ChemicalBook > CAS DataBase List > 1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER

1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER

Product Name
1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER
CAS No.
5952-93-2
Chemical Name
1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER
Synonyms
Methyl 1-methyl-4-pyrazolecarboxylate;Methyl 1-Methyl-1H-pyrazole-4-carboxylate;methyl 1-methylpyrazole-4-carboxylate;Methyl 1-methyl-1H-pyrazol-4-carboxylate;methyl 1-methylpyrazole-4-carboxylate - [M87048];1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER;1-methyl-1H-Pyrazole-4-carboxylic acid methyl ester (9CI ACI);1H-Pyrazole-4-carboxylic acid, 1-methyl-, methyl ester (9CI, ACI)
CBNumber
CB52455733
Molecular Formula
C6H8N2O2
Formula Weight
140.14
MOL File
5952-93-2.mol
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1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER Property

Melting point:
62.0-62.5 °C
Boiling point:
221.6±13.0 °C(Predicted)
Density 
1.18±0.1 g/cm3(Predicted)
storage temp. 
Store at room temperature
pka
-0.01±0.10(Predicted)
Appearance
Off-white to light yellow Solid
InChI
InChI=1S/C6H8N2O2/c1-8-4-5(3-7-8)6(9)10-2/h3-4H,1-2H3
InChIKey
HGQQQXMARFJNCP-UHFFFAOYSA-N
SMILES
N1(C)C=C(C(OC)=O)C=N1
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Safety

HS Code 
2933199090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC
Product number
M338513
Product name
Methyl1-Methyl-1H-pyrazole-4-carboxylate
Packaging
100mg
Price
$60
Updated
2021/12/16
Apolloscientific
Product number
OR955457
Product name
Methyl1-methyl-1H-pyrazole-4-carboxylate
Purity
98%
Packaging
1g
Price
$203
Updated
2021/12/16
Matrix Scientific
Product number
113997
Product name
Methyl 1-methyl-1H-pyrazole-4-carboxylate
Purity
97%
Packaging
1g
Price
$260
Updated
2021/12/16
Apolloscientific
Product number
OR955457
Product name
Methyl1-methyl-1H-pyrazole-4-carboxylate
Purity
98%
Packaging
5g
Price
$609
Updated
2021/12/16
AK Scientific
Product number
8860AB
Product name
Methyl1-methyl-1H-pyrazole-4-carboxylate
Packaging
10g
Price
$728
Updated
2021/12/16
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1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER Chemical Properties,Usage,Production

Synthesis

5952-92-1

18107-18-1

5952-93-2

Step A: Trimethylsilylated diazomethane (12.0 mL, 24 mmol, 2.0 M hexane solution) was slowly added dropwise to a solution of 1-methyl-4-pyrazolecarboxylic acid (0.59 g, 4.7 mmol) in methanol (20 mL) at 0 °C through an addition funnel. The reaction mixture was stirred at the same temperature for 20 min followed by concentration. The crude product was partitioned between ethyl acetate (100 mL) and water (50 mL). The organic phase was dried over anhydrous sodium sulfate, filtered and concentrated. The crude product was purified by fast column chromatography using hexane/ethyl acetate (4:1, v/v) as eluent to afford methyl 1-methyl-1H-pyrazole-4-carboxylate (0.50 g, 3.6 mmol, 76% yield) as a white solid. Mass spectrum (APCI-positive ion mode) m/z: [M+1]+ = 141.1.

References

[1] Patent: WO2011/25951, 2011, A1. Location in patent: Page/Page column 54

1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER Suppliers

China 55 India 1 United Kingdom 1 United States 5 Global 62
Changzhou hanergy Biotechnology Co., Ltd
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13915872857
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hannengchemical@163.com
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China
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Pure Chemistry Scientific Inc.
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sales@chemreagents.com
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Nanjing Chemlin Chemical Co., Ltd
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025-83697070
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+86-25-83453306
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China
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China DongFan Chemical Co.,LTD
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86-0571-85151182
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86-0571-85151182
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QINGDAO CARELONGPHARMATECH CO.,LTD
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Acorn PharmaTech Co., Ltd.
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Modachem Shanghai Co., Ltd
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+86 (0)21 51320687 51371369 1744605818
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Nanjing Chalf-Pharm Technology Co., Ltd.
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5952-93-2, 1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTERRelated Search:

ETHYL 1,3,5-TRIMETHYL-1H-PYRAZOLE-4-CARBOXYLATE ETHYL 5-METHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLATE ETHYL 5-AMINO-1-METHYLPYRAZOLE-4-CARBOXYLATE ETHYL 2-PHENYL-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE 5-AMINO-4-CARBETHOXY-1-PHENYLPYRAZOLE 3-AMINO-6-(DIMETHYLAMINO)-1-(4-METHYLPHENYL)PYRAZOLO[3,4-D][1,3]OXAZIN-4(1H)-ONE PYRAZOLE-4-CARBOXYLIC ACID, 3-AMINO-1-METHYL-, ETHYL ESTER ETHYL 1-(2,4-DIFLUOROPHENYL)-5-METHYLPYRAZOLE-4-CARBOXYLATE ETHYL 1-(4-CHLOROPHENYL)-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE ETHYL 1-METHYL-5-(1H-PYRROL-1-YL)-1H-PYRAZOLE-4-CARBOXYLATE METHYL 5-METHYL-1-PHENYLPYRAZOLE-4-CARBOXYLATE ETHYL 1-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-5-METHYL-1H-PYRAZOLE-4-CARBOXYLATE ETHYL 5-AMINO-1-(1,3-DIMETHYL-4-NITROPYRAZOL-5-YL)PYRAZOLE-4-CARBOXYLATE ethyl 5-hydroxy-1-phenyl-1H-pyrazole-4-carboxylate ETHYL 1-(6-CHLOROPYRIDAZIN-3-YL)-5-METHYL-1H-PYRAZOLE-4-CARBOXYLATE ETHYL 5-AMINO-1-[5,7-BIS(TRIFLUOROMETHYL)[1,8]NAPHTHYRIDIN-2-YL]-1H-PYRAZOLE-4-CARBOXYLATE ETHYL 1-METHYL-5-[(2,3,3-TRICHLOROACRYLOYL)AMINO]-1H-PYRAZOLE-4-CARBOXYLATE ETHYL 1-(2,3,3-TRICHLOROACRYLOYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE

  • Methyl 1-methyl-4-pyrazolecarboxylate
  • methyl 1-methylpyrazole-4-carboxylate
  • 1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER
  • Methyl 1-Methyl-1H-pyrazole-4-carboxylate
  • 1H-Pyrazole-4-carboxylic acid, 1-methyl-, methyl ester (9CI, ACI)
  • 1-methyl-1H-Pyrazole-4-carboxylic acid methyl ester (9CI ACI)
  • methyl 1-methylpyrazole-4-carboxylate - [M87048]
  • Methyl 1-methyl-1H-pyrazol-4-carboxylate
  • 5952-93-2