ChemicalBook > CAS DataBase List > 6-BROMO-PYRAZOLO[1,5-A]PYRIMIDINE

6-BROMO-PYRAZOLO[1,5-A]PYRIMIDINE

Product Name
6-BROMO-PYRAZOLO[1,5-A]PYRIMIDINE
CAS No.
705263-10-1
Chemical Name
6-BROMO-PYRAZOLO[1,5-A]PYRIMIDINE
Synonyms
6-broMopyrazolo[1;6-Bromopyrazolo[1,5-a]pyr...;6-BROMO-PYRAZOLO[1,5-A]PYRIMIDINE;Pyrazolo[1,5-a]pyriMidine, 6-broMo-;6-BROMO-PYRAZOLO[1,5-A]PYRIMIDINE ISO 9001：2015 REACH
CBNumber
CB52451003
Molecular Formula
C6H4BrN3
Formula Weight
198.02
MOL File
705263-10-1.mol
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6-BROMO-PYRAZOLO[1,5-A]PYRIMIDINE Property

Melting point:
122-124℃
Density 
1.89±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
form 
solid
pka
-0.81±0.30(Predicted)
color 
Light yellow
Water Solubility 
Slightly soluble in water.
Sensitive 
Light Sensitive
InChI
InChI=1S/C6H4BrN3/c7-5-3-8-6-1-2-9-10(6)4-5/h1-4H
InChIKey
VDHTXLUCUNPVLO-UHFFFAOYSA-N
SMILES
C12=CC=NN1C=C(Br)C=N2
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Safety

HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
B6505
Product name
6-Bromopyrazolo[1,5-a]pyrimidine
Packaging
1G
Price
$57
Updated
2025/07/31
TCI Chemical
Product number
B6505
Product name
6-Bromopyrazolo[1,5-a]pyrimidine
Packaging
5G
Price
$171
Updated
2025/07/31
TRC
Product number
B687660
Product name
6-Bromopyrazolo[1,5-a]pyrimidine
Packaging
10g
Price
$525
Updated
2021/12/16
SynQuest Laboratories
Product number
3H32-9-96
Product name
6-Bromopyrazolo[1,5-a]pyrimidine
Packaging
25g
Price
$850
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0143422
Product name
6-BROMOPYRAZOLO[1,5-A]PYRIMIDINE
Purity
95.00%
Packaging
250MG
Price
$889.35
Updated
2021/12/16
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6-BROMO-PYRAZOLO[1,5-A]PYRIMIDINE Chemical Properties,Usage,Production

Uses

6-Bromopyrazolo[1,5-a]pyrimidine is a reactant in the synthesis of LDN-212854, a selective and potent inhibitor of the BMP type I receptor kinases.

Synthesis

2065-75-0

1225387-53-0

705263-10-1

Using 2-bromomalonaldehyde (15.1 g, 100 mmol) and 3H-pyrazol-3-amine (8.3 g, 100 mmol) as raw materials, 120 mL of ethanol was added to a 250 mL round bottom flask and the mixture was cooled down to 0 °C. Subsequently, 12 mL of concentrated hydrochloric acid was slowly added and after returning to room temperature, stirring was continued for 2 hours. During the reaction, a yellowish solid precipitated. Upon completion of the reaction, the solid was collected by direct filtration and the filter cake was washed sequentially with saturated NaHCO3 solution and distilled water. After drying, 17 g of the intermediate 6-bromopyrazolo[1,5-a]pyrimidine was obtained in 86% yield.

References

[1] Patent: CN105130991, 2017, B. Location in patent: Paragraph 0037; 0041-0043
[2] Patent: WO2014/138088, 2014, A1. Location in patent: Page/Page column 60
[3] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 15, p. 4388 - 4392
[4] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 23, p. 5830 - 5835

6-BROMO-PYRAZOLO[1,5-A]PYRIMIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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6-BROMO-PYRAZOLO[1,5-A]PYRIMIDINE Suppliers

China 146 India 2 United Kingdom 2 United States 19 Global 169
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View Lastest Price from 6-BROMO-PYRAZOLO[1,5-A]PYRIMIDINE manufacturers

Dideu Industries Group Limited
Product
6-BROMO-PYRAZOLO[1,5-A]PYRIMIDINE 705263-10-1
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-12-01
Career Henan Chemical Co
Product
6-BROMO-PYRAZOLO[1,5-A]PYRIMIDINE 705263-10-1
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2018-12-25

705263-10-1, 6-BROMO-PYRAZOLO[1,5-A]PYRIMIDINERelated Search:

6-BROMO-PYRAZOLO[1,5-A]PYRIMIDINE-2-CARBOXYLIC ACID 6-BroMopyrazolo[1,5-a]pyridine ETHYL 6-BROMOPYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXYLATE 6-BROMO-PYRAZOLO[1,5-A]PYRIMIDINE 6-bromo-2-methylpyrazolo[1,5-a]pyrimidine-3-carbaldehyde 6-BROMO-PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBONITRILE 6-Bromo-2-methylpyrazolo[1,5-a]pyrimidine AKOS B020191 6-bromo-3-chloropyrazolo[1,5-a]pyrimidine-2-carboxylic acid

  • 6-BROMO-PYRAZOLO[1,5-A]PYRIMIDINE
  • 6-Bromopyrazolo[1,5-a]pyr...
  • 6-broMopyrazolo[1
  • Pyrazolo[1,5-a]pyriMidine, 6-broMo-
  • 6-BROMO-PYRAZOLO[1,5-A]PYRIMIDINE ISO 9001：2015 REACH
  • 705263-10-1
  • Heterocycle-Pyrimidine series