Description Indications Contraindications Dosage Information Mechanism of Action Drug Interactions Warnings Pharmacokinetics Side Effects
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Ornidazole

Description Indications Contraindications Dosage Information Mechanism of Action Drug Interactions Warnings Pharmacokinetics Side Effects
Product Name
Ornidazole
CAS No.
16773-42-5
Chemical Name
Ornidazole
Synonyms
OPSS;1-Chloro-3-(2-Methyl-5-nitro-1H-iMidazol-1-yl)propan-2-ol;tiberal;alpha-(chlormethyl)-2-methyl-5-nitro-imidazol-1-aethanol;Ornidazol a-(ChloroMethyl)-2-Methyl-5-nitro-1H-iMidazole-1-ethanol;Madelen;Ornidal;ro7-0207;NSC 95075;Ornidazol
CBNumber
CB5735895
Molecular Formula
C7H10ClN3O3
Formula Weight
219.63
MOL File
16773-42-5.mol
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Ornidazole Property

Melting point:
85-90°C
Boiling point:
443.2±40.0 °C(Predicted)
Density 
1.6545 (rough estimate)
refractive index 
1.6000 (estimate)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Soluble in ethanol at 50mg/ml
pka
2.4 ± 0.1(at 25℃)
form 
Solid
color 
Crystals from toluene
λmax
276nm(H2SO4 aq.)(lit.)
Merck 
14,6872
InChIKey
IPWKIXLWTCNBKN-UHFFFAOYSA-N
CAS DataBase Reference
16773-42-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
36
WGK Germany 
3
RTECS 
NI5460000
HS Code 
2933.29.4300
HazardClass 
IRRITANT
Toxicity
LD50 in rats, mice (mg/kg): 1780, 1420 orally (Grunberg); LD50 in mice (mg/kg): >2000 orally, >2000 i.p. (Hoffer, Grunberg)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P330Rinse mouth.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
O5879
Product name
Ornidazole
Purity
analytical standard
Packaging
5g
Price
$80.4
Updated
2024/03/01
TCI Chemical
Product number
O0417
Product name
Ornidazole
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$26
Updated
2024/03/01
TCI Chemical
Product number
O0417
Product name
Ornidazole
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$58
Updated
2024/03/01
Alfa Aesar
Product number
J63100
Product name
Ornidazole, 99%
Packaging
5g
Price
$64.9
Updated
2024/03/01
Alfa Aesar
Product number
J63100
Product name
Ornidazole, 99%
Packaging
25g
Price
$261
Updated
2024/03/01
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Ornidazole Chemical Properties,Usage,Production

Description

Ornidazole is prescribed for the treatment of certain protozoan infections, post-surgery infections and bacterial infections. The action of this drug is based on its potential to inhibit the development of microorganisms. Ornidazole is available as an oral tablet that should be taken based on a pharmacist/doctor’s instructions. Prescriptions that include this drug should also take into consideration some of the patient’s specifications such as hypersensitivity and potential drug interactions.

Indications

Ornidazole is given to patients who have vaginal infections such as bacterial vaginitis, post-surgical infections, anaerobic bacterial infections, skin infections, trichomonas vaginitis, intestinal infections, stomach infections, parasitic infections and bacterial infections. It is highly recommended that this drug is taken under appropriate diagnosis and medical indication.

Contraindications

It is not recommended to take this medicine if one is hypersensitive to similar antibiotics, or if one has a history of hypersensitivity. Other than hypersensitivity, this drug is contraindicated in lactating/pregnant women, and in patients with epilepsy, myasthenia gravis and multiple sclerosis.

Dosage Information

For the treatment of amoebiasis, adult patients should take 1g daily in 2 doses for 7-10 days whereas children should be given 10-25mg/kg once a day for 3 days.
For treatment of amoebic dysentery, adults should take 1.5mg once a day for 3 days whereas children should be given 40mg/kg once per day for 3 days.
The typical Ornidazole dosage for treatment of trichomoniasis in adults is 0.5gm once every 12 hours/1.5gm as a single dose for 5 days. In children, 25mg/kg can be taken as a single dose.
For treatment of Giardiasis in adults, 1-1.5gm should be taken once per day for 2 days and in children, 40mg/kg should be taken for two days.
The dosage requirements for the treatment of bacterial vaginitis is 1.5gm, which is taken once every day or 500mg taken as a daily single dose for 5-7 days.
In the event of a missed dose, supportive and symptomatic treatment should be commenced where the Ornidazole is removed through gastric lavage, induced emesis, application of a carthartic or administration of activated charcoal.

Mechanism of Action

The drug is a nitroimidazole with broad spectrum cidal action against specific types of anaerobic bacteria and protozoa. Ornidazole’s selective toxicity in response to anaerobic microbes entails entry of the drug into the cell through diffusion and reduction of the drug’s nitro group into reactive nitro by redox proteins in anaerobic organisms. This activity influences cytotoxic action by destroying DNA and other fundamental molecules. The final step entails destabilization of the DNA helix and the breakage of certain strands.

Drug Interactions

Some medications have a higher probability of interacting with other prescription drugs hence the doctor should approve any medication adjustments. It is essential for a patient to notify their doctor of any medication, herbal treatments and vitamin supplements that they may be taking before the administration of Ornidazole. A prompt notification may minimize the probability of occurrence of specific side effects.
Ornidazole may interact with warfarin and vecuronium.

Warnings

It is recommended that a patient abstains from alcohol intake for at least 3 days after initiation of therapy with this drug. Alcohol use or associated products may influence disulfiram-like responses in some people.
Ornidazole use in pregnant/breastfeeding women is not recommended as the potential risks may outweigh the benefits in some cases. However, a patient should always consult their healthcare practitioner before taking this medication.
The use of Ornidazole may result in drowsiness hence a patient should avoid activities such as the operation of heavy machinery and driving during the first stages of treatment with this drug.
Caution should be taken amongst patients with multiple sclerosis as it is a neurodegenerative disorder associated with the brain. Ornidazole should not be prescribed for patients with convulsion disorders such as epilepsy.
For patients with hepatic/renal impairment, the drug should be used cautiously as it may intensify the severity of the pre-existing condition. In this case, it is recommended that the patient is monitored frequently by their doctor for mild to moderate impairment and the respective dose modifications.

Pharmacokinetics

Ornidazole is absorbed well orally, and it is widely distributed through the body. The drug undergoes metabolism in the liver and part of the drug is excreted in bile whereas the rest is eliminated in urine. The duration of action of the drug is 14 hours.

Side Effects

In the administration of medications to treat specific medical conditions, there is a high probability that unintended side effects will develop. Patients on Ornidazole treatment may experience some of the associated side effects in varying intensities. However, if the symptoms persist for an extended period, the patient should contact their doctor.
Potential side effects may include hormonal imbalances in the thyroid gland, skin rash, urticaria, abdominal distress, vertigo metallic taste, dry mouth, upset stomach, drowsiness, headache and nausea.

Description

Ornidazole is an orally bioavailable 5-nitroimidazole derivative with antibacterial and antiprotozoal activities. Ornidazole inhibits the growth of clinical isolates of B. fragilis (MICs = 0.5-5 μM) and various anaerobic bacteria when used at concentrations ranging from less than 0.1 to 3.2 μg/ml. It also inhibits the growth of Giardia isolates (IC50s = 0.01-0.47 μg/ml). Oral administration of ornidazole reduces T. vaginalis and T. foetus infection in mice and E. histolytica infection in rats with curative dose (CD50) values of 37, 3, and 10 mg/kg, respectively. Ornidazole (400 mg/kg per day) induces infertility in male rats within 7 days and inhibits spermatozoa binding to rat oocyte zona pellucida.

Chemical Properties

Crystalline Solid

Originator

Tiberal,Roche,W. Germany ,1977

Uses

Ornidazole is a drug that cures some protozoan infections. It has been investigated for use in Crohn's disease after bowel resection. It is indicated in treatment of mixed amoebiasis, mixed amoebic dysentery, mixed giardiasis, trichomoniasis, bacterial vaginosis, Sexually transmitted diseases, infections of gynaecology, lower respiratory tract infections, ENT, surgical and dental infections.

Uses

Anti-infective

Uses

estrogen

Definition

ChEBI: A C-nitro compound that is 5-nitroimidazole in which the hydrogens at positions 1 and 2 are replaced by 3-chloro-2-hydroxypropyl and methyl groups, respectively. It is used in the treatment of susceptible protozoal infections and for the treatment of anaerobic bacterial infections.

Manufacturing Process

5g of 1-(2,3-epoxypropyl)-2-methyl-5-nitroimidazole was added to 30 ml of concentrated aqueous hydrochloric acid. The solution was heated to the boiling point for 20 minutes, chilled, diluted with 30 ml of water and carefully neutralized with ammonia to a pH of 7 to 8. It was then saturated with ammonium sulfate. The precipitated oil crystallized after several days. Recrystallized from toluene, there was obtained the 1-(3-chloro-2hydroxypropyl)-2-methyl-5-nitroimidazole product melting at 77°C to 78°C.

Therapeutic Function

Antiinfective

Pharmaceutical Applications

A 5-nitroimidazole available for oral administration, intravenous infusion and as a vaginal pessary. Its activity closely parallels that of metronidazole and tinidazole.
Peak plasma levels after a single 750 mg or 1.5 g oral dose reach 11 mg/L and 30 mg/L, respectively, within about 2 h. The half-life is 12–14 h. It is well absorbed from the vagina, with peak plasma concentrations of 5 mg/L being reached 12 h after the insertion of a 500 mg vaginal pessary. After a single 1 g intravenous infusion for colorectal surgery, serum levels reached about 24 mg/L after 15 min and about 6 mg/L after 24 h. It has wide tissue distribution, including CSF. Plasma protein binding is 10–15%.
It is metabolized in the liver, mainly to hydroxymethyl derivatives. The plasma clearance rate decreases in hepatic failure because of reduced liver metabolism and decreased biliary elimination. About 60% of an oral dose is recovered in the urine and 20% in the feces. The dosing interval should be doubled in patients with severe hepatic impairment, but it is unnecessary to reduce the dose in patients with impaired renal function. It is removed by hemodialysis.
Toxicity and side effects are similar to those of metronidazole and tinidazole and it has similar clinical uses. It has been shown to be effective for the prevention of recurrence of Crohn’s disease after ileocolonic resection.

Safety Profile

Poison by intravenous route. Moderately toxic by ingestion and intraperitoneal routes. Experimental reproductive effects. Mutation data reported. Whenheated to decomposition it emits very toxic fumes of Clí and NOx.

Ornidazole Preparation Products And Raw materials

Raw materials

Preparation Products

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Ornidazole Suppliers

Hubei widely chemical technology Co., Ltd.
Tel
027-83989310 18627915365
Fax
027-83989310
Email
2658488909@qq.com
Country
China
ProdList
1297
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58
Wuhan ze shan cheng Biomedical Technology Co., Ltd.
Tel
027-51477051 17786425391
Fax
027-51477052
Email
jim@zeshancheng.com
Country
China
ProdList
369
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58
Huadong Medicine (Xi'an)Bodyguard Pharmaceutical Co.,Ltd.
Tel
029-86638659 18109298458
Email
50844069@qq.com
Country
China
ProdList
17
Advantage
58
Hubei Hicks Biochemical Co., Ltd
Tel
17362916295; 17362916295
Email
w17362916295@163.com
Country
China
ProdList
4046
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3572
Advantage
66
future industrial shanghai co., ltd
Tel
400-0066400 13621662912
Fax
021-55660885
Email
sales@jonln.com
Country
China
ProdList
1995
Advantage
65
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2338
Advantage
56
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Beijing HwrkChemical Technology Co., Ltd
Tel
010-89508211 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
8415
Advantage
55
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View Lastest Price from Ornidazole manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Ornidazole 16773-42-5
Price
US $1.00/Kg/Bag
Min. Order
1KG
Purity
98.0%min
Supply Ability
100kgmonth
Release date
2021-06-05
Hangzhou Hyper Chemicals Limited
Product
Ornidazole 16773-42-5
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%, USP
Supply Ability
5,000KG
Release date
2024-08-02
Hebei Dangtong Import and export Co LTD
Product
Ornidazole 16773-42-5
Price
US $50.00-40.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20Tons
Release date
2023-10-10

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