SULAMSEROD
- Product Name
- SULAMSEROD
- CAS No.
- 219757-90-1
- Chemical Name
- SULAMSEROD
- Synonyms
- RS-100302;SULAMSEROD;Methanesulfonamide, N-[2-[4-[3-(8-amino-7-chloro-2,3-dihydro-1,4-benzodioxin-5-yl)-3-oxopropyl]-1-piperidinyl]ethyl]-
- CBNumber
- CB52451311
- Molecular Formula
- C19H28ClN3O5S
- Formula Weight
- 445.96
- MOL File
- 219757-90-1.mol
SULAMSEROD Property
- Boiling point:
- 647.8±65.0 °C(Predicted)
- Density
- 1.319±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 11.22±0.40(Predicted)
N-Bromosuccinimide Price
- Product number
- API0019424
- Product name
- SULAMSEROD
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.85
- Updated
- 2021/12/16
SULAMSEROD Chemical Properties,Usage,Production
Uses
Sulamserod is a 5-HT4 receptor antagonist, with antiarrhythmic activities.
in vivo
Sulamserod (30 mg/kg) prolongs mean ERP (11568 versus 14667 ms, P,0.01) and wavelength (8.360.9 versus 9.960.8 cm, P,0.01), reduces dispersion of ERP (1565 versus 861 ms, P,0.01), and minimally slows conduction velocity (7264 versus 6765 cm/s, P,0.01) in pigs. Sulamserod produces no ventricular electrophysiological effects. Sulamserod terminates atrial flutter in 6 of 8 animals and atrial fibrillation in 8 of 9 animals and prevents reinduction of sustained tachycardia in all animals[1].
IC 50
5-HT4 Receptor
References
[1] Rahme MM, et al. Electrophysiological and antiarrhythmic effects of the atrial selective 5-HT(4) receptor antagonist RS-100302 in experimental atrial flutter and fibrillation. Circulation. 1999 Nov 9;100(19):2010-7. DOI:10.1161/01.cir.100.19.2010
SULAMSEROD Preparation Products And Raw materials
Raw materials
Preparation Products
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