5-BROMO-1H-PYRAZOLO[3,4-B]PYRIDINE-3-CARBOXYLIC ACID
- Product Name
- 5-BROMO-1H-PYRAZOLO[3,4-B]PYRIDINE-3-CARBOXYLIC ACID
- CAS No.
- 916325-85-4
- Chemical Name
- 5-BROMO-1H-PYRAZOLO[3,4-B]PYRIDINE-3-CARBOXYLIC ACID
- Synonyms
- 5-BROMO-1H-PYRAZOLO[3,4-B]PYRIDINE-3-CARBOXYLIC ACID;5-bromo-2H-pyrazolo[3,4-b]pyridine-3-carboxylic acid;1H-Pyrazolo[3,4-b]pyridine-3-carboxylic acid, 5-broMo-
- CBNumber
- CB52455339
- Molecular Formula
- C7H4BrN3O2
- Formula Weight
- 242.03
- MOL File
- 916325-85-4.mol
5-BROMO-1H-PYRAZOLO[3,4-B]PYRIDINE-3-CARBOXYLIC ACID Property
- Boiling point:
- 492.3±40.0 °C(Predicted)
- Density
- 2.068±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 1.89±0.30(Predicted)
- Appearance
- White to yellow Solid
Safety
- RIDADR
- UN2811
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CS-0037491
- Product name
- 5-Bromo-1H-pyrazolo[3,4-b]pyridine-3-carboxylicacid
- Purity
- >97.0%
- Packaging
- 250mg
- Price
- $97
- Updated
- 2021/12/16
- Product number
- CS-0037491
- Product name
- 5-Bromo-1H-pyrazolo[3,4-b]pyridine-3-carboxylicacid
- Purity
- >97.0%
- Packaging
- 100mg
- Price
- $78
- Updated
- 2021/12/16
- Product number
- CS-0037491
- Product name
- 5-Bromo-1H-pyrazolo[3,4-b]pyridine-3-carboxylicacid
- Purity
- >97.0%
- Packaging
- 1g
- Price
- $186
- Updated
- 2021/12/16
- Product number
- 5433AC
- Product name
- 5-Bromo-1H-pyrazolo[3,4-b]pyridine-3-carboxylicacid
- Packaging
- 1g
- Price
- $288
- Updated
- 2021/12/16
- Product number
- 068520
- Product name
- 5-Bromo-1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid
- Purity
- >95%
- Packaging
- 250mg
- Price
- $567
- Updated
- 2021/12/16
5-BROMO-1H-PYRAZOLO[3,4-B]PYRIDINE-3-CARBOXYLIC ACID Chemical Properties,Usage,Production
Synthesis
916325-84-3
916325-85-4
General procedure for the synthesis of 5-bromo-1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid using methyl 5-bromo-1H-pyrazolo[3,4-b]pyridine-3-carboxylate: 5-bromo-1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid methyl ester (3.4 g, 13.2 mmol) was dissolved in methanol (50 mL), and 2M sodium hydroxide solution ( 10 mL) and the reaction was refluxed for 4 hours. After completion of the reaction, the mixture was cooled to room temperature, acidified with hydrochloric acid to pH<7, precipitated as a solid, and filtered to afford 5-bromo-1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid (3.22 g, 100% yield). The product was characterized by 1H NMR (300 MHz, CD3OD): δ 8.62 (s, 1H), 8.58 (s, 1H); mass spectrometry (ESI) m/z: 359 (M+H+).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 15, p. 4297 - 4302
[2] Patent: WO2006/130673, 2006, A1. Location in patent: Page/Page column 74
[3] Patent: WO2011/84486, 2011, A1. Location in patent: Page/Page column 106; 112-113
[4] Patent: US2013/296302, 2013, A1. Location in patent: Paragraph 0499
[5] Patent: US2016/68550, 2016, A1. Location in patent: Paragraph 1061
5-BROMO-1H-PYRAZOLO[3,4-B]PYRIDINE-3-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-BROMO-1H-PYRAZOLO[3,4-B]PYRIDINE-3-CARBOXYLIC ACID manufacturers
- Product
- 5-BROMO-1H-PYRAZOLO[3,4-B]PYRIDINE-3-CARBOXYLIC ACID 916325-85-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 97%-98%
- Supply Ability
- 200KG
- Release date
- 2019-09-03