1H-Pyrazolo[3,4-b]pyridine-3-carboxylicacid(9CI)

Product Name: 1H-Pyrazolo[3,4-b]pyridine-3-carboxylicacid(9CI)
CAS No.: 116855-08-4
Chemical Name: 1H-Pyrazolo[3,4-b]pyridine-3-carboxylicacid(9CI)
Synonyms: 1H-Pyrazolo[3,4-b]pyridin-3-carboxylic acid;2h-pyrazolo[3,4-b]pyridine-3-carboxylic Acid;1H-Pyrazolo[3,4-b]pyridine-3-carboxylicacid(9CI);1H-Pyrazolo[3,4-b]pyridine-3-carboxylic acid ,97%;1H-Pyrazolo[3,4-b]pyridine-3-carboxylic acid (9CI, ACI)
CBNumber: CB91285429
Molecular Formula: C7H5N3O2
Formula Weight: 163.13
MOL File: 116855-08-4.mol

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1H-Pyrazolo[3,4-b]pyridine-3-carboxylicacid(9CI) Property

Melting point:: 265-270℃ (DEC.)
Boiling point:: 391.1±25.0 °C(Predicted)
Density: 1.68
storage temp.: 2-8°C
pka: 8.83±0.20(Predicted)
Appearance: Light yellow to brown Solid
InChI: InChI=1S/C7H5N3O2/c11-7(12)5-4-2-1-3-8-6(4)10-9-5/h1-3H,(H,11,12)(H,8,9,10)
InChIKey: UFKAACYLUOQSFH-UHFFFAOYSA-N
SMILES: C12NN=C(C(O)=O)C1=CC=CN=2

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Safety

Risk Statements: 20/21/22
Safety Statements: 24/25-36/37
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: P840440
Product name: 1H-Pyrazolo[3,4-b]pyridine-3-carboxylicAcid
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Apolloscientific

Product number: OR305633
Product name: 1H-Pyrazolo[3,4-b]pyridine-3-carboxylic acid
Packaging: 250mg
Price: $65
Updated: 2021/12/16

AK Scientific

Product number: X9182
Product name: 1H-Pyrazolo[3,4-b]pyridine-3-carboxylicacid
Packaging: 250mg
Price: $103
Updated: 2021/12/16

Matrix Scientific

Product number: 040865
Product name: 1H-Pyrazolo[3,4-b]pyridine-3-carboxylic acid
Packaging: 1g
Price: $108
Updated: 2021/12/16

Apolloscientific

Product number: OR305633
Product name: 1H-Pyrazolo[3,4-b]pyridine-3-carboxylic acid
Packaging: 1g
Price: $144
Updated: 2021/12/16

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1H-Pyrazolo[3,4-b]pyridine-3-carboxylicacid(9CI) Chemical Properties,Usage,Production

Chemical Properties

Light yellow solid

Uses

1h-Pyrazolo[3,4-B]Pyridine-3-Carboxylic Acid is a useful research chemical.

Synthesis

116834-96-9

116855-08-4

Step 4: To an aqueous solution (20 mL) containing NaOH (0.88 g, 22 mmol) was added 3-methyl-1H-pyrazolo[3,4-b]pyridine (IV) (0.4 g, 3 mmol). The suspension was heated at 80°C until a clarified solution was formed. Subsequently, an aqueous solution (180 mL) of KMnO4 (1.73 g, 11 mmol) was added slowly over a period of 2 hours while keeping the solution heated at 80°C. The solution was heated at 90°C for 2 hours. The reaction mixture was continued to be heated at 90°C for 2 hours until the complete disappearance of the feedstock was confirmed by thin layer chromatography (TLC). The solution was cooled to 70°C and filtered through a diatomaceous earth pad. The solids were washed with boiling water. The filtrates were combined and cooled to 0°C and acidified with concentrated HCl to pH=2. The acidified solution was extracted with n-butanol (2 x 10 mL). The n-butanol layer was concentrated under reduced pressure to give a white residue. The residue was dissolved in dichloromethane (DCM), a minimum amount of methanol (MeOH) was added to aid solubilization, and then filtered. The filtrate was concentrated to afford 1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid (V) as a white solid (390 mg, 2.39 mmol, 81% yield).1H NMR (CDCl3) δ ppm: 7.37 (dd, J = 8.10, 4.52 Hz, 1H), 8.47 (dd, J = 7.54, 1.88 Hz, 1H), 8.62 (dd, J = 7.54, 1.88 Hz, 1H), 8.63 (dd, J = 7.54, 1.88 Hz, 1H). 8.62 (dd, J = 4.52, 1.32 Hz, 1H), 14.37 (brs, 1H).

References

[1] Patent: WO2011/84486, 2011, A1. Location in patent: Page/Page column 106; 111-112
[2] Patent: US2013/296302, 2013, A1. Location in patent: Paragraph 0496
[3] Patent: US2016/68550, 2016, A1. Location in patent: Paragraph 1058
[4] Patent: WO2016/40193, 2016, A1. Location in patent: Paragraph 0705
[5] Canadian Journal of Chemistry, 1988, vol. 66, # 3, p. 420-428

1H-Pyrazolo[3,4-b]pyridine-3-carboxylicacid(9CI) Preparation Products And Raw materials

Raw materials

Hydrazinium hydroxide solution Ethanol Zinc chloride Polyphosphoric acid 1-Pentanol 3-Aminocrotononitrile Potassium permanganate 1,1,3,3-Tetramethoxypropane 3-Amino-5-methylpyrazole

Preparation Products

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1H-Pyrazolo[3,4-b]pyridine-3-carboxylicacid(9CI) Suppliers

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View Lastest Price from 1H-Pyrazolo[3,4-b]pyridine-3-carboxylicacid(9CI) manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 1H-Pyrazolo[3,4-b]pyridine-3-carboxylicacid(9CI) 116855-08-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-13

Career Henan Chemical Co

Product: 1H-Pyrazolo[3,4-b]pyridine-3-carboxylicacid(9CI) 116855-08-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 97-99%
Supply Ability: 1000KGS
Release date: 2019-12-18

116855-08-4, 1H-Pyrazolo[3,4-b]pyridine-3-carboxylicacid(9CI)Related Search:

3-deazaadenine 1H-PYRROLO[2,3-C]PYRIDINE-2-CARBOXYLIC ACID 2-Cyanopyridine 1H-PYRAZOLO[3,4-B]PYRIDINE 1H-Pyrazolo[3,4-b]pyridine-3-carboxylicacid(9CI) 5-BROMO-1H-PYRAZOLO[3,4-B]PYRIDINE-3-CARBOXYLIC ACID TERT-BUTYL 6-FLUORO-1H-PYRAZOLO[3,4-B]PYRIDINE-3-CARBOXYLATE 1-METHYL-1H-PYRAZOLO[3,4-B]PYRIDINE-3-CARBOXYLIC ACID 1H-PYRAZOLO[3,4-B]PYRIDINE-3-CARBALDEHYDE

1H-Pyrazolo[3,4-b]pyridine-3-carboxylicacid(9CI)

1H-Pyrazolo[3,4-b]pyridine-3-carboxylic acid ,97%

1H-Pyrazolo[3,4-b]pyridin-3-carboxylic acid

2h-pyrazolo[3,4-b]pyridine-3-carboxylic Acid

1H-Pyrazolo[3,4-b]pyridine-3-carboxylic acid (9CI, ACI)

116855-08-4

GLYCINESCAFFOLD

Heterocycle-Pyridine series