Fenbufen
- Product Name
- Fenbufen
- CAS No.
- 36330-85-5
- Chemical Name
- Fenbufen
- Synonyms
- bufemid;cl82204;napanol;cinopal;Cinopol;enbufen;lederfen;FENBUFEN;Fenbufen CRS;FENBUFENTABLETS
- CBNumber
- CB2239125
- Molecular Formula
- C16H14O3
- Formula Weight
- 254.29
- MOL File
- 36330-85-5.mol
Fenbufen Property
- Melting point:
- 184-187 °C (lit.)
- Boiling point:
- 357.5°C (rough estimate)
- Density
- 1.1565 (rough estimate)
- refractive index
- 1.5600 (estimate)
- storage temp.
- 2-8°C
- solubility
- Very slightly soluble in water, slightly soluble in acetone, in ethanol (96 per cent) and in methylene chloride.
- pka
- pKa 4.3(H2O tunde?ned Iunde?ned) (Uncertain)
- Water Solubility
- 2.212mg/L(25 ºC)
- Merck
- 13,3990
- EPA Substance Registry System
- [1,1'-Biphenyl]-4-butanoic acid, .gamma.-oxo- (36330-85-5)
N-Bromosuccinimide Price
- Product number
- BP354
- Product name
- Fenbufen
- Purity
- British Pharmacopoeia (BP) Reference Standard
- Packaging
- 100MG
- Price
- $257
- Updated
- 2024/03/01
- Product number
- F8755
- Product name
- Fenbufen
- Purity
- analytical standard
- Packaging
- 5g
- Price
- $110
- Updated
- 2022/05/15
- Product number
- H60557
- Product name
- 4-(4-Biphenylyl)-4-oxobutyric acid, 96%
- Packaging
- 1g
- Price
- $45.65
- Updated
- 2024/03/01
- Product number
- H60557
- Product name
- 4-(4-Biphenylyl)-4-oxobutyric acid, 96%
- Packaging
- 5g
- Price
- $151.65
- Updated
- 2024/03/01
- Product number
- 28851
- Product name
- Fenbufen
- Packaging
- 5g
- Price
- $93
- Updated
- 2024/03/01
Fenbufen Chemical Properties,Usage,Production
Description
Fenbufen has been found to be an effective, well-tolerated drug for the treatment of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. Fenbufen is prepared by the Friedel-Crafts (aluminum chloride – nitrobenzene) acylation of biphenyl with succinic anhydride. The compound is metabolized in humans first to 4-hydroxy-4-biphenylbutyric acid (tmax 2.5 h) then to 4-biphenyl acetic acid (tmax 7.5 h). Both metabolites are more active than fenbufen itself and circulate for several hours (t1/2 10 h). This slow conversion of fenbufen to active metabolites having relatively long plasma half-lives allows for once a day dosing with this agent.
Chemical Properties
White Solid
Originator
Cinopal,Cyanamid,Italy,1976
Uses
Cyclo-oxygenase inhibitor; analgesic; anti-inflammatory
Uses
muscle relaxant (smooth)
Definition
ChEBI: Fenbufen is a member of biphenyls and a 4-oxo monocarboxylic acid. It has a role as a non-steroidal anti-inflammatory drug.
Manufacturing Process
135 g of aluminum chloride is dissolved in 500 ml of nitrobenzene, the solution being held below 10°C by external cooling. A finely ground mixture of 50 g of succinic anhydride and 75 g of biphenyl is added to the stirred solution, the temperature being held below 10°C. It is then held at room temperature for four days. After pouring the reaction mixture into a solution of 150 ml of concentrated hydrochloric acid in 1 liter of ice water, the nitrobenzene is removed by steam distillation. The solid is collected, dissolved in 4 liters of 3% hot sodium carbonate solution, clarified, and reprecipitated by the addition of excess 6N sulfuric acid solution. The crude product is collected, dried, and recrystallized from ethanol to give the pure subject compound, MP 185°C to 187°C.
Therapeutic Function
Antiinflammatory
General Description
Fenbufen belongs to the class of non-steroidal anti-inflammatory drugs, widely used as an antipyretic and analgesic in medical applications. Its mode of action involves the inhibition of cyclooxygenase enzyme and thereby prevents the synthesis of certain prostaglandins.
Trade name
Clincopal (Lederle, Spain), Lederfen (Lederle, UK), Napanol (Lederle, Japan).
Safety Profile
Poison by ingestion,intraperitoneal, and subcutaneous routes. Human systemiceffects by ingestion: cough, sweating, body temperature.An experimental teratogen. Other experimentalreproductive effects. An anti-inflammatory agent. Whenheated to decomposi
Fenbufen Preparation Products And Raw materials
Raw materials
Preparation Products
View Lastest Price from Fenbufen manufacturers
- Product
- Fenbufen 36330-85-5
- Price
- US $100.00-1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2024-03-06
- Product
- Fenbufen 36330-85-5
- Price
- US $45.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000 tons
- Release date
- 2023-02-21
- Product
- Fenbufen 36330-85-5
- Price
- US $1.00-1.00/KG
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 50tons
- Release date
- 2020-04-29