N,N,N',N'-Tetramethylazodicarboxamide

Description References

Product Name: N,N,N',N'-Tetramethylazodicarboxamide
CAS No.: 10465-78-8
Chemical Name: N,N,N',N'-Tetramethylazodicarboxamide
Synonyms: TMAD;DIAMIDE;Tetramethylazodicarboxamide;N1,N1,N2,N2-Tetramethyldiazene-1,2-dicarboxamide;(3E)-3-(dimethylcarbamoylimino)-1,1-dimethyl-urea;(E)-1-[(dimethylcarbamoyl)imino]-3,3-dimethylurea;Nsc143013;Diamide ,98%;Diamide, 10 mM in DMSO;Diamide, 98%, for synthesis
CBNumber: CB3340747
Molecular Formula: C6H12N4O2
Formula Weight: 172.19
MOL File: 10465-78-8.mol

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N,N,N',N'-Tetramethylazodicarboxamide Property

Melting point:: 112 °C
Boiling point:: 220.4±23.0 °C(Predicted)
Density: 1.13±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: soluble in Methanol
form: crystalline
pka: -0?+-.0.70(Predicted)
color: yellow
Water Solubility: water: 19.60-21.00mg/mL, clear to slightly hazy, orange
BRN: 1910409
InChI: InChI=1S/C6H12N4O2/c1-9(2)5(11)7-8-6(12)10(3)4/h1-4H3/b8-7+
InChIKey: VLSDXINSOMDCBK-BQYQJAHWSA-N
SMILES: C(=O)(/N=N/C(=O)N(C)C)N(C)C
CAS DataBase Reference: 10465-78-8(CAS DataBase Reference)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
RTECS: LQ1041000
F: 4.10
HS Code: 29270000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D3648
Product name: Diamide
Packaging: 1g
Price: $147
Updated: 2025/07/31

Sigma-Aldrich

Product number: D3648
Product name: Diamide
Packaging: 5g
Price: $648
Updated: 2025/07/31

TCI Chemical

Product number: A1458
Product name: 1,1'-Azobis(N,N-dimethylformamide)
Purity: >97.0%(T)
Packaging: 1g
Price: $23
Updated: 2025/07/31

TCI Chemical

Product number: A1458
Product name: 1,1'-Azobis(N,N-dimethylformamide)
Purity: >97.0%(T)
Packaging: 5g
Price: $84
Updated: 2025/07/31

Matrix Scientific

Product number: 099594
Product name: N1,N1,N2,N2-Tetramethyldiazene-1,2-dicarboxamide
Purity: 95+%
Packaging: 5g
Price: $504
Updated: 2021/12/16

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N,N,N',N'-Tetramethylazodicarboxamide Chemical Properties,Usage,Production

Description

N,N,N’,N’-Tetramethylazodicarboxamide (also named as Diamide, TMAD) is a reagent used for the oxidization of thiols in proteins. It is used as a reagent in the Mitsunobu reaction in place of diethyl azodicarboxylate. It can be used to titrate protein gluotathiolation to discriminate from other protein modifications.

References

N. S. Kosower, E. M. Kosower, Diamide: A oxidant probe for this, Methods in Enzymology, 1995, vol. 251, pp. 123133

Chemical Properties

Yellow crystals

Uses

Reported to be of use as a thiol oxidizing agent. Diamide has been used to titrate protein glutathiolation to discriminate from other oxidative protein modifications. Treatment increased protein glutathiolation in a concentration-dependent manner and had comparably little effect on protein-protein disulfide formation.

Definition

ChEBI: 1,1'-azobis(N,N-dimethylformamide) is a monoazo compound.

Synthesis Reference(s)

The Journal of Organic Chemistry, 38, p. 1652, 1973 DOI: 10.1021/jo00949a007

N,N,N',N'-Tetramethylazodicarboxamide Preparation Products And Raw materials

Raw materials

Silver oxide Triethylamine Dimethylcarbamoyl chloride Dichloromethane HYDRAZINE

Preparation Products

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N,N,N',N'-Tetramethylazodicarboxamide Suppliers

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View Lastest Price from N,N,N',N'-Tetramethylazodicarboxamide manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: N,N,N',N'-Tetramethylazodicarboxamide 10465-78-8
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-03-31

Career Henan Chemical Co

Product: N,N,N',N'-Tetramethylazodicarboxamide 10465-78-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1ton
Release date: 2018-08-06

10465-78-8, N,N,N',N'-TetramethylazodicarboxamideRelated Search:

Di-tert-Butyl azodicarboxylate N,N-Dimethylformamide Polyacrylamide Metformin PHTHALAMIDE 1,1'-(Azodicarbonyl)-dipiperidine Azodicarbonamide Pentamethyldiethylenetriamine Diethyl azodicarboxylate Dibenzyl azodicarboxylate Diisopropyl azodicarboxylate 1,8-Bis(dimethylamino)naphthalene N,N,N',N'-Tetraphenylbenzidine N,N,N',N'-TETRAMETHYLDIAMINOMETHANE AZODICARBOXYLIC BISMORPHOLIDE 1,1-DIMETHYLUREA Formamide N,N,N',N'-Tetramethylazodicarboxamide

AZODICARBOXYLIC ACID BIS[DIMETHYLAMIDE]

DIAMIDE

DIAZINE-DICARBOXYLIC ACID BIS[N,N-DIMETHYLAMIDE]

1,1'-AZOBIS(N,N'-DIMETHYLFORMAMIDE)

1,1'-AZOBIS(N,N-DIMETHYLFORMAMIDE)

N,N,N',N'-TETRAMETHYLAZODICARBAMIDE

1,1’-azobis(n,n-dimethyl-formamid

n,n,n’,n’-tetramethylazoformamide

Diamide N,N,N',N'-Tetramethylazodicarboxamide

Azodicarboxylic acid bis(dimethylamide), diamide

N1,N1,N2,N2-Tetramethyldiazene-1,2-dicarboxamide

TMAD N,N,N',N'-tetramethylazodicarboxamide

1,1'-Azobis(N,N-dimethylformamide)≥ 98%(Titration)

N,N,N',N'-Tetramethylazobisformamide

Nsc143013

N,N,N',N'-Tetramethylazodicarboxamide(TMAD)

Diamide ,98%

1-[(diMethylcarbaMoyl)iMino]-3,3-diMethylurea

tetramethyl-diazenedicarboxamid

tetramethyldiazenedicarboxamide

1,1-Azobis(N,N-dimethylforamide)

3-(N,N-dimethylcarbamoylimido)-1,1-dimethylurea

Diamide 1,1-Azobis(N,N-dimethylformamide)

blowing (and foaming) agent AC

Tetramethylazodicarboxamide

3-(Dimethylcarbamoylimino)-1,1-dimethylurea

Diazenedicarboxamide, tetramethyl-

Azobis(N,N-dimethylformamide)

N,N,N',N'-Tetramethyldiazene-1,2-dicarboxamide

N,N,N',N'-Tetramethyldiazenedicarboxamide

TMAD

1,1'-Azobis(N,N-dimethylformamide),98%

Tetramethylazodicarboxamide(TMAD)

(3E)-3-(dimethylcarbamoylimino)-1,1-dimethyl-urea

1,1μ-Azobis(N,N-dimethylformamide), Azodicarboxylic acid bis(dimethylamide), Diazinedicarboxylic acid bis(N,N-dimethylamide), N,N,Nμ,Nμ-Tetramethylazodicarboxamide

Azodicarboxylic acid bis(dimethylamide), diamide, Diamide, Diazinedicarboxylic acid bis(N,N-dimethylamide), N,N,Nμ,Nμ-Tetramethylazodicarboxamide

1,1′-Azobis(N,N-dimethylformamide), Azodicarboxylic acid bis(dimethylamide)

Diazenedicarboxylic acid bis(N,N-dimethylamide)

Formamide, 1,1'-azobis[N,N-dimethyl-

1,1'-Azobis(N,N-dimethylformamide) &gt

Diamide, 98%, for synthesis

1,2-Diazenedicarboxamide, N1,N1,N2,N2-tetramethyl-

N,N,N',N'-Tetramethylazodicarboxamide ISO 9001：2015 REACH

(E)-1-[(dimethylcarbamoyl)imino]-3,3-dimethylurea

TIANFU-CHEM CAS:10465-78-8 N,N,N',N'-Tetramethylazodicarboxamide

(E)-N1,N1,N2,N2-tetramethyldiazene-1,2-dicarboxamide

N,N,N',N'-Tetramethylazodicarboxamide

TMADN,N,N',N'-tetramethylazodicarboxamide

N,N,N’,N’-Tetramethylazodicarboxamide(TMAD)

Diamide, 10 mM in DMSO

N1,N1,N2,N2-Tetramethyl-1,2-diazenedicarboxamide - [D71729]

N,N,N',N'-Tetramethylazodicarboxamide

10465-78-8

CH32NCONNCONCH32

Amides

BioChemical

Building Blocks

Biochemicals and Reagents