1H-PYRAZOLO[3,4-B]PYRIDINE

Product Name: 1H-PYRAZOLO[3,4-B]PYRIDINE
CAS No.: 271-73-8
Chemical Name: 1H-PYRAZOLO[3,4-B]PYRIDINE
Synonyms: 7-Azaindazole;7-Aza-1H-indazole;Pyrazolo[3,4-b]pyridine;1H-PYRAZO[3,4-B]PYRIDINE;Pyrazolo[3,4-b]pyridine>1H-PYRAZOLO[3,4-B]PYRIDINE;1H-Pyrazolo[3,4-b]pyridine ,97%;1H-pyrazolo[3,4-b]pyridine(SALTDATA: FREE)
CBNumber: CB9422236
Molecular Formula: C6H5N3
Formula Weight: 119.12
MOL File: 271-73-8.mol

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1H-PYRAZOLO[3,4-B]PYRIDINE Property

Melting point:: 99-101°C
Boiling point:: 120°C/0.1mmHg(lit.)
Density: 1.38±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform, Ethyl Acetate
pka: 5.92±0.20(Predicted)
form: Solid
color: reddish-brown
InChI: InChI=1S/C6H5N3/c1-2-5-4-8-9-6(5)7-3-1/h1-4H,(H,7,8,9)
InChIKey: GVLRTOYGRNLSDW-UHFFFAOYSA-N
SMILES: C12NN=CC1=CC=CN=2

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Safety

Hazard Codes: Xn
Risk Statements: 22-20/21/22
Safety Statements: 36/37
TSCA: No
HS Code: 29331990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: P2285
Product name: Pyrazolo[3,4-b]pyridine
Purity: >98.0%(HPLC)(T)
Packaging: 200mg
Price: $41
Updated: 2025/07/31

TCI Chemical

Product number: P2285
Product name: Pyrazolo[3,4-b]pyridine
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $139
Updated: 2025/07/31

Usbiological

Product number: 003008
Product name: 7-Azaindazole
Packaging: 250mg
Price: $396
Updated: 2021/12/16

Matrix Scientific

Product number: 067203
Product name: 1H-Pyrazolo[3,4-b]pyridine
Purity: 95+%
Packaging: 1g
Price: $18
Updated: 2021/12/16

ChemScene

Product number: CS-W000643
Product name: 1H-Pyrazolo[3,4-b]pyridine
Purity: 99.98%
Packaging: 5g
Price: $33
Updated: 2021/12/16

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1H-PYRAZOLO[3,4-B]PYRIDINE Chemical Properties,Usage,Production

Chemical Properties

Pale Orange Solid

Uses

A pyrazole derivative as kinase inhibitors.

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 7, p. 247, 1970 DOI: 10.1002/jhet.5570070146

Synthesis

36404-88-3

271-73-8

General procedure for the synthesis of 1H-pyrazolo[3,4-b]pyridine from 2-chloro-3-pyridinecarboxaldehyde: Hydrazine hydrate (10 mL) was added to a mixture of 2-chloro-3-formylpyridine (5.00 g, 35 mmol) and p-toluenesulfonic acid (3.50 g, 18 mmol). The reaction mixture was stirred at 130 °C for 3 hours. Upon completion of the reaction, the mixture was cooled with cold water and subsequently extracted with ethyl acetate. The organic phases were combined and dried with anhydrous magnesium sulfate. After filtration, the solvent was removed by distillation under reduced pressure to afford the target compound 1H-pyrazolo[3,4-b]pyridine (3.65 g, 87% yield) as a yellow solid. The melting point of the compound was 88-90 °C (literature value 97-98 °C). Its Fourier transform infrared spectrum (KBr) showed characteristic absorption peaks: νmax/cm-1 3450 (NH), 3089, 3026 (aromatic CH), 2958, 2915 (CH), 1606, 1588, 1509, 1470, 1429 (C=N, C=C). The NMR hydrogen spectrum (300 MHz, CDCl3) data are as follows: δ/ppm 1.69 (s, 1H, NH), 7.19 (dd, 1H, J=4.7 and 7.5 Hz, ArH, 5-H), 8.12 (s, 1H, ArH, 3-H), 8.15 (d, 1H, J=8.1 Hz, ArH, 4-H), 8.63 (d, 1H, J=4.5Hz, ArH, 6-H).

References

[1] European Journal of Medicinal Chemistry, 2012, vol. 57, p. 311 - 322
[2] Journal of Organic Chemistry, 2017, vol. 82, # 23, p. 12300 - 12306
[3] Journal of the Brazilian Chemical Society, 2013, vol. 24, # 8, p. 1295 - 1306
[4] Patent: EP1921078, 2008, A1. Location in patent: Page/Page column 32
[5] Patent: US2007/21442, 2007, A1. Location in patent: Page/Page column 56

1H-PYRAZOLO[3,4-B]PYRIDINE Preparation Products And Raw materials

Raw materials

3-Aminopyrazole Ethanol Zinc chloride 1,1,3,3-Tetramethoxypropane

Preparation Products

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1H-PYRAZOLO[3,4-B]PYRIDINE Suppliers

Belgium 1 Canada 3 China 178 France 3 Germany 3 India 6 Italy 1 Japan 2 Switzerland 1 United Kingdom 8 United States 37 Global 243

J & K SCIENTIFIC LTD.

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View Lastest Price from 1H-PYRAZOLO[3,4-B]PYRIDINE manufacturers

Jiangsu Magic Biotechnology Co., Ltd

Product: 1H-PYRAZOLO[3,4-B]PYRIDINE 271-73-8
Price: US $0.00-0.00/kg
Min. Order: 25kg
Purity: 99%
Supply Ability: 20tons
Release date: 2023-05-04

Unipharm pharmaceutical industry Co., Ltd

Product: 1H-Pyrazolo[3,4-b]pyridine 271-73-8
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2023-03-22

Career Henan Chemical Co

Product: 1H-PYRAZOLO[3,4-B]PYRIDINE 271-73-8
Price: US $1.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 100KG
Release date: 2018-12-22

271-73-8, 1H-PYRAZOLO[3,4-B]PYRIDINERelated Search:

4-(BUTYLAMINO)-1-ETHYL-6-METHYL 1H-PYRAZOLO[3,4B]PYRIDINE-5-ETHYLCARBOXYLATE HYDROCHLORIDE ETHYL 4-CHLORO-1,3-DIMETHYL-1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLATE 4-CHLORO-1,3-DIMETHYLPYRAZOLO[3,4-B]PYRIDINE-5-CARBONYL CHLORIDE 4-CHLORO-1,3-DIMETHYLPYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLIC ACID ETHYL PYRAZOLO[1,5-A]PYRIDINE-3-CARBOXYLATE Pyrazolo[1,5-a]pyridine 3-Iodo-7-aza-1H-azaindazole 1H-Pyrrolo[2,3-b]pyridine, 5-(trifluoromethyl)- 6-chloroH-pyrazolo[1,5-a]pyridine-2-carboxylic acid 1H-PYRAZOLO[3,4-B]PYRIDINE, 3-BROMO- Pyrazolo[1,5-a]pyridin-3-ylmethanol ethyl 1H-pyrazolo[3,4-c]pyridine-3-carboxylate 2-Mercapto-5-methoxyimidazole[4,5-b]pyridine 4,5,6,7-TETRAHYDRO-2-METHYL-2H-PYRAZOLO[4,3-C]PYRIDINE DIHYDROCHLORIDE Pyrazolo[1,5-a]pyridin-2-ylmethanol 1H-Pyrazolo[3,4-b]pyridine,3-methyl-(9CI) 1H-PYRAZOLO[4,3-B]PYRIDINE Pyrazolo[1,5-a]pyridine-2-carboxylic acid

1H-PYRAZOLO[3,4-B]PYRIDINE

1H-PYRAZO[3,4-B]PYRIDINE

1H-Pyrazolo[3,4-b]pyridine ,97%

7-Azaindazole

1H-pyrazolo[3,4-b]pyridine(SALTDATA: FREE)

7-Aza-1H-indazole

Pyrazolo[3,4-b]pyridine

Pyrazolo[3,4-b]pyridine&gt

271-73-8

271-73-4

271-71-8

271-37-8

Heterocycle-Pyridine series

Heterocycles

Inhibitors

Intermediates & Fine Chemicals

Pharmaceuticals