Methyl benzo[d]oxazole-7-carboxylate

Product Name: Methyl benzo[d]oxazole-7-carboxylate
CAS No.: 1086378-35-9
Chemical Name: Methyl benzo[d]oxazole-7-carboxylate
Synonyms: methyl benzoxazole-7-carboxylate;Methyl 1,3-benzoxazole-7-carboxylate;Methyl benzo[d]oxazole-7-carboxylate;7-Benzoxazolecarboxylic acid, methyl ester
CBNumber: CB62666208
Molecular Formula: C9H7NO3
Formula Weight: 177.16
MOL File: 1086378-35-9.mol

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Methyl benzo[d]oxazole-7-carboxylate Property

Boiling point:: 272.4±13.0 °C(Predicted)
Density: 1.288±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: -0.91±0.30(Predicted)
Appearance: Off-white to light yellow Solid

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Safety

HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

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N-Bromosuccinimide Price

TRC

Product number: M807835
Product name: Methylbenzo[d]oxazole-7-carboxylate
Packaging: 100mg
Price: $65
Updated: 2021/12/16

Apolloscientific

Product number: OR110172
Product name: Methyl 1,3-benzoxazole-7-carboxylate
Packaging: 250mg
Price: $102
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H58-1-HK
Product name: Methyl 1,3-benzoxazole-7-carboxylate
Packaging: 250mg
Price: $120
Updated: 2021/12/16

AK Scientific

Product number: 1714AA
Product name: Methylbenzo[d]oxazole-7-carboxylate
Packaging: 250mg
Price: $127
Updated: 2021/12/16

Apolloscientific

Product number: OR110172
Product name: Methyl 1,3-benzoxazole-7-carboxylate
Packaging: 1g
Price: $192
Updated: 2021/12/16

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Methyl benzo[d]oxazole-7-carboxylate Chemical Properties,Usage,Production

Synthesis

35748-34-6

122-51-0

1086378-35-9

General procedure for the synthesis of methyl benzo[d]oxazole-7-carboxylate from methyl 3-amino-2-hydroxybenzoate and triethyl orthoformate: Methyl 3-amino-2-hydroxybenzoate (1.69 g, 10.13 mmol) was suspended in toluene (2 mL) in a microwave reaction flask. Triethyl orthoformate (1.80 g, 12.15 mmol) and ytterbium trifluoromethanesulfonate (Yb(OTf)3, 0.003 g, 0.005 mmol) were subsequently added. The reaction mixture was microwaved at 100 °C for 1 hour. After completion of the reaction, the solvent was removed by evaporation and the crude product was purified by fast column chromatography (eluent: petroleum ether/ethyl acetate, 4:1, v/v) to afford methyl benzo[d]oxazole-7-carboxylate (1.63 g, 91% yield) as light yellow crystals. The melting point was 116-118 °C (literature value: 9.77 °C).1H NMR (300 MHz, CDCl3) δ 8.21 (s, 1H), 8.04 (dd, J = 7.8, 1.2 Hz, 1H), 7.99 (dd, J = 8.0, 1.2 Hz, 1H), 7.44 (dd, J = 8.0, 7.8 Hz, 1H). 3.76 (s, 3H).13C NMR (75 MHz, CDCl3) δ 180.9, 164.4, 153.4, 141.4, 128.0, 125.6, 124.5, 115.4, 52.6.

References

[1] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 14, p. 3933 - 3937

Methyl benzo[d]oxazole-7-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl benzo[d]oxazole-7-carboxylate Suppliers

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1086378-35-9