ChemicalBook > CAS DataBase List > 1H-Pyrazolo[3,4-b]pyridine,3-methyl-(9CI)

1H-Pyrazolo[3,4-b]pyridine,3-methyl-(9CI)

Product Name
1H-Pyrazolo[3,4-b]pyridine,3-methyl-(9CI)
CAS No.
116834-96-9
Chemical Name
1H-Pyrazolo[3,4-b]pyridine,3-methyl-(9CI)
Synonyms
3-methyl-1H-pyrazolo[3,4-b]pyridine;3-METHYL-2H-PYRAZOLO[3,4-B]PYRIDINE;1H-Pyrazolo[3,4-b]pyridine,3-Methyl-;3-methyl-1H-pyrazolo[3,4-b]pyridine (en);3-Methyl-1H-pyrazolo[3,4-b]pyridine ,97%;1H-Pyrazolo[3,4-b]pyridine,3-methyl-(9CI);1H-Pyrazolo[3,4-b]pyridine,3-methyl-(9CI) ISO 9001：2015 REACH
CBNumber
CB01292862
Molecular Formula
C7H7N3
Formula Weight
133.15
MOL File
116834-96-9.mol
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1H-Pyrazolo[3,4-b]pyridine,3-methyl-(9CI) Property

Melting point:
158-160°
Boiling point:
255.7±23.0 °C(Predicted)
Density 
1.31±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
6.52±0.20(Predicted)
Appearance
Light yellow to yellow Solid
CAS DataBase Reference
116834-96-9
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Safety

Risk Statements 
20/21/22
Safety Statements 
36/37
HazardClass 
IRRITANT
HS Code 
29331990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
M330373
Product name
3-Methyl-1H-pyrazolo[3,4-b]pyridine
Packaging
500mg
Price
$110
Updated
2021/12/16
Apolloscientific
Product number
OR33616
Product name
3-Methyl-1H-pyrazolo[3,4-b]pyridine
Packaging
1g
Price
$163
Updated
2021/12/16
Matrix Scientific
Product number
046732
Product name
3-Methyl-1H-pyrazolo[3,4-b]pyridine
Purity
>95%
Packaging
500mg
Price
$29
Updated
2021/12/16
Matrix Scientific
Product number
046732
Product name
3-Methyl-1H-pyrazolo[3,4-b]pyridine
Purity
>95%
Packaging
1g
Price
$44
Updated
2021/12/16
SynQuest Laboratories
Product number
3H32-1-B3
Product name
3-Methyl-1H-pyrazolo[3,4-b]pyridine
Packaging
1g
Price
$90
Updated
2021/12/16
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1H-Pyrazolo[3,4-b]pyridine,3-methyl-(9CI) Chemical Properties,Usage,Production

Chemical Properties

White solid

Synthesis

55676-21-6

116834-96-9

Step 3: Synthesis of 3-methyl-1H-pyrazolo[3,4-b]pyridine 1-(2-chloropyridin-3-yl)ethanone (22 g, 0.1415 mol) was dissolved with 98% hydrazine hydrate (113 g, 2.21 mol) in ethanol (300 mL) and reacted at reflux for 12 hours. Upon completion of the reaction, about 80% of the ethanol was removed by distillation under reduced pressure using a rotary evaporator. The residue was cooled to room temperature and the precipitated solid was collected by filtration and washed with cold water. The resulting product was dried to constant weight at 90 °C to give 3-methyl-1H-pyrazolo[3,4-b]pyridine (16 g, 85% yield) with a melting point of 152-154 °C. 1H NMR (CDCl3) δ: 8.62 (dd, J = 4.5, 1.4 Hz, 1H), 8.08 (dd, J = 8.0, 1.4 Hz, 1H), 7.15 (dd, J = 8.0, 4.5 Hz, 1H), 2.64 (s, 3H). MS (FAB) m/z: 133 (M++1).

References

[1] European Journal of Medicinal Chemistry, 2012, vol. 57, p. 311 - 322
[2] Patent: US2006/47126, 2006, A1. Location in patent: Page/Page column 30
[3] Patent: WO2011/5759, 2011, A2. Location in patent: Page/Page column 77-78
[4] Canadian Journal of Chemistry, 1988, vol. 66, # 3, p. 420-428
[5] Patent: WO2011/84486, 2011, A1. Location in patent: Page/Page column 106; 111

1H-Pyrazolo[3,4-b]pyridine,3-methyl-(9CI) Preparation Products And Raw materials

Raw materials

Ethanol Zinc chloride Polyphosphoric acid 1,1,3,3-Tetramethoxypropane 3-Amino-5-methylpyrazole

Preparation Products

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1H-Pyrazolo[3,4-b]pyridine,3-methyl-(9CI) Suppliers

China 125 Europe 1 India 2 United Kingdom 2 United States 10 Global 140
Shanghai Boyle Chemical Co., Ltd.
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View Lastest Price from 1H-Pyrazolo[3,4-b]pyridine,3-methyl-(9CI) manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
1H-Pyrazolo[3,4-b]pyridine,3-methyl-(9CI) 116834-96-9
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-13
Dideu Industries Group Limited
Product
1H-Pyrazolo[3,4-b]pyridine,3-methyl-(9CI) 116834-96-9
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-10-25
Career Henan Chemical Co
Product
1H-Pyrazolo[3,4-b]pyridine,3-methyl-(9CI) 116834-96-9
Price
US $1.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
200kg
Release date
2018-12-24

116834-96-9, 1H-Pyrazolo[3,4-b]pyridine,3-methyl-(9CI)Related Search:

4-CHLORO-1,3-DIMETHYLPYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLIC ACID 4-CHLORO-1,3-DIMETHYLPYRAZOLO[3,4-B]PYRIDINE-5-CARBONYL CHLORIDE ETHYL 4-CHLORO-1,3-DIMETHYL-1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLATE 1H-PYRAZOLO[3,4-B]PYRIDINE ETHYL 1,3-DIMETHYL-4-(4-FLUOROPHENOXY)-1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLATE 6-HYDRAZINO-1,3,4-TRIMETHYL-1H-PYRAZOLO[3,4-B]PYRIDINE 1,3-DIMETHYL-1H-PYRAZOLO[3,4-B]PYRIDIN-4-OL ETHYL 4-(4-METHOXYPHENOXY)-1,3-DIMETHYL-1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLATE ETHYL 4-(3,5-DICHLOROPHENOXY)-1,3-DIMETHYL-1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLATE O1-[(4-CHLORO-1,3-DIMETHYL-1H-PYRAZOLO[3,4-B]PYRIDIN-5-YL)CARBONYL]-4-CHLOROBENZENE-1-CARBOHYDROXIMAMIDE O-[1,4-DIMETHYL-3-(2-THIENYL)-1H-PYRAZOLO[3,4-B]PYRIDIN-6-YL] O,O-DIETHYL PHOSPHOTHIOATE N5-(2-CHLOROPHENYL)-4-CHLORO-1,3-DIMETHYL-1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXAMIDE O1-[(4-CHLORO-1,3-DIMETHYL-1H-PYRAZOLO[3,4-B]PYRIDIN-5-YL)CARBONYL]-4-(TRIFLUOROMETHYL)BENZENE-1-CARBOHYDROXIMAMIDE N-[(4-CHLORO-1,3-DIMETHYL-1H-PYRAZOLO[3,4-B]PYRIDIN-5-YL)CARBONYL]-N'-[3,5-DI(TRIFLUOROMETHYL)PHENYL]UREA N5-(1-METHYL-1-OXO-1-PHENYL-LAMBDA6-SULPHANYLIDENE)-6-CHLORO-1,3-DIMETHYL-1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXAMIDE N-[(4-CHLORO-1,3-DIMETHYL-1H-PYRAZOLO[3,4-B]PYRIDIN-5-YL)CARBONYL]-N'-(4-FLUOROPHENYL)UREA 6-CHLORO-1,4-DIMETHYL-3-(2-THIENYL)-1H-PYRAZOLO[3,4-B]PYRIDINE 4-CHLORO-1,3-DIMETHYL-1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXAMIDE

  • 1H-Pyrazolo[3,4-b]pyridine,3-methyl-(9CI)
  • 3-methyl-1H-pyrazolo[3,4-b]pyridine
  • 3-Methyl-1H-pyrazolo[3,4-b]pyridine ,97%
  • 3-methyl-1H-pyrazolo[3,4-b]pyridine (en)
  • 1H-Pyrazolo[3,4-b]pyridine,3-Methyl-
  • 3-METHYL-2H-PYRAZOLO[3,4-B]PYRIDINE
  • 1H-Pyrazolo[3,4-b]pyridine,3-methyl-(9CI) ISO 9001：2015 REACH
  • 116834-96-9
  • Heterocycle-Pyridine series
  • PYRIDINE