BENZOOXAZOLE-2-CARBOXYLIC ACID METHYL ESTER
- Product Name
- BENZOOXAZOLE-2-CARBOXYLIC ACID METHYL ESTER
- CAS No.
- 27383-86-4
- Chemical Name
- BENZOOXAZOLE-2-CARBOXYLIC ACID METHYL ESTER
- Synonyms
- Methyl 2-benzoxazolecarboxylate;Methyl benzo[d]oxazole-2-carboxylate;Methyl 1,3-benzoxazole-2-carboxylate;2-Benzoxazolecarboxylic acid, Methyl ester;BENZOOXAZOLE-2-CARBOXYLIC ACID METHYL ESTER
- CBNumber
- CB52456750
- Molecular Formula
- C9H7NO3
- Formula Weight
- 177.16
- MOL File
- 27383-86-4.mol
BENZOOXAZOLE-2-CARBOXYLIC ACID METHYL ESTER Property
- Melting point:
- 99 °C
- Boiling point:
- 272.3±23.0 °C(Predicted)
- Density
- 1.288±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 0.14±0.10(Predicted)
- Appearance
- White to light brown Solid
- InChI
- InChI=1S/C9H7NO3/c1-12-9(11)8-10-6-4-2-3-5-7(6)13-8/h2-5H,1H3
- InChIKey
- YDKNBNOOCSNPNS-UHFFFAOYSA-N
- SMILES
- O1C2=CC=CC=C2N=C1C(OC)=O
Safety
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M220193
- Product name
- MethylBenzo[D]oxazole-2-carboxylate
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- M220193
- Product name
- MethylBenzo[D]oxazole-2-carboxylate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- W5049
- Product name
- Methylbenzo[d]oxazole-2-carboxylate
- Packaging
- 250mg
- Price
- $135
- Updated
- 2021/12/16
- Product number
- CS-0061868
- Product name
- Methyl2-benzoxazolecarboxylate
- Packaging
- 1g
- Price
- $182
- Updated
- 2021/12/16
- Product number
- CS-0061868
- Product name
- Methyl2-benzoxazolecarboxylate
- Packaging
- 250mg
- Price
- $91
- Updated
- 2021/12/16
BENZOOXAZOLE-2-CARBOXYLIC ACID METHYL ESTER Chemical Properties,Usage,Production
Uses
Methyl Benzo[D]oxazole-2-carboxylate is used as a reactant in the preparation of benzoxazole-based oxadiazoles as antimicrobial agents.
Synthesis
273-53-0
124-38-9
74-88-4
27383-86-4
Catalyst (9.9 mg, 0.025 mmol, 5 mol%), potassium tert-butoxide (0.0672 g, 0.6 mmol) and DMF (3.0 mL) were added to the reaction flask under argon protection. Benzoxazole (50.7 μL, 0.5 mmol) was then added and carbon dioxide gas was passed under atmospheric pressure. The reaction mixture was stirred at 80 °C for 18 hours. After completion of the reaction, the temperature was lowered to 65 °C, iodomethane (93 μL, 1.5 mmol) was added, and stirring was continued at 65 °C for 1 h. The reaction was carried out with the aid of deionized water. At the end of the reaction, the reaction was quenched with deionized water and the reaction product was extracted with ethyl acetate. The yield of the product, methyl benzo[d]oxazole-2-carboxylate, was measured to be 95% by gas chromatography analysis. Further purification by column chromatography using ethyl acetate/petroleum ether (1:10, v/v) as the unfolding solvent gave 90% yield of the purified product.
References
[1] Green Chemistry, 2018, vol. 20, # 5, p. 989 - 996
[2] Organic Letters, 2010, vol. 12, # 15, p. 3567 - 3569
[3] Journal of the American Chemical Society, 2010, vol. 132, # 26, p. 8858 - 8859
[4] Patent: CN106565623, 2017, A. Location in patent: Paragraph 0021
[5] Angewandte Chemie - International Edition, 2010, vol. 49, # 46, p. 8670 - 8673
BENZOOXAZOLE-2-CARBOXYLIC ACID METHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
BENZOOXAZOLE-2-CARBOXYLIC ACID METHYL ESTER Suppliers
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View Lastest Price from BENZOOXAZOLE-2-CARBOXYLIC ACID METHYL ESTER manufacturers
- Product
- METHYL BENZO[D]OXAZOLE-2-CARBOXYLATE 27383-86-4
- Price
- US $2.00-6.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-07-30