Methyl Benzimidazole-5-carboxylate
- Product Name
- Methyl Benzimidazole-5-carboxylate
- CAS No.
- 26663-77-4
- Chemical Name
- Methyl Benzimidazole-5-carboxylate
- Synonyms
- methyl 1H-benzo[d]imidazole-5-carboxylate;methyl 1H-benzo[d]imidazole-6-carboxylate;1H-Benzimidazole-5-carboxylic acid methyl ester;AKOS BBS-00000245;Benzimidazole-5-methyl formate;5-(Methoxycarbonyl)benziMidazole;Methyl 5-BenziMidazolecarboxylate;METHYL BENZIMIDAZOLE-5-CARBOXYLATE;MethylBenzimidazole-5-carboxylate>METHYL 1H-BENZIMIDAZOLE-5-CARBOXYLATE
- CBNumber
- CB7188457
- Molecular Formula
- C9H8N2O2
- Formula Weight
- 176.17
- MOL File
- 26663-77-4.mol
Methyl Benzimidazole-5-carboxylate Property
- Melting point:
- 139 °C
- Boiling point:
- 416.2±18.0 °C(Predicted)
- Density
- 1.324±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- form
- powder to crystal
- pka
- 11.67±0.10(Predicted)
- color
- White to Light yellow to Light orange
- InChI
- InChI=1S/C9H8N2O2/c1-13-9(12)6-2-3-7-8(4-6)11-5-10-7/h2-5H,1H3,(H,10,11)
- InChIKey
- WJHHIVYNOVTVGY-UHFFFAOYSA-N
- SMILES
- C1NC2=CC(C(OC)=O)=CC=C2N=1
Safety
- Hazard Codes
- Xi
- Hazard Note
- Irritant
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- M2582
- Product name
- Methyl Benzimidazole-5-carboxylate
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $90
- Updated
- 2025/07/31
- Product number
- B197025
- Product name
- 1H-Benzimidazole-5-carboxylicAcidMethylEster
- Packaging
- 10g
- Price
- $1055
- Updated
- 2021/12/16
- Product number
- CHM0030423
- Product name
- METHYL 1H-BENZIMIDAZOLE-5-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 2.5G
- Price
- $1065.66
- Updated
- 2021/12/16
- Product number
- CHM0030423
- Product name
- METHYL 1H-BENZIMIDAZOLE-5-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1295.03
- Updated
- 2021/12/16
- Product number
- 075455
- Product name
- Methyl benzimidazole-5-carboxylate
- Purity
- 95+%
- Packaging
- 25g
- Price
- $118
- Updated
- 2021/12/16
Methyl Benzimidazole-5-carboxylate Chemical Properties,Usage,Production
Uses
Methyl Benzimidazole-5-carboxylate can be used as an intermediate used for the synthesis of a number of bioisosteric benzimidazoles as inhibitors of human cytosolic phospholipase A2α.
Synthesis
67-56-1
15788-16-6
26663-77-4
General procedure for the synthesis of methyl benzimidazole-5-carboxylate from methanol and 1H-benzimidazole-5-carboxylic acid: (a) Synthesis of methyl 1H-benzimidazole-5-carboxylate Thionyl chloride (0.135 mL, 1.85 mmol) was slowly added dropwise to a solution of 1H-benzimidazole-5-carboxylic acid (0.300 g, 1.85 mmol) in methanol (50.0 mL). The reaction mixture was refluxed for 12 hours. After completion of the reaction, the mixture was poured into saturated aqueous sodium bicarbonate solution and stirred thoroughly. The organic layer was separated and the aqueous layer was extracted with ethyl acetate (3 x 15 mL). The organic layers were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give a purple solid product in 90% yield. The crude product can be used in subsequent reactions without further purification. [MS (ES+) m/e 177 [M + H]+].
References
[1] Patent: WO2005/82901, 2005, A1. Location in patent: Page/Page column 91
[2] Patent: WO2013/26914, 2013, A1. Location in patent: Page/Page column 125
[3] Patent: WO2007/103755, 2007, A2. Location in patent: Page/Page column 111
[4] Bioorganic and Medicinal Chemistry Letters, 2002, vol. 12, # 20, p. 2925 - 2930
[5] Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 24, p. 3161 - 3164
Methyl Benzimidazole-5-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl Benzimidazole-5-carboxylate manufacturers
- Product
- Methyl Benzimidazole-5-carboxylate 26663-77-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000KGS
- Release date
- 2019-12-30