ChemicalBook > CAS DataBase List > AEG 3482

AEG 3482

Product Name
AEG 3482
CAS No.
63735-71-7
Chemical Name
AEG 3482
Synonyms
AEG 3482;AEG-3482/AEG3482;AEG 3482 >=98% (HPLC);6-PHENYLIMIDAZO[2,1-B]-1,3,4-THIADIAZOLE-2-SULFONAMIDE;IMIDAZO[2,1-B]-1,3,4-THIADIAZOLE-2-SULFONAMIDE, 6-PHENYL-;6-PHENYL-IMIDAZO[2,1-B][1,3,4]THIADIAZOLE-2-SULFONIC ACID AMIDE
CBNumber
CB52446843
Molecular Formula
C10H8N4O2S2
Formula Weight
280.33
MOL File
63735-71-7.mol
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AEG 3482 Property

Density 
1.75
storage temp. 
Store at RT
solubility 
DMSO: ≥15mg/mL
form 
powder
pka
5.05±0.60(Predicted)
color 
faint yellow to dark yellow
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Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0264
Product name
AEG 3482
Purity
≥98% (HPLC)
Packaging
5mg
Price
$130
Updated
2024/03/01
Cayman Chemical
Product number
26213
Product name
AEG 3482
Packaging
5mg
Price
$100
Updated
2024/03/01
Cayman Chemical
Product number
26213
Product name
AEG 3482
Packaging
25mg
Price
$381
Updated
2024/03/01
Cayman Chemical
Product number
26213
Product name
AEG 3482
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
26213
Product name
AEG 3482
Packaging
10mg
Price
$169
Updated
2024/03/01
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AEG 3482 Chemical Properties,Usage,Production

Uses

AEG 3482 is an antiapoptotic compound that inhibits Jun Kinase Activity (JNK) and cell death through induced expression of heat shock protein 70. AEG 3482 shows possible use in the treatment of neurological disorders.

Definition

ChEBI: 6-phenyl-2-imidazo[2,1-b][1,3,4]thiadiazolesulfonamide is a member of imidazoles.

Biological Activity

Inhibitor of c-jun N-terminal kinase (JNK) signaling. Binds Hsp90 and facilitates HSF1 release, induces expression of Hsp70, which in turn blocks JNK activation and JNK-dependent apoptosis. Antiapoptotic; inhibits NGF withdrawal-induced death in SCG neurons (EC 50 = 20 μ M).

References

[1]salehi ah, morris sj, ho wc, etal. , aeg3482 is an antiapoptotic compound that inhibits jun kinase activity and cell death through induced expression of heat shock protein 70. chem biol. 2006 feb;13(2):213-23.
[2] gallo ka. targeting hsp90 to halt neurodegeneration. chem biol. 2006 feb;13(2):115-6.

AEG 3482 Preparation Products And Raw materials

Raw materials

Preparation Products

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AEG 3482 Suppliers

China 40 The Netherlands 1 United Kingdom 2 United States 9 USA 1 Global 53
3B Pharmachem (Wuhan) International Co.,Ltd.
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63735-71-7, AEG 3482Related Search:

Imidazo(2,1-b)-1,3,4-thiadiazole-2-sulfonamide, 6-(1,1'-biphenyl)-4-yl)- AEG 3482

  • 6-PHENYL-IMIDAZO[2,1-B][1,3,4]THIADIAZOLE-2-SULFONIC ACID AMIDE
  • 6-PHENYLIMIDAZO[2,1-B]-1,3,4-THIADIAZOLE-2-SULFONAMIDE
  • AEG 3482
  • IMIDAZO[2,1-B]-1,3,4-THIADIAZOLE-2-SULFONAMIDE, 6-PHENYL-
  • AEG 3482 >=98% (HPLC)
  • AEG-3482/AEG3482
  • 63735-71-7