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Fenbufen

Product Name
Fenbufen
CAS No.
36330-85-5
Chemical Name
Fenbufen
Synonyms
bufemid;cl82204;napanol;cinopal;Cinopol;enbufen;lederfen;FENBUFEN;Fenbufen CRS;FENBUFENTABLETS
CBNumber
CB2239125
Molecular Formula
C16H14O3
Formula Weight
254.29
MOL File
36330-85-5.mol
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Fenbufen Property

Melting point:
184-187 °C (lit.)
Boiling point:
357.5°C (rough estimate)
Density 
1.1565 (rough estimate)
refractive index 
1.5600 (estimate)
storage temp. 
2-8°C
solubility 
Very slightly soluble in water, slightly soluble in acetone, in ethanol (96 per cent) and in methylene chloride.
pka
pKa 4.3(H2O tunde?ned Iunde?ned) (Uncertain)
form 
Solid
color 
White to off-white
Water Solubility 
2.212mg/L(25 ºC)
Merck 
13,3990
EPA Substance Registry System
[1,1'-Biphenyl]-4-butanoic acid, .gamma.-oxo- (36330-85-5)
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
28-45
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
DV1761000
HazardClass 
6.1
PackingGroup 
III
HS Code 
2918300090
Toxicity
LD50 in various strains of mice, rats (mg/kg): 795-1673, 200-720 orally; 506-811, 265-575 i.p. (Bolte)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
BP354
Product name
Fenbufen
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
100MG
Price
$257
Updated
2024/03/01
Sigma-Aldrich
Product number
F8755
Product name
Fenbufen
Purity
analytical standard
Packaging
5g
Price
$110
Updated
2022/05/15
Alfa Aesar
Product number
H60557
Product name
4-(4-Biphenylyl)-4-oxobutyric acid, 96%
Packaging
1g
Price
$45.65
Updated
2024/03/01
Alfa Aesar
Product number
H60557
Product name
4-(4-Biphenylyl)-4-oxobutyric acid, 96%
Packaging
5g
Price
$151.65
Updated
2024/03/01
Cayman Chemical
Product number
28851
Product name
Fenbufen
Packaging
5g
Price
$93
Updated
2024/03/01
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Fenbufen Chemical Properties,Usage,Production

Description

Fenbufen has been found to be an effective, well-tolerated drug for the treatment of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. Fenbufen is prepared by the Friedel-Crafts (aluminum chloride – nitrobenzene) acylation of biphenyl with succinic anhydride. The compound is metabolized in humans first to 4-hydroxy-4-biphenylbutyric acid (tmax 2.5 h) then to 4-biphenyl acetic acid (tmax 7.5 h). Both metabolites are more active than fenbufen itself and circulate for several hours (t1/2 10 h). This slow conversion of fenbufen to active metabolites having relatively long plasma half-lives allows for once a day dosing with this agent.

Chemical Properties

White Solid

Originator

Cinopal,Cyanamid,Italy,1976

Uses

Cyclo-oxygenase inhibitor; analgesic; anti-inflammatory

Uses

muscle relaxant (smooth)

Definition

ChEBI: Fenbufen is a member of biphenyls and a 4-oxo monocarboxylic acid. It has a role as a non-steroidal anti-inflammatory drug.

Manufacturing Process

135 g of aluminum chloride is dissolved in 500 ml of nitrobenzene, the solution being held below 10°C by external cooling. A finely ground mixture of 50 g of succinic anhydride and 75 g of biphenyl is added to the stirred solution, the temperature being held below 10°C. It is then held at room temperature for four days. After pouring the reaction mixture into a solution of 150 ml of concentrated hydrochloric acid in 1 liter of ice water, the nitrobenzene is removed by steam distillation. The solid is collected, dissolved in 4 liters of 3% hot sodium carbonate solution, clarified, and reprecipitated by the addition of excess 6N sulfuric acid solution. The crude product is collected, dried, and recrystallized from ethanol to give the pure subject compound, MP 185°C to 187°C.

Therapeutic Function

Antiinflammatory

General Description

Fenbufen belongs to the class of non-steroidal anti-inflammatory drugs, widely used as an antipyretic and analgesic in medical applications. Its mode of action involves the inhibition of cyclooxygenase enzyme and thereby prevents the synthesis of certain prostaglandins.

Trade name

Clincopal (Lederle, Spain), Lederfen (Lederle, UK), Napanol (Lederle, Japan).

Safety Profile

Poison by ingestion,intraperitoneal, and subcutaneous routes. Human systemiceffects by ingestion: cough, sweating, body temperature.An experimental teratogen. Other experimentalreproductive effects. An anti-inflammatory agent. Whenheated to decomposi

Fenbufen Preparation Products And Raw materials

Raw materials

Preparation Products

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Fenbufen Suppliers

Jinan Wald Chemical Co., Ltd.
Tel
0531-88773586 13210588999
Fax
053188773586
Email
304264064@qq.com
Country
China
ProdList
193
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30132
Advantage
84
ShangHai DEMO Chemical Co.,Ltd
Tel
400-021-7337 2355568890
Fax
0086-21-50182339
Email
sales@demochem.com
Country
China
ProdList
2572
Advantage
57
Beijing HwrkChemical Technology Co., Ltd
Tel
010-89508211 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
8415
Advantage
55
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44700
Advantage
61
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14104
Advantage
59
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32344
Advantage
50
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768850
Email
1791901229@qq.com
Country
China
ProdList
8846
Advantage
52
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12990
Advantage
57
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View Lastest Price from Fenbufen manufacturers

Hebei Chuanghai Biotechnology Co,.LTD
Product
4-(4-Biphenyl)-4-oxobutyric acid 36330-85-5
Price
US $1.90/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 ton
Release date
2024-08-20
Liaoning Pharmaceutical Innovation Co., Ltd
Product
Fenbufen 36330-85-5
Price
US $100.00-1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 tons
Release date
2024-03-06
Xiamen Wonderful Bio Technology Co., Ltd.
Product
fenbufen 36330-85-5
Price
US $66.00/KG
Min. Order
1250KG
Purity
99%
Supply Ability
330T
Release date
2023-07-21

36330-85-5, FenbufenRelated Search:


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  • GAMMA-OXO(1,1'-BIPHENYL)-BUTANOIC ACID
  • 4-(4-BIPHENYL)-4-OXOBUTYRIC ACID
  • 4-(4-BIPHENYLYL)-4-OXOBUTYRIC ACID
  • 3-(4-PHENYLBENZOYL)PROPIONIC ACID
  • cl82204
  • diphenyl-4-gamma-oxo-gamma-butyricacid
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