5-CHLOROTHIENO[3,2-B]PYRIDINE

Product Name: 5-CHLOROTHIENO[3,2-B]PYRIDINE
CAS No.: 65977-55-1
Chemical Name: 5-CHLOROTHIENO[3,2-B]PYRIDINE
Synonyms: 5-CHLOROTHIENO[3,2-B]PYRIDINE;Thieno[3,2-b]pyridine, 5-chloro-
CBNumber: CB52452853
Molecular Formula: C7H4ClNS
Formula Weight: 169.63
MOL File: 65977-55-1.mol

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5-CHLOROTHIENO[3,2-B]PYRIDINE Property

storage temp.: 2-8°C(protect from light)
Appearance: White to off-white Solid
InChI: InChI=1S/C7H4ClNS/c8-7-2-1-6-5(9-7)3-4-10-6/h1-4H
InChIKey: DINNLDMXTNAIQE-UHFFFAOYSA-N
SMILES: C12C=CSC1=CC=C(Cl)N=2

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Safety

HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C611325
Product name: 5-chlorothieno[3,2-b]pyridine
Packaging: 1g
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0050506
Product name: 5-Chlorothieno[3,2-b]pyridine
Packaging: 100mg
Price: $68
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC165736
Product name: 5-Chlorothieno[3,2-b]pyridine
Packaging: 50mg
Price: $80
Updated: 2021/12/16

ChemScene

Product number: CS-0050506
Product name: 5-Chlorothieno[3,2-b]pyridine
Packaging: 250mg
Price: $113
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC165736
Product name: 5-Chlorothieno[3,2-b]pyridine
Packaging: 100mg
Price: $125
Updated: 2021/12/16

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5-CHLOROTHIENO[3,2-B]PYRIDINE Chemical Properties,Usage,Production

Synthesis

59445-83-9

65977-55-1

The reaction was carried out with 1-(3-thienyl)ethanone oxime (250 mg, 1.77 mmol) in polyphosphoric acid (1.5 mL) at 100 °C with stirring for 30 min. After completion of the reaction, the reaction solution was poured into saturated aqueous sodium carbonate solution and extracted twice with ethyl acetate. The organic phases were combined, washed sequentially with water and saturated saline, and concentrated. The residue was purified by silica gel column chromatography with ethyl acetate:hexane (3:1) as eluent, and the fraction containing the target product was collected and concentrated. The concentrated residue was dissolved in 1,2-dichloroethane (1.5 mL), and a solution of phosphoryl chloride (225 μL, 2.24 mmol) and N,N-dimethylformamide (63 μL, 0.81 mmol) in 1,2-dichloroethane (0.5 mL), which had been pre-cooled to 0 °C, was slowly added. The reaction solution was stirred for 15 min at room temperature and then heated and refluxed for 16 hr. At the end of the reaction, the reaction solution was poured into water (10 mL) containing sodium acetate (550 mg, 4.05 mmol) and the mixture was stirred at 100 °C for 20 min. After cooling, water (25 mL) was added and extracted twice with ethyl acetate. The organic phases were combined, washed sequentially with saturated aqueous sodium bicarbonate and saturated saline, dried over anhydrous sodium sulfate and concentrated to afford 5-chlorothieno[3,2-b]pyridine 115 mg (38% yield) as a light yellow oil, which solidified on standing. The product was characterized by 1H NMR (400 MHz, CDCl3) and ESI-LCMS: 1H NMR δ 8.12 (d, J = 9 Hz, 1H), 7.80 (d, J = 5 Hz, 1H), 7.50 (d, J = 5 Hz, 1H), 7.28 (d, J = 9 Hz, 1H); ESI-LCMS m/z 170 ([M+H]+) .

References

[1] Patent: WO2008/157270, 2008, A1. Location in patent: Page/Page column 90-91

5-CHLOROTHIENO[3,2-B]PYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-CHLOROTHIENO[3,2-B]PYRIDINE Suppliers

China 51 India 1 United Kingdom 1 United States 6 Global 59

Alchem Pharmtech,Inc.

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Matrix Scientific

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65977-55-1, 5-CHLOROTHIENO[3,2-B]PYRIDINERelated Search:

5-CHLOROTHIENO[3,2-B]PYRIDINE 5,7-DICHLORO-2-METHYLTHIENO[3,2-B]PYRIDINE METHYL 5-CHLORO-2-METHYL-7-(TRIFLUOROMETHYL)THIENO[3,2-B]PYRIDINE-3-CARBOXYLATE METHYL 5-CHLORO-7-(TRIFLUOROMETHYL)THIENO[3,2-B]PYRIDINE-3-CARBOXYLATE 5-CHLORO-7-METHOXYTHIENO[3,2-B]PYRIDINE 5-CHLORO-7-(TRIFLUOROMETHYL)THIENO[3,2-B]PYRIDINE-3-CARBOXYLIC ACID 5,7-DICHLORO-3-METHYLTHIENO[3,2-B]PYRIDINE 5,7-DICHLOROTHIENO[3,2-B]PYRIDINE AKOS 93181

5-CHLOROTHIENO[3,2-B]PYRIDINE

Thieno[3,2-b]pyridine, 5-chloro-

65977-55-1