol;florantyrone;γ-Oxo-8-fluoranthenebutyric acid;b-(8-Fluoranthoyl)propionic acid;g-Oxo-8-fluoranthenebutanoic acid;3-(4-PHENYLBENZOYL)PROPIONIC ACID;4-(4-BIPHENYLYL)-4-OXOBUTYRIC ACID;b-(8-Fluoranthyloyl)propionic acid;8-Fluoranthenebutanoic acid, γ-oxo-;g-Fluoranthen-8-yl-g-oxybutyric acid
CBNumber
CB5239126
Molecular Formula
C20H14O3
Formula Weight
302.32
MOL File
519-95-9.mol
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Florantyrone Property

Melting point:
184-187 °C(lit.)
Boiling point:
574.2±33.0 °C(Predicted)
Density 
1.367±0.06 g/cm3(Predicted)
CAS DataBase Reference
519-95-9(CAS DataBase Reference)
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
28-45
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
DV1761000
Hazardous Substances Data
519-95-9(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0011456
Product name
FLORANTYRONE
Purity
95.00%
Packaging
5MG
Price
$502.29
Updated
2021/12/16
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Florantyrone Chemical Properties,Usage,Production

Originator

Zanchol,Searle,US,1957

Definition

ChEBI: Florantyrone is a butanone.

Manufacturing Process

50 g of fluoranthene and 26 g of succinic anhydride in 500 cc of nitrobenzene were treated at 0°C to 5°C with 75 g of anhydrous aluminum chloride. The temperature was held at 0°C for 4 hours and then allowed gradually to come to room temperature. The reaction mixture was allowed to stand for 16 hours. The reaction mixture was then worked up. In so doing, the reaction mixture was decomposed with dilute HCl, the nitrobenzene was removed by steam distillation and the residue after filtration was dissolved in hot sodium carbonate solution and filtered free of a small amount of nonacidic material. Precipitation from solution with HCl gave a light yellow product which crystallized from a 50-50 mixture of dioxane alcohol as fine platelets which melted at 192°C to 194°C and showed a neutral equivalent of 308 which corresponds closely to the theoretical value of 302 for β-fluoranthoylpropionic acid.
25 g of the crude acid was dissolved in 100 cc of water containing 13 g of sodium carbonate. On cooling a thick syrup was obtained. On dilution to 1 liter precipitation started and after standing 16 hours, the solid which separated was filtered (filtrate treated as below), suspended in water, acidified with HCl and filtered. Crystallization from alcohol gave a light yellow material melting at 199°C to 200°C and having a neutral equivalent of 303.
The filtrate mentioned above, upon acidification thereof with HCl gave a darker acid which melted over a wide range, but had a neutral equivalent which also corresponds to that of β-fluoranthoylpropionic acid.

Therapeutic Function

Hydrocholeretic

Florantyrone Preparation Products And Raw materials

Raw materials

Preparation Products

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Florantyrone Suppliers

Hubei Jusheng Technology Co.,Ltd.
Tel
18871490254
Fax
027-59599243
Email
linda@hubeijusheng.com
Country
CHINA
ProdList
28180
Advantage
58
Shaanxi Dideu Medichem Co. Ltd
Tel
+86-29-87569266 15319487004
Fax
029-88380327
Email
1015@dideu.com
Country
China
ProdList
4088
Advantage
58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
13675144456
Fax
025-85563444
Email
sean.lv@synzest.com
Country
China
ProdList
10787
Advantage
58
Shaanxi Dideu Medichem Co. Ltd
Tel
029-61856358 15229202216
Fax
029-88380327
Email
1020@dideu.com
Country
China
ProdList
10011
Advantage
58

519-95-9, FlorantyroneRelated Search:


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