6-BROMO-PYRAZOLO[1,5-A]PYRIMIDINE

Product Name: 6-BROMO-PYRAZOLO[1,5-A]PYRIMIDINE
CAS No.: 705263-10-1
Chemical Name: 6-BROMO-PYRAZOLO[1,5-A]PYRIMIDINE
Synonyms: 6-broMopyrazolo[1;6-Bromopyrazolo[1,5-a]pyr...;6-BROMO-PYRAZOLO[1,5-A]PYRIMIDINE;Pyrazolo[1,5-a]pyriMidine, 6-broMo-;6-BROMO-PYRAZOLO[1,5-A]PYRIMIDINE ISO 9001：2015 REACH
CBNumber: CB52451003
Molecular Formula: C6H4BrN3
Formula Weight: 198.02
MOL File: 705263-10-1.mol

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6-BROMO-PYRAZOLO[1,5-A]PYRIMIDINE Property

Melting point:: 122-124℃
Density: 1.89±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: solid
pka: -0.81±0.30(Predicted)
color: Light yellow
Water Solubility: Slightly soluble in water.
Sensitive: Light Sensitive
InChI: InChI=1S/C6H4BrN3/c7-5-3-8-6-1-2-9-10(6)4-5/h1-4H
InChIKey: VDHTXLUCUNPVLO-UHFFFAOYSA-N
SMILES: C12=CC=NN1C=C(Br)C=N2

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Safety

HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B6505
Product name: 6-Bromopyrazolo[1,5-a]pyrimidine
Packaging: 1G
Price: $57
Updated: 2025/07/31

TCI Chemical

Product number: B6505
Product name: 6-Bromopyrazolo[1,5-a]pyrimidine
Packaging: 5G
Price: $171
Updated: 2025/07/31

TRC

Product number: B687660
Product name: 6-Bromopyrazolo[1,5-a]pyrimidine
Packaging: 10g
Price: $525
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: B13934
Product name: 6-Bromopyrazolo[1,5-a]pyrimidine
Packaging: 1g
Price: $25
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB140359
Product name: 6-Bromo-pyrazolo[1,5-a]pyrimidine
Packaging: 1g
Price: $50
Updated: 2021/12/16

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6-BROMO-PYRAZOLO[1,5-A]PYRIMIDINE Chemical Properties,Usage,Production

Uses

6-Bromopyrazolo[1,5-a]pyrimidine is a reactant in the synthesis of LDN-212854, a selective and potent inhibitor of the BMP type I receptor kinases.

Synthesis

2065-75-0

1225387-53-0

705263-10-1

Using 2-bromomalonaldehyde (15.1 g, 100 mmol) and 3H-pyrazol-3-amine (8.3 g, 100 mmol) as raw materials, 120 mL of ethanol was added to a 250 mL round bottom flask and the mixture was cooled down to 0 °C. Subsequently, 12 mL of concentrated hydrochloric acid was slowly added and after returning to room temperature, stirring was continued for 2 hours. During the reaction, a yellowish solid precipitated. Upon completion of the reaction, the solid was collected by direct filtration and the filter cake was washed sequentially with saturated NaHCO3 solution and distilled water. After drying, 17 g of the intermediate 6-bromopyrazolo[1,5-a]pyrimidine was obtained in 86% yield.

References

[1] Patent: CN105130991, 2017, B. Location in patent: Paragraph 0037; 0041-0043
[2] Patent: WO2014/138088, 2014, A1. Location in patent: Page/Page column 60
[3] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 15, p. 4388 - 4392
[4] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 23, p. 5830 - 5835

6-BROMO-PYRAZOLO[1,5-A]PYRIMIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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6-BROMO-PYRAZOLO[1,5-A]PYRIMIDINE Suppliers

China 146 India 2 United Kingdom 2 United States 19 Global 169

wuhan Dekray Biomedical Technology Co.,Ltd

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Shanghai Shinso-pharm Technology Co., Ltd.

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J & K SCIENTIFIC LTD.

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Alfa Aesar

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Energy Chemical

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Capot Chemical Co., Ltd

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Shangchem Co., Ltd.

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Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
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Country: United States
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View Lastest Price from 6-BROMO-PYRAZOLO[1,5-A]PYRIMIDINE manufacturers

Dideu Industries Group Limited

Product: 6-BROMO-PYRAZOLO[1,5-A]PYRIMIDINE 705263-10-1
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-12-01

Career Henan Chemical Co

Product: 6-BROMO-PYRAZOLO[1,5-A]PYRIMIDINE 705263-10-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2018-12-25

705263-10-1, 6-BROMO-PYRAZOLO[1,5-A]PYRIMIDINERelated Search:

6-BROMO-PYRAZOLO[1,5-A]PYRIMIDINE-2-CARBOXYLIC ACID 6-BroMopyrazolo[1,5-a]pyridine ETHYL 6-BROMOPYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXYLATE 6-BROMO-PYRAZOLO[1,5-A]PYRIMIDINE 6-bromo-2-methylpyrazolo[1,5-a]pyrimidine-3-carbaldehyde 6-BROMO-PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBONITRILE 6-Bromo-2-methylpyrazolo[1,5-a]pyrimidine AKOS B020191 6-bromo-3-chloropyrazolo[1,5-a]pyrimidine-2-carboxylic acid

6-BROMO-PYRAZOLO[1,5-A]PYRIMIDINE

6-Bromopyrazolo[1,5-a]pyr...

6-broMopyrazolo[1

Pyrazolo[1,5-a]pyriMidine, 6-broMo-

6-BROMO-PYRAZOLO[1,5-A]PYRIMIDINE ISO 9001：2015 REACH

705263-10-1

Heterocycle-Pyrimidine series