N,N,N',N'-Tetramethylazodicarboxamide
Description References- Product Name
- N,N,N',N'-Tetramethylazodicarboxamide
- CAS No.
- 10465-78-8
- Chemical Name
- N,N,N',N'-Tetramethylazodicarboxamide
- Synonyms
- TMAD;DIAMIDE;Tetramethylazodicarboxamide;N1,N1,N2,N2-Tetramethyldiazene-1,2-dicarboxamide;(3E)-3-(dimethylcarbamoylimino)-1,1-dimethyl-urea;(E)-1-[(dimethylcarbamoyl)imino]-3,3-dimethylurea;Nsc143013;Diamide ,98%;Diamide, 98%, for synthesis;Azobis(N,N-dimethylformamide)
- CBNumber
- CB3340747
- Molecular Formula
- C6H12N4O2
- Formula Weight
- 172.19
- MOL File
- 10465-78-8.mol
N,N,N',N'-Tetramethylazodicarboxamide Property
- Melting point:
- 112 °C
- Boiling point:
- 220.4±23.0 °C(Predicted)
- Density
- 1.13±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- soluble in Methanol
- form
- crystalline
- pka
- -0?+-.0.70(Predicted)
- color
- yellow
- BRN
- 1910409
- InChI
- InChI=1S/C6H12N4O2/c1-9(2)5(11)7-8-6(12)10(3)4/h1-4H3/b8-7+
- InChIKey
- VLSDXINSOMDCBK-BQYQJAHWSA-N
- SMILES
- C(=O)(/N=N/C(=O)N(C)C)N(C)C
- CAS DataBase Reference
- 10465-78-8(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
N-Bromosuccinimide Price
- Product number
- D3648
- Product name
- Diamide
- Packaging
- 1g
- Price
- $143
- Updated
- 2024/03/01
- Product number
- D3648
- Product name
- Diamide
- Packaging
- 5g
- Price
- $629
- Updated
- 2024/03/01
- Product number
- A1458
- Product name
- 1,1'-Azobis(N,N-dimethylformamide)
- Purity
- >97.0%(T)
- Packaging
- 1g
- Price
- $23
- Updated
- 2024/03/01
- Product number
- A1458
- Product name
- 1,1'-Azobis(N,N-dimethylformamide)
- Purity
- >97.0%(T)
- Packaging
- 5g
- Price
- $84
- Updated
- 2024/03/01
- Product number
- J64865
- Product name
- 1,1'-Azobis(N,N-dimethylformamide), 95%
- Packaging
- 1g
- Price
- $140
- Updated
- 2024/03/01
N,N,N',N'-Tetramethylazodicarboxamide Chemical Properties,Usage,Production
Description
N,N,N’,N’-Tetramethylazodicarboxamide (also named as Diamide, TMAD) is a reagent used for the oxidization of thiols in proteins. It is used as a reagent in the Mitsunobu reaction in place of diethyl azodicarboxylate. It can be used to titrate protein gluotathiolation to discriminate from other protein modifications.
References
N. S. Kosower, E. M. Kosower, Diamide: A oxidant probe for this, Methods in Enzymology, 1995, vol. 251, pp. 123133
Chemical Properties
Yellow crystals
Uses
Reported to be of use as a thiol oxidizing agent. Diamide has been used to titrate protein glutathiolation to discriminate from other oxidative protein modifications. Treatment increased protein glutathiolation in a concentration-dependent manner and had comparably little effect on protein-protein disulfide formation.
Definition
ChEBI: 1,1'-azobis(N,N-dimethylformamide) is a monoazo compound.
Synthesis Reference(s)
The Journal of Organic Chemistry, 38, p. 1652, 1973 DOI: 10.1021/jo00949a007
N,N,N',N'-Tetramethylazodicarboxamide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from N,N,N',N'-Tetramethylazodicarboxamide manufacturers
- Product
- N,N,N',N'-Tetramethylazodicarboxamide 10465-78-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1ton
- Release date
- 2018-08-06