2-Mercapto-5-methoxyimidazole[4,5-b]pyridine

Uses

Product Name: 2-Mercapto-5-methoxyimidazole[4,5-b]pyridine
CAS No.: 113713-60-3
Chemical Name: 2-Mercapto-5-methoxyimidazole[4,5-b]pyridine
Synonyms: TENA-003;(4,5-b)pyridine;1,3-dihydro-5-methoxy-;2-Mercapto-5-Methoxypyridine;2-Mercapto-5-methoxyimidazoL;2-Mercapto-5-methoxy-imidazo[4;2H-Imidazo[4,5-b] pyridine-2-thione;5-Methoxy-2-thio-3H-imidazo[4,5-b]pyridine;2-MERCAPTO-5-METHOXYIMIDAZOE[4,5-B]PYRIDINE;5-Methoxy-3H-imidazo[4,5-b]pyridine-2-thiol
CBNumber: CB3738771
Molecular Formula: C7H7N3OS
Formula Weight: 181.21
MOL File: 113713-60-3.mol

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2-Mercapto-5-methoxyimidazole[4,5-b]pyridine Property

Melting point:: 238-241°C
Boiling point:: 324.9±52.0 °C(Predicted)
Density: 1.55±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: powder
pka: 7.39±0.40(Predicted)
color: Off white to beige
CAS DataBase Reference: 113713-60-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
HazardClass: IRRITANT
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Matrix Scientific

Product number: 024748
Product name: 2-Mercapto-5-methoxyimidazol(4,5-b)pyridine
Packaging: 5.00g
Price: $51
Updated: 2026/05/18

Crysdot

Product number: CD11348192
Product name: 2-Mercapto-5-methoxyimidazole[4,5-b]pyridine
Purity: 97%
Packaging: 100g
Price: $317
Updated: 2026/05/27

Chemenu

Product number: CM175778
Product name: 5-methoxy-1H-imidazo[4,5-b]pyridine-2-thiol
Purity: 95%+
Packaging: 25g
Price: $90
Updated: 2026/05/26

Arctom

Product number: BD-A117283
Product name: 2-Mercapto-5-methoxyimidazole[4,5-b]pyridine
Purity: 97%
Packaging: 1g
Price: $17
Updated: 2026/05/26

Arctom

Product number: BD-A117283
Product name: 2-Mercapto-5-methoxyimidazole[4,5-b]pyridine
Purity: 97%
Packaging: 5g
Price: $20
Updated: 2026/05/26

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2-Mercapto-5-methoxyimidazole[4,5-b]pyridine Chemical Properties,Usage,Production

Uses

2-Mercapto-5-methoxyimidazolium[4,5-b]pyridine is a pyridine derivative that can be used as a pharmaceutical intermediate.

Chemical Properties

White to gray solid

Synthesis

75-15-0

28020-38-4

113713-60-3

2-Mercapto-5-methoxyimidazo[4,5-b]pyridine (Compound 9c) was synthesized in five steps, methoxylation, nitration, amination, reduction and cyclization, using 2,6-dichloropyridine as starting material in 45.7% overall yield. The structure of the product was confirmed by 1H NMR, mass spectrometry (MS) and infrared spectroscopy (IR). The procedure was as follows: 6-methoxy-3-nitropyridin-2-amine (0.5 g, 3 mmol) was dissolved in a mixed solvent of methanol (100 mL) and water (2 mL), 10% Pd/C catalyst (0.1 g) was added, and the reaction was carried out in a hydrogenation unit under hydrogen (3 bar) atmosphere with shaking until the pressure was constant. After completion of the reaction, the catalyst was removed by filtration and carbon disulfide (1 mL) and potassium hydroxide (0.225 g) were added to the filtrate and refluxed under heat. The progress of the reaction was monitored by thin layer chromatography (TLC), and after completion of the reaction the solvent was removed by concentration under reduced pressure. The resulting solid was recrystallized from ethanol to afford the target product 2-mercapto-5-methoxyimidazo[4,5-b]pyridine (0.187 g, 1.1 mmol) in 35% yield with a melting point of 223-225 °C. IR (cm-1 ): 3262, 3051. 1H NMR (200 MHz, DMSO-d6) δ (ppm): 12.99 (s, 1H , NH), 12.54 (s, 1H, NH), 7.43-7.47 (d, 1H, J = 8.5 Hz, Harom.), 6.55-6.60 (d, 1H, J = 8.5 Hz, Harom.), 3.83 (s, 3H, CH3).13C NMR (50 MHz, DMSO-d6) δ (ppm): 167.60, 160.12, 143.62, 120.17, 119.65, 103.90, 53.49.

References

[1] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 12, p. 3669 - 3677
[2] Journal of Medicinal Chemistry, 2014, vol. 57, # 23, p. 10080 - 10100
[3] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 5, p. 1371 - 1375
[4] Journal of Medicinal Chemistry, 2017, vol. 60, # 14, p. 6289 - 6304

2-Mercapto-5-methoxyimidazole[4,5-b]pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Mercapto-5-methoxyimidazole[4,5-b]pyridine Suppliers

China 108 Europe 2 Germany 3 India 9 Japan 1 Ukraine 1 United Kingdom 11 United States 27 Global 162

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View Lastest Price from 2-Mercapto-5-methoxyimidazole[4,5-b]pyridine manufacturers

Qingdao RENAS Polymer Material Co., Ltd.

Product: 2-Mercapto-5-methoxyimidazole-[4,5-b]pyridine 113713-60-3
Price: US $0.00/kg
Min. Order: 20kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2024-11-12

Career Henan Chemical Co

Product: 2-Mercapto-5-methoxyimidazole[4,5-b]pyridine 113713-60-3
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: Customized
Release date: 2018-12-22

113713-60-3, 2-Mercapto-5-methoxyimidazole[4,5-b]pyridineRelated Search:

2-Ethylhexyl mercaptoacetate Ornidazole Calcium thioglycolate 6-Mercaptopurine Sodium thioglycolate 2-Pyridinethione Mercaptoacetic acid POTASSIUM THIOGLYCOLATE Methimazole Pyridine 3-Mercaptopropionic acid Tenatoprazole 2-Mercaptoethanol 5-METHOXY-2-[[(4-METHOXY-3,5-DIMETHYL-2-PYRIDINYL)METHYL]THIO]-1H-IMIDAZO[4,5B]PYRIDINE Malathion 2-Mercapto-5-methoxyimidazole[4,5-n]pyridine 2-Mercapto-5-methoxyimidazole[4,5-b]pyridine 5-METHOXY-1H-IMIDAZO[4,5-B]PYRIDINE-2-THIOL

2-Mercapto-5-methoxy-imidazo[4

2-Mercapto-5-methoxyimidazole-[4,5-b]pyridine(MIPT)

2-mercapto-5-methoxyimidazole-[4,5-b]pyridine (intermediate of tenatoprazole)

2-MERCAPTO-5-METHOXYIMIDAZOE[4,5-B]PYRIDINE

2-Mercapto-5-Methoxypyridine

1,3-Dihydro-5-Methoxy-2H-Imidazo(4,5-b)Pyridine-2-Thione 2-mercapto-5-methoxyimidazole-[4,5-b]pyridine

2-MERCAPTO-5-METHOXYIMIDAZOLE-[4,5-B]PYRIDINE 98+%

2-MERCAPTO-5-METHOXYIMIDAZOLE-[4,5-B]PYRIDINE(TENATOPRAZOLE INTERMEDIATE)

TENA-003

2-Mercapto-5-methoxy-3H-imidazo[4,5-b]pyridine

5-Methoxy-3H-imidazo[4,5-b]pyridine-2-thiol

1,3-dihydro-5-methoxy-

2H-Imidazo[4,5-b] pyridine-2-thione

2-Mercapto-5-methoxy-3H-imidazole-[4,5-b]pyridine ,98%

2-MERCAPTO-5-METHOXYIMIDAZOL(4,5-B)PYRIDINE

2-MERCAPTO-5-METHOXYIMIDAZOLE-[4,5-B]PYRIDINE

5-Methoxy-4H-iMidazo[4,5-b]pyridine-2-thiol

2-Mercapto-5-methoxy-3H-imidazo[4,5-b]pyridine, 5-Methoxy-3H-imidazo[4,5-b]pyridine-2-thiol

5-Methoxy-2-thio-3H-imidazo[4,5-b]pyridine

1,3-Dihydro-5-Methoxy-2H-Imidazo(4,5-b)Pyridine-2-Thione

2H-Imidazo[4,5-b]pyridine-2-thione, 1,3-dihydro-5-methoxy-

5-MethoxyiMidazo-[4,5-b]pyridine-2-thiol (InterMediate of TTZ) 2-Mercapto-5-MethoxyiMidazole[4,5-b]pyridine

,3-Dihydro-5-Methoxy-2H-Imidazo(4,5-b)Pyridine-2-Thione

(4,5-b)pyridine

2-Mercapto-5-methoxyimidazoL

113713-60-3

C7H7N3OS

Heterocycle-Pyridine series

(intermediate of tenatoprazole)

Imidazoles