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Phenformin

Product Name
Phenformin
CAS No.
114-86-3
Chemical Name
Phenformin
Synonyms
pbi;phenethylbiguanide;Phenformine;PHENFORMIN HCL;N-Phenethylbiguanide;w32;Pedg;W 32;Dipar;dbcomb
CBNumber
CB6700560
Molecular Formula
C10H15N5
Formula Weight
205.26
MOL File
114-86-3.mol
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Phenformin Property

Melting point:
176.5 °C
Boiling point:
333.94°C (rough estimate)
Density 
1.0541 (rough estimate)
refractive index 
1.6380 (estimate)
pka
pKa 3.1/12.9±0.01(H2O,t =25,I>0.1) (Uncertain)
CAS DataBase Reference
114-86-3(CAS DataBase Reference)
NIST Chemistry Reference
Imidodicarbonimidic diamide, n-(2-phenylethyl)-(114-86-3)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
36
WGK Germany 
3
RTECS 
DU2200000
HS Code 
2925290090
Hazardous Substances Data
114-86-3(Hazardous Substances Data)
Toxicity
LD50 orl-rat: 1650 mg/kg BCFAAI 110,470,71
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
P296055
Product name
N-Phenethylbiguanide
Packaging
100mg
Price
$50
Updated
2021/12/16
Usbiological
Product number
288461
Product name
Phenformin
Packaging
250g
Price
$382
Updated
2021/12/16
AK Scientific
Product number
M819
Product name
Phenformin
Packaging
1g
Price
$154
Updated
2021/12/16
Apolloscientific
Product number
OR471153
Product name
N-Phenethylbiguanide
Packaging
5g
Price
$350
Updated
2021/12/16
SynQuest Laboratories
Product number
3641-1-04
Product name
N-Phenethylbiguanide
Packaging
5G
Price
$415
Updated
2021/12/16
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Phenformin Chemical Properties,Usage,Production

Originator

DBI ,Geigy, US ,1959

Uses

N-Phenethylbiguanide is used in cancer treatment methods using thermotherapy and/or enhanced immunotherapy.

Definition

ChEBI: A member of the class of biguanides that is biguanide in which one of the terminal nitrogen atoms is substituted by a 2-phenylethyl group. It was used as an anti-diabetic drug but was later withdrawn from the market due to potential risk of lactic acidos s.

Manufacturing Process

15.76 g of β-phenylethylamine hydrochloride and 8.4 g of dicyandiamide were ground and intimately mixed. The mixture was heated in an oil bath in a 3neck flask fitted with a thermometer and stirrer, and the mixture began to melt at a bath temperature of 125°C and was completely fluid at 130°C. Further heating at 145°C to 150°C initiated an exothermic reaction and the temperature of the fusion mixture (156°C) exceeded the oil bath temperature (150°C) by 6°. Heating was continued for one hour at bath temperature of 148°C to 150°C. The reaction mixture was cooled, dissolved in about 100 cc of methanol and filtered. The methanol filtrate was concentrated under reduced pressure, cooled and the product (β-phenylethylbiguanide hydrochloride) filtered off and recrystallized from 95% isopropanol.

brand name

DBI (Ciba-Geigy);Adibetin;Antipond;Bi-uglucon ud87;D bretard;Daopar;Db comb.;Db retard;De be;Debej;Diaformin;Dibein retard;Dibenide;Dibinyl;Dibolin;Dibophen;Dibun;Diebin retard;Diguabet;Dobeom;Fenguanide;Gluciferne;Glucifrene;Glucopstin;Kataglicina;Ls 6030;Oraleo;Prontoformin;Tolbrtaphen.

Therapeutic Function

Antidiabetic

World Health Organization (WHO)

Phenformin, a biguanide with oral hypoglycaemic activity, was introduced in 1957 for the management of diabetes mellitus. By 1970 its use had been associated with incidences of lactic acidosis and by 1976 clinical studies had conclusively demonstrated that the hazards of phenformin treatment outweighed the benefits. Preparations containing phenformin were withdrawn in several countries and their use restricted in others. Elsewhere, however, proprietary preparations containing this drug may remain available. The related biguanide, buformin, has been also associated with lactic acidosis and has been subjected to similar restrictions as phenformin, whereas there is some evidence that metformin is less liable to induce lactic acidosis. (Reference: (WHODI) WHO Drug Information, 2, 4, 1977)

Safety Profile

Poison by intraperitoneal, subcutaneous, and intravenous routes. Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of NOx.

Enzyme inhibitor

This oral, biguanide-class antidiabetic (FWhydrochloride = 241.72 g/mol; M.P. = 175-178°C; typically supplied as the water-soluble hydrochloride salt), also known as phenethylbiguanide and phenylethylbiguanide, and named systematically as N’-b-phenethylformamidinyliminourea, was withdrawn from the U.S. market in 1977 due to high risk of inducing often fatal lactic acidosis. Target(s): cholesterol biosynthesis; 7-dehydrocholesterol reductase; diamine oxidase; glucose transport; insulysin; pyruvate kinase; and ubiquinol:cytochrome c reductase. Phenformin is an activator of AMP-stimulated protein kinase, and like ther AMPK activators also induce nucleoli re-organization, with attendanty changes in cell proliferation. Among the compounds tested, phenformin and resveratrol had the most pronounced impact on nucleolar organization. 1. McDonald & Dalidowicz Biochemistry

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Phenformin Suppliers

Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11655
Advantage
64
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768850
Email
1791901229@qq.com
Country
China
ProdList
8844
Advantage
52
BioBioPha Co., Ltd.
Tel
0871-65217109 13211707573;
Fax
0871-65215563
Email
y.liu@mail.biobiopha.com
Country
China
ProdList
5653
Advantage
65
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
Shenzhen Shijingu Technology Co., Ltd
Tel
(0086)755-61930359 (0086)18038192047
Fax
(0086)755-84556470
Email
jo@pharmade.com
Country
China
ProdList
279
Advantage
58
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939 15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
16166
Advantage
55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 18112977050
Email
cb6@aikonchem.com
Country
China
ProdList
16684
Advantage
50
Hubei Jusheng Technology Co.,Ltd
Tel
027-59599241 18871490274
Fax
027-59599241
Email
1400878000@qq.com
Country
China
ProdList
9958
Advantage
58
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
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View Lastest Price from Phenformin manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
Phenformin 114-86-3
Price
US $999.00-666.00/g
Min. Order
1g
Purity
99%
Supply Ability
5000
Release date
2024-08-09
Hebei Chuanghai Biotechnology Co,.LTD
Product
Phenformin 114-86-3
Price
US $10.50/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 ton
Release date
2024-08-21
Zhejiang J&C Biological Technology Co.,Limited
Product
phenformin 114-86-3
Price
US $0.00/gram
Min. Order
1gram
Purity
99%
Supply Ability
10kg
Release date
2022-02-17

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