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Carbendazim

Product Name
Carbendazim
CAS No.
10605-21-7
Chemical Name
Carbendazim
Synonyms
bmk;BCM;MBC;CARBENDAZIN;carbendazime;spin;METHYL 2-BENZIMIDAZOLECARBAMATE;a118;g665;MBCA
CBNumber
CB5416930
Molecular Formula
C9H9N3O2
Formula Weight
191.19
MOL File
10605-21-7.mol
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Carbendazim Property

Melting point:
>300 °C (lit.)
Boiling point:
326.92°C (rough estimate)
Density 
1.4500
vapor pressure 
1.5 x 10-4 Pa (25 °C)
refractive index 
1.6500 (estimate)
Flash point:
11 °C
storage temp. 
-20°C
solubility 
pyridine: soluble1%, clear, very faintly brownish-yellow
pka
4.48(at 25℃)
Water Solubility 
<0.1 g/100 mL at 21 ºC
Merck 
13,1799
BRN 
649044
InChIKey
TWFZGCMQGLPBSX-UHFFFAOYSA-N
LogP
1.4-1.5 at 25℃ and pH5-9
CAS DataBase Reference
10605-21-7(CAS DataBase Reference)
EPA Substance Registry System
Carbendazim (10605-21-7)
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Safety

Hazard Codes 
T,N,F,Xn
Risk Statements 
46-60-61-50/53-39/23/24/25-23/24/25-11-52/53
Safety Statements 
53-45-60-61-36/37-16
RIDADR 
UN 3077 9/PG 3
WGK Germany 
3
RTECS 
DD6500000
HS Code 
29339900
Hazardous Substances Data
10605-21-7(Hazardous Substances Data)
Toxicity
LD50 oral in rabbit: 8160mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H340May cause genetic defects

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P391Collect spillage. Hazardous to the aquatic environment

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR2862
Product name
Fenbendazole Related Compound A
Purity
certified reference material, pharmaceutical secondary standard
Packaging
50MG
Price
$485
Updated
2024/03/01
Sigma-Aldrich
Product number
378674
Product name
Carbendazim
Purity
97%
Packaging
100g
Price
$50.1
Updated
2024/03/01
Sigma-Aldrich
Product number
1269414
Product name
Fenbendazole Related Compound A
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
30mg
Price
$484
Updated
2024/03/01
Sigma-Aldrich
Product number
SRP3010
Product name
BCMA human
Purity
recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
Packaging
20μG
Price
$343
Updated
2023/06/20
Sigma-Aldrich
Product number
F0040010
Product name
Fenbendazole impurity A
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
f0040010
Price
$220
Updated
2024/03/01
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Carbendazim Chemical Properties,Usage,Production

Description

Carbendazim is the degradation product and active ingredient of the carbamate fungicide benomyl. Carbendazim (100 μM) disrupts the growth of S. cerevisiae by inhibiting microtubule polymerization. It impairs meiosis and steroidogenesis in an ex vivo rat model of seminiferous tubules and increases prostate weight in rats when administered at a dose of 100 mg/kg but does not affect other testosterone-dependent or estrogen-dependent tissues.

Chemical Properties

Colorless crystalline solid or light-gray powder. Commercially supplied as dry concentrate that is mixed with water for spraying.

Uses

Carbendazim is the most widely used active ingredient in the benzimidazole class of fungicides. It is a systemic fungicide with both protective and curative activities against a wide range of fungal diseases, especially caused by most Ascomycetes spp. and some Basidiomycetes and Deuteromycetes spp. in a wide variety of crop and ornamental uses.

Definition

ChEBI: A member of the class of benzimidazoles that is 2-aminobenzimidazole in which the primary amino group is substituted by a methoxycarbonyl group. A fungicide, carbendazim controls Ascomycetes, Fungi Imperfecti, and Basidiomy etes on a wide variety of crops, including bananas, cereals, cotton, fruits, grapes, mushrooms, ornamentals, peanuts, sugarbeet, soybeans, tobacco, and vegetables.

General Description

Light gray or beige powder.

Air & Water Reactions

Insoluble in water. Carbendazim slowly decomposes in alkaline solution. .

Reactivity Profile

Carbendazim is a carbamate ester-amine. Amines behave as chemical bases. Carbamates are chemically similar to, but more reactive than amides. Like amides they form polymers such as polyurethane resins. Carbamates are incompatible with strong acids and bases, and especially incompatible with strong reducing agents such as hydrides. Flammable gaseous hydrogen is produced by the combination of active metals or nitrides with carbamates. Strongly oxidizing acids, peroxides, and hydroperoxides are incompatible with carbamates.

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition Carbendazim emits toxic fumes of NOx.

Fire Hazard

Literature sources indicate that Carbendazim is probably nonflammable.

Agricultural Uses

Fungicide: Carbendazim is a systemic fungicide used as a drench to control a broad range of fungi in cereals, vegetables, oilseed rape, sugar beets, grapes, tomatoes, pome fruit and stone fruit. It is also used in post-harvest storage and as treatment in seed pre-planting, frequently in combination with other fungicides. In some areas, it has been used to combat Dutch elm disease.

Trade name

ABACOL®; AIMCOZIM; BAS® 3460; BAS® 67054; BATTAL®; BAVISTIN®; BENDAZIM®; CARBATE®; CARBENDAZIME®; CARBENDAZOL®; CARBENDAZOLE®; CARBENDAZYM®; CARBENDOR; CEKUDAZIM®; CORBEL; CTR® 6669; CUSTOS®; DEFENSOR®; DELSENE®; DEROSAL®; E-965®; DERROPRENE®; EQUITDAZIN®; FUNGISOL®; HOE 17411®; LIGNASAN®; IMISOL®; KEMDAZIN®; MERGAL®; PILLARSTIN®; POLYPHASE®; RODAZIM®; STEMPOR®; SUPERCARB, TRITICOL®; TRITICOL®; U-32.104®

Biochem/physiol Actions

B-cell maturation antigen (BCMA) or tumor necrosis factor receptor superfamily member 17 (TNFRSF17) plays an important role in B cell development, function and regulation. BCMA also has the capability to activate nuclear factor-κB (NF-κB), janus kinase (JNK) and mitogen activated protein kinases (MAPKs). The protein is expressed in certain cancers like glioblastoma, chronic lymphocytic leukemia, Hodgkin lymphoma and multiple myeloma. It has a role in the maintenance of survival of long-lived plasma cells in bone marrow.

Safety Profile

Moderately toxic by skin contact. Mildly toxic by ingestion. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. An agricultural chemical and pesticide. When heated to decomposition it emits toxic fumes of NOx. See also CARBAMATES.

Potential Exposure

Carbendazim is a benzimidazole/carbamate systemic fungicide used as a drench to control a broad range of fungi in cereals, vegetables, oilseed rape, sugar beets, grapes, tomatoes, pome fruit, and stone fruit. It is also used in postharvest storage and as treatment in seed preplanting, frequently in combination with other fungicides. In some areas, it has been used to combat Dutch Elm disease.

Metabolic pathway

When the mites are exposed to 14C-carbendazim, the major carbendazim metabolite identified in the bulb mites is 5-hydroxy-2-aminobenzimidazole. Low levels of 2-aminobenzimidazole and 5-hydroxy-2- benzimidazole carbamate are also identified.

Shipping

UN3082 Environmentally hazardous substances, liquid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required

Degradation

Carbendazim (MBC, 1) was stable in acidic and neutral solutions (pH 5-7, DT50≥57 days at 22°C), but decomposed rapidly with a DT50 of 22 days (WHO, 1993b) to yield 2-aminobenzimidazole (2, Watluns, 1976; Zbozinek, 1984) under alkaline conditions (pH 9). An increase in the salinity of the water accelerated the degradation rate of MBC in water (Deshpande and Patil, 1987).
Photolysis of MBC in natural sunlight is not a significant dissipation mechanism in the environment. Significant degradation did not occur either on leaf surfaces exposed to natural sunlight or in unamended dilute aqueous solution. Degradation occurred in solution under natural sunlight if photoinitiators such as riboflavin or acetone were present (Fleeker and Lacy, 1977).

Incompatibilities

Carbamates are incompatible with reducing agents, strong acids, oxidizing acids, peroxides, and bases. Contact with active metals or nitrides cause the release of flammable, and potentially explosive, hydrogen gas.

Waste Disposal

Do not discharge into drains or sewers. Dispose of waste material as hazardous waste using a licensed disposal contractor to an approved landfill. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Incineration with effluent gas scrubbing is recommended. Containers must be disposed of properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office.

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Carbendazim Suppliers

Hebei Zhentian food additives Co., LTD
Tel
0319-5925599 13373390591
Email
13373390591@163.com
Country
China
ProdList
11447
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44751
Advantage
61
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696;
Email
info@hanhongsci.com
Country
China
ProdList
42982
Advantage
64
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32344
Advantage
50
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18736
Advantage
57
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12990
Advantage
57
BEST-REAGENT
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11726
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14443
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9823
Advantage
79
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View Lastest Price from Carbendazim manufacturers

Wuhan Han Sheng New Material Technology Co.,Ltd
Product
1h-benzimidazole-2-carbamic acid methyl ester 10605-21-7
Price
US $26.59/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000kg
Release date
2023-12-13
Wuhan Han Sheng New Material Technology Co.,Ltd
Product
agrizim 10605-21-7
Price
US $26.57/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000kg
Release date
2023-12-13
Wuhan Han Sheng New Material Technology Co.,Ltd
Product
2- (Methoxycarbonylamino) benzimidazde 10605-21-7
Price
US $26.55/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000kg
Release date
2023-12-13

10605-21-7, CarbendazimRelated Search:


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