2-Mercapto-5-methoxyimidazole[4,5-b]pyridine

Uses

Product Name: 2-Mercapto-5-methoxyimidazole[4,5-b]pyridine
CAS No.: 113713-60-3
Chemical Name: 2-Mercapto-5-methoxyimidazole[4,5-b]pyridine
Synonyms: TENA-003;(4,5-b)pyridine;1,3-dihydro-5-methoxy-;2-Mercapto-5-Methoxypyridine;2-Mercapto-5-methoxyimidazoL;2-Mercapto-5-methoxy-imidazo[4;2H-Imidazo[4,5-b] pyridine-2-thione;5-Methoxy-2-thio-3H-imidazo[4,5-b]pyridine;2-MERCAPTO-5-METHOXYIMIDAZOE[4,5-B]PYRIDINE;5-Methoxy-3H-imidazo[4,5-b]pyridine-2-thiol
CBNumber: CB3738771
Molecular Formula: C7H7N3OS
Formula Weight: 181.21
MOL File: 113713-60-3.mol

More

Less

2-Mercapto-5-methoxyimidazole[4,5-b]pyridine Property

Melting point:: 238-241°C
Boiling point:: 324.9±52.0 °C(Predicted)
Density: 1.55±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: powder
pka: 7.39±0.40(Predicted)
color: Off white to beige
CAS DataBase Reference: 113713-60-3(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
HazardClass: IRRITANT
HS Code: 29333990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More

Less

N-Bromosuccinimide Price

TRC

Product number: B481453
Product name: 2-Mercapto-5-methoxyimidazole[4,5-b]pyridine
Packaging: 50mg
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: J56854
Product name: 2-Mercapto-5-methoxyimidazole-[4,5-b]pyridine
Packaging: 25g
Price: $121
Updated: 2021/12/16

Apolloscientific

Product number: OR12659
Product name: 5-Methoxy-2-thio-3H-imidazo[4,5-b]pyridine
Packaging: 25g
Price: $129
Updated: 2021/12/16

SynQuest Laboratories

Product number: 8H61-1-X5
Product name: 5-Methoxy-2-thio-3H-imidazo[4,5-b]pyridine
Packaging: 25g
Price: $152
Updated: 2021/12/16

Apolloscientific

Product number: OR12659
Product name: 5-Methoxy-2-thio-3H-imidazo[4,5-b]pyridine
Packaging: 5g
Price: $41
Updated: 2021/12/16

More

Less

2-Mercapto-5-methoxyimidazole[4,5-b]pyridine Chemical Properties,Usage,Production

Uses

2-Mercapto-5-methoxyimidazolium[4,5-b]pyridine is a pyridine derivative that can be used as a pharmaceutical intermediate.

Chemical Properties

White to gray solid

Synthesis

75-15-0

28020-38-4

113713-60-3

2-Mercapto-5-methoxyimidazo[4,5-b]pyridine (Compound 9c) was synthesized in five steps, methoxylation, nitration, amination, reduction and cyclization, using 2,6-dichloropyridine as starting material in 45.7% overall yield. The structure of the product was confirmed by 1H NMR, mass spectrometry (MS) and infrared spectroscopy (IR). The procedure was as follows: 6-methoxy-3-nitropyridin-2-amine (0.5 g, 3 mmol) was dissolved in a mixed solvent of methanol (100 mL) and water (2 mL), 10% Pd/C catalyst (0.1 g) was added, and the reaction was carried out in a hydrogenation unit under hydrogen (3 bar) atmosphere with shaking until the pressure was constant. After completion of the reaction, the catalyst was removed by filtration and carbon disulfide (1 mL) and potassium hydroxide (0.225 g) were added to the filtrate and refluxed under heat. The progress of the reaction was monitored by thin layer chromatography (TLC), and after completion of the reaction the solvent was removed by concentration under reduced pressure. The resulting solid was recrystallized from ethanol to afford the target product 2-mercapto-5-methoxyimidazo[4,5-b]pyridine (0.187 g, 1.1 mmol) in 35% yield with a melting point of 223-225 °C. IR (cm-1 ): 3262, 3051. 1H NMR (200 MHz, DMSO-d6) δ (ppm): 12.99 (s, 1H , NH), 12.54 (s, 1H, NH), 7.43-7.47 (d, 1H, J = 8.5 Hz, Harom.), 6.55-6.60 (d, 1H, J = 8.5 Hz, Harom.), 3.83 (s, 3H, CH3).13C NMR (50 MHz, DMSO-d6) δ (ppm): 167.60, 160.12, 143.62, 120.17, 119.65, 103.90, 53.49.

References

[1] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 12, p. 3669 - 3677
[2] Journal of Medicinal Chemistry, 2014, vol. 57, # 23, p. 10080 - 10100
[3] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 5, p. 1371 - 1375
[4] Journal of Medicinal Chemistry, 2017, vol. 60, # 14, p. 6289 - 6304

2-Mercapto-5-methoxyimidazole[4,5-b]pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

2-Mercapto-5-methoxyimidazole[4,5-b]pyridine Suppliers

China 110 Europe 2 Germany 3 India 9 Japan 1 Ukraine 1 United Kingdom 11 United States 27 Global 164

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

INTATRADE GmbH

Tel: +49 3493/605464
Fax: +49 3493/605470
Email: sales@intatrade.de
Country: Germany
ProdList: 3572
Advantage: 66

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10186
Advantage: 62

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14101
Advantage: 59

Shanghai Longsheng chemical Co.,Ltd.

Tel: 021-58099652-8005 13585536065
Fax: 021-58099609
Email: bin.wu@shlschem.com
Country: China
ProdList: 9883
Advantage: 59

Beijing Isomersyn Technology CO;LTD

Tel: 010-82954736 13391601435
Email: sales@isomersyn.com
Country: China
ProdList: 3295
Advantage: 57

More

Less

View Lastest Price from 2-Mercapto-5-methoxyimidazole[4,5-b]pyridine manufacturers

Qingdao RENAS Polymer Material Co., Ltd.

Product: 2-Mercapto-5-methoxyimidazole-[4,5-b]pyridine 113713-60-3
Price: US $0.00/kg
Min. Order: 20kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2024-11-12

Career Henan Chemical Co

Product: 2-Mercapto-5-methoxyimidazole[4,5-b]pyridine 113713-60-3
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: Customized
Release date: 2018-12-22

113713-60-3, 2-Mercapto-5-methoxyimidazole[4,5-b]pyridineRelated Search:

2-Ethylhexyl mercaptoacetate Ornidazole Calcium thioglycolate 6-Mercaptopurine Sodium thioglycolate 2-Pyridinethione Mercaptoacetic acid POTASSIUM THIOGLYCOLATE Methimazole Pyridine 3-Mercaptopropionic acid Tenatoprazole 2-Mercaptoethanol 5-METHOXY-2-[[(4-METHOXY-3,5-DIMETHYL-2-PYRIDINYL)METHYL]THIO]-1H-IMIDAZO[4,5B]PYRIDINE Malathion 2-Mercapto-5-methoxyimidazole[4,5-n]pyridine 2-Mercapto-5-methoxyimidazole[4,5-b]pyridine 5-METHOXY-1H-IMIDAZO[4,5-B]PYRIDINE-2-THIOL

2-Mercapto-5-methoxy-imidazo[4

2-Mercapto-5-methoxyimidazole-[4,5-b]pyridine(MIPT)

2-mercapto-5-methoxyimidazole-[4,5-b]pyridine (intermediate of tenatoprazole)

2-MERCAPTO-5-METHOXYIMIDAZOE[4,5-B]PYRIDINE

2-Mercapto-5-Methoxypyridine

1,3-Dihydro-5-Methoxy-2H-Imidazo(4,5-b)Pyridine-2-Thione 2-mercapto-5-methoxyimidazole-[4,5-b]pyridine

2-MERCAPTO-5-METHOXYIMIDAZOLE-[4,5-B]PYRIDINE 98+%

2-MERCAPTO-5-METHOXYIMIDAZOLE-[4,5-B]PYRIDINE(TENATOPRAZOLE INTERMEDIATE)

TENA-003

2-Mercapto-5-methoxy-3H-imidazo[4,5-b]pyridine

5-Methoxy-3H-imidazo[4,5-b]pyridine-2-thiol

1,3-dihydro-5-methoxy-

2H-Imidazo[4,5-b] pyridine-2-thione

2-Mercapto-5-methoxy-3H-imidazole-[4,5-b]pyridine ,98%

2-MERCAPTO-5-METHOXYIMIDAZOL(4,5-B)PYRIDINE

2-MERCAPTO-5-METHOXYIMIDAZOLE-[4,5-B]PYRIDINE

5-Methoxy-4H-iMidazo[4,5-b]pyridine-2-thiol

2-Mercapto-5-methoxy-3H-imidazo[4,5-b]pyridine, 5-Methoxy-3H-imidazo[4,5-b]pyridine-2-thiol

5-Methoxy-2-thio-3H-imidazo[4,5-b]pyridine

1,3-Dihydro-5-Methoxy-2H-Imidazo(4,5-b)Pyridine-2-Thione

2H-Imidazo[4,5-b]pyridine-2-thione, 1,3-dihydro-5-methoxy-

5-MethoxyiMidazo-[4,5-b]pyridine-2-thiol (InterMediate of TTZ) 2-Mercapto-5-MethoxyiMidazole[4,5-b]pyridine

,3-Dihydro-5-Methoxy-2H-Imidazo(4,5-b)Pyridine-2-Thione

(4,5-b)pyridine

2-Mercapto-5-methoxyimidazoL

113713-60-3

C7H7N3OS

Heterocycle-Pyridine series

(intermediate of tenatoprazole)

Imidazoles