5-Amino-1,3-dihydro-2H-benzimidazol-2-one

Product Name: 5-Amino-1,3-dihydro-2H-benzimidazol-2-one
CAS No.: 95-23-8
Chemical Name: 5-Amino-1,3-dihydro-2H-benzimidazol-2-one
Synonyms: AKOS BBS-00006487;5-AMINOBENZIMIDAZOLONE;5-Nitro benzimidazolone;Ilaprazole Impurity 170;5-AMINOBENZIMIDAZOLINONE;5(6)-AMINOBENZOIMIDAZOLONE;5-Aminobenzimidazolone,98%;5-AMino-2-enziMidazolinone;5-AMINO-2-BENZIMIDAZOLINONE;5-Amino-1H-benzimidazol-2-ol
CBNumber: CB8410489
Molecular Formula: C7H7N3O
Formula Weight: 149.15
MOL File: 95-23-8.mol

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5-Amino-1,3-dihydro-2H-benzimidazol-2-one Property

Melting point:: >300 °C
Boiling point:: 201.4±19.0 °C(Predicted)
Density: 1.363±0.06 g/cm3(Predicted)
vapor pressure: 0.001Pa at 20℃
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
form: Powder
pka: 11.80±0.30(Predicted)
color: White to Amber to Dark purple
InChI: InChI=1S/C7H7N3O/c8-4-1-2-5-6(3-4)10-7(11)9-5/h1-3H,8H2,(H2,9,10,11)
InChIKey: BCXSVFBDMPSKPT-UHFFFAOYSA-N
SMILES: C1(=O)NC2=CC=C(N)C=C2N1
LogP: -0.33 at 23℃ and pH6.5-7.5
CAS DataBase Reference: 95-23-8(CAS DataBase Reference)
EPA Substance Registry System: 2H-Benzimidazol-2-one, 5-amino-1,3-dihydro- (95-23-8)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-36-22
Safety Statements: 26-36/37/39
WGK Germany: 3
TSCA: TSCA listed
HazardClass: IRRITANT
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CDS003171
Product name: 5-Amino-1,3-dihydro-2H-benzimidazol-2-one
Purity: Aldrich
Packaging: 1g
Price: $87.5
Updated: 2025/07/31

TCI Chemical

Product number: A1950
Product name: 5-Amino-2-benzimidazolinone
Purity: >98.0%(HPLC)
Packaging: 5g
Price: $16
Updated: 2025/07/31

TCI Chemical

Product number: A1950
Product name: 5-Amino-2-benzimidazolinone
Purity: >98.0%(HPLC)
Packaging: 25g
Price: $22
Updated: 2025/07/31

TRC

Product number: A790310
Product name: 5-Amino-2-hydroxybenzimidazole
Packaging: 1g
Price: $40
Updated: 2021/12/16

TRC

Product number: A790310
Product name: 5-Amino-2-hydroxybenzimidazole
Packaging: 10g
Price: $200
Updated: 2021/12/16

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5-Amino-1,3-dihydro-2H-benzimidazol-2-one Chemical Properties,Usage,Production

Chemical Properties

Crystalline powder

Uses

5-Amino-2-hydroxybenzimidazole is an important reagent in the discovery of potent and selective non-nucleotide small molecule inhibitors of CD73

Synthesis

93-84-5

95-23-8

Step: 21b Synthesis of 5-amino-1,3-dihydrobenzimidazol-2-one. Pd/C catalyst (140 mg) was added to a mixed solution of methanol and ethyl acetate containing 5-nitro-1,3-dihydrobenzimidazol-2-one (1.4 g, 7.8 mmol) and the hydrogenation reaction was carried out for 6 hours. The progress of the reaction was monitored by thin layer chromatography (TLC, the unfolding agent was a chloroform solution of 10% methanol). After completion of the reaction, the reaction mixture was filtered through a bed of diatomaceous earth and the filtrate was concentrated to give the target product 5-amino-1,3-dihydrobenzimidazol-2-one (1 g, 86% yield).

References

[1] Patent: WO2012/59932, 2012, A1. Location in patent: Page/Page column 161-162
[2] Patent: WO2009/42907, 2009, A1. Location in patent: Page/Page column 78-79
[3] Journal of the American Chemical Society, 1958, vol. 80, p. 1662
[4] Patent: WO2012/115479, 2012, A2. Location in patent: Page/Page column 23
[5] Patent: CN104151251, 2017, B. Location in patent: Paragraph 0024

5-Amino-1,3-dihydro-2H-benzimidazol-2-one Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Amino-1,3-dihydro-2H-benzimidazol-2-one Suppliers

Americas 1 China 183 Czech Republic 1 Europe 2 France 1 Germany 4 India 9 Japan 1 Russia 2 Slovakia 1 Switzerland 1 Ukraine 3 United Kingdom 10 United States 27 Global 246

Wuhan Yuqing Jiaheng Pharmaceutical Co., Ltd.

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View Lastest Price from 5-Amino-1,3-dihydro-2H-benzimidazol-2-one manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 5-Amino-1,3-dihydro-2H-benzimidazol-2-one 95-23-8
Price: US $3.00-9.00/KG
Min. Order: 0.1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2025-06-27

Hebei Chuanghai Biotechnology Co,.LTD

Product: 5-Amino-1,3-dihydro-2H-benzimidazol-2-one 95-23-8
Price: US $30.00-10.00/kg
Min. Order: 10kg
Purity: 99%
Supply Ability: 100000kg
Release date: 2024-08-20

Zhuozhou Wenxi import and Export Co., Ltd

Product: 5-Amino-1,3-dihydro-2H-benzimidazol-2-one 95-23-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

95-23-8, 5-Amino-1,3-dihydro-2H-benzimidazol-2-oneRelated Search:

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5-Aminobenzimidazolone,98%

5-AMino-2-enziMidazolinone

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5-amino-1,3-dihydro-2h-benzimidazol-2-on

5-Amino-2-benzimidazolinone &gt

5-Amino-1,3-dihydro-2H-benzimidazol-2-one ISO 9001：2015 REACH

5-Amino-1,3-dihydro-2<i>H</i>-benzimidazol-2-one

Ilaprazole Impurity 170

95-23-8

C7H5N3O

Imidazol&Benzimidazole

Miscellaneous

Benzimidazole Series

BENZIMIDAZOLE

Intermediates of Dyes and Pigments