AEG 3482

Product Name: AEG 3482
CAS No.: 63735-71-7
Chemical Name: AEG 3482
Synonyms: AEG 3482;AEG-3482/AEG3482;AEG 3482 >=98% (HPLC);6-PHENYLIMIDAZO[2,1-B]-1,3,4-THIADIAZOLE-2-SULFONAMIDE;IMIDAZO[2,1-B]-1,3,4-THIADIAZOLE-2-SULFONAMIDE, 6-PHENYL-;6-PHENYL-IMIDAZO[2,1-B][1,3,4]THIADIAZOLE-2-SULFONIC ACID AMIDE
CBNumber: CB52446843
Molecular Formula: C10H8N4O2S2
Formula Weight: 280.33
MOL File: 63735-71-7.mol

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AEG 3482 Property

Density: 1.75
storage temp.: Store at RT
solubility: DMSO: ≥15mg/mL
form: powder
pka: 5.05±0.60(Predicted)
color: faint yellow to dark yellow

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0264
Product name: AEG 3482
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $130
Updated: 2024/03/01

Cayman Chemical

Product number: 26213
Product name: AEG 3482
Packaging: 5mg
Price: $100
Updated: 2024/03/01

Cayman Chemical

Product number: 26213
Product name: AEG 3482
Packaging: 25mg
Price: $381
Updated: 2024/03/01

Cayman Chemical

Product number: 26213
Product name: AEG 3482
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 26213
Product name: AEG 3482
Packaging: 10mg
Price: $169
Updated: 2024/03/01

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AEG 3482 Chemical Properties,Usage,Production

Uses

AEG 3482 is an antiapoptotic compound that inhibits Jun Kinase Activity (JNK) and cell death through induced expression of heat shock protein 70. AEG 3482 shows possible use in the treatment of neurological disorders.

Definition

ChEBI: 6-phenyl-2-imidazo[2,1-b][1,3,4]thiadiazolesulfonamide is a member of imidazoles.

Biological Activity

Inhibitor of c-jun N-terminal kinase (JNK) signaling. Binds Hsp90 and facilitates HSF1 release, induces expression of Hsp70, which in turn blocks JNK activation and JNK-dependent apoptosis. Antiapoptotic; inhibits NGF withdrawal-induced death in SCG neurons (EC 50 = 20 μ M).

References

[1]salehi ah, morris sj, ho wc, etal. , aeg3482 is an antiapoptotic compound that inhibits jun kinase activity and cell death through induced expression of heat shock protein 70. chem biol. 2006 feb;13(2):213-23.
[2] gallo ka. targeting hsp90 to halt neurodegeneration. chem biol. 2006 feb;13(2):115-6.

AEG 3482 Preparation Products And Raw materials

Raw materials

Preparation Products

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AEG 3482 Suppliers

China 40 The Netherlands 1 United Kingdom 2 United States 9 USA 1 Global 53

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
Advantage: 60

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 7295
Advantage: 58

Amatek Scientific Co. Ltd.

Tel: 0512-56316828
Fax: 0512-56316826
Email: info@amateksci.com
Country: China
ProdList: 28806
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

ShangHai ChuanQian Chemcial Technique Centre

Tel: 15869524721
Email: 3525679403@qq.com
Country: China
ProdList: 4010
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

63735-71-7, AEG 3482Related Search:

Imidazo(2,1-b)-1,3,4-thiadiazole-2-sulfonamide, 6-(1,1'-biphenyl)-4-yl)- AEG 3482

6-PHENYL-IMIDAZO[2,1-B][1,3,4]THIADIAZOLE-2-SULFONIC ACID AMIDE

6-PHENYLIMIDAZO[2,1-B]-1,3,4-THIADIAZOLE-2-SULFONAMIDE

AEG 3482

IMIDAZO[2,1-B]-1,3,4-THIADIAZOLE-2-SULFONAMIDE, 6-PHENYL-

AEG 3482 >=98% (HPLC)

AEG-3482/AEG3482

63735-71-7