Description References
ChemicalBook > CAS DataBase List > N,N,N',N'-Tetramethylazodicarboxamide

N,N,N',N'-Tetramethylazodicarboxamide

Description References
Product Name
N,N,N',N'-Tetramethylazodicarboxamide
CAS No.
10465-78-8
Chemical Name
N,N,N',N'-Tetramethylazodicarboxamide
Synonyms
TMAD;DIAMIDE;Tetramethylazodicarboxamide;N1,N1,N2,N2-Tetramethyldiazene-1,2-dicarboxamide;(3E)-3-(dimethylcarbamoylimino)-1,1-dimethyl-urea;(E)-1-[(dimethylcarbamoyl)imino]-3,3-dimethylurea;Nsc143013;Diamide ,98%;Diamide, 98%, for synthesis;Azobis(N,N-dimethylformamide)
CBNumber
CB3340747
Molecular Formula
C6H12N4O2
Formula Weight
172.19
MOL File
10465-78-8.mol
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N,N,N',N'-Tetramethylazodicarboxamide Property

Melting point:
112 °C
Boiling point:
220.4±23.0 °C(Predicted)
Density 
1.13±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
soluble in Methanol
form 
crystalline
pka
-0?+-.0.70(Predicted)
color 
yellow
BRN 
1910409
InChI
InChI=1S/C6H12N4O2/c1-9(2)5(11)7-8-6(12)10(3)4/h1-4H3/b8-7+
InChIKey
VLSDXINSOMDCBK-BQYQJAHWSA-N
SMILES
C(=O)(/N=N/C(=O)N(C)C)N(C)C
CAS DataBase Reference
10465-78-8(CAS DataBase Reference)
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
RTECS 
LQ1041000
F 
4.10
HS Code 
29270000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D3648
Product name
Diamide
Packaging
1g
Price
$143
Updated
2024/03/01
Sigma-Aldrich
Product number
D3648
Product name
Diamide
Packaging
5g
Price
$629
Updated
2024/03/01
TCI Chemical
Product number
A1458
Product name
1,1'-Azobis(N,N-dimethylformamide)
Purity
>97.0%(T)
Packaging
1g
Price
$23
Updated
2024/03/01
TCI Chemical
Product number
A1458
Product name
1,1'-Azobis(N,N-dimethylformamide)
Purity
>97.0%(T)
Packaging
5g
Price
$84
Updated
2024/03/01
Alfa Aesar
Product number
J64865
Product name
1,1'-Azobis(N,N-dimethylformamide), 95%
Packaging
1g
Price
$140
Updated
2024/03/01
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N,N,N',N'-Tetramethylazodicarboxamide Chemical Properties,Usage,Production

Description

N,N,N’,N’-Tetramethylazodicarboxamide (also named as Diamide, TMAD) is a reagent used for the oxidization of thiols in proteins. It is used as a reagent in the Mitsunobu reaction in place of diethyl azodicarboxylate. It can be used to titrate protein gluotathiolation to discriminate from other protein modifications.

References

N. S. Kosower, E. M. Kosower, Diamide: A oxidant probe for this, Methods in Enzymology, 1995, vol. 251, pp. 123133

Chemical Properties

Yellow crystals

Uses

Reported to be of use as a thiol oxidizing agent. Diamide has been used to titrate protein glutathiolation to discriminate from other oxidative protein modifications. Treatment increased protein glutathiolation in a concentration-dependent manner and had comparably little effect on protein-protein disulfide formation.

Definition

ChEBI: 1,1'-azobis(N,N-dimethylformamide) is a monoazo compound.

Synthesis Reference(s)

The Journal of Organic Chemistry, 38, p. 1652, 1973 DOI: 10.1021/jo00949a007

N,N,N',N'-Tetramethylazodicarboxamide Preparation Products And Raw materials

Raw materials

Silver oxide Triethylamine Dimethylcarbamoyl chloride Dichloromethane HYDRAZINE

Preparation Products

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N,N,N',N'-Tetramethylazodicarboxamide Suppliers

Americas 1 China 146 Czech Republic 1 Europe 3 Germany 3 India 5 Japan 2 Switzerland 1 United Kingdom 8 United States 28 Global 198
SIGMA-RBI
Tel
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Fax
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Country
Switzerland
ProdList
6896
Advantage
91
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View Lastest Price from N,N,N',N'-Tetramethylazodicarboxamide manufacturers

Career Henan Chemical Co
Product
N,N,N',N'-Tetramethylazodicarboxamide 10465-78-8
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1ton
Release date
2018-08-06

10465-78-8, N,N,N',N'-TetramethylazodicarboxamideRelated Search:

Di-tert-Butyl azodicarboxylate N,N-Dimethylformamide Polyacrylamide Metformin PHTHALAMIDE 1,1'-(Azodicarbonyl)-dipiperidine Azodicarbonamide Pentamethyldiethylenetriamine Diethyl azodicarboxylate Dibenzyl azodicarboxylate Diisopropyl azodicarboxylate 1,8-Bis(dimethylamino)naphthalene N,N,N',N'-Tetraphenylbenzidine N,N,N',N'-TETRAMETHYLDIAMINOMETHANE AZODICARBOXYLIC BISMORPHOLIDE 1,1-DIMETHYLUREA Formamide N,N,N',N'-Tetramethylazodicarboxamide

  • AZODICARBOXYLIC ACID BIS[DIMETHYLAMIDE]
  • DIAMIDE
  • DIAZINE-DICARBOXYLIC ACID BIS[N,N-DIMETHYLAMIDE]
  • 1,1'-AZOBIS(N,N'-DIMETHYLFORMAMIDE)
  • 1,1'-AZOBIS(N,N-DIMETHYLFORMAMIDE)
  • N,N,N',N'-TETRAMETHYLAZODICARBAMIDE
  • N,N,N',N'-TETRAMETHYLAZODICARBOXAMIDE
  • 1,1’-azobis(n,n-dimethyl-formamid
  • n,n,n’,n’-tetramethylazoformamide
  • Diamide N,N,N',N'-Tetramethylazodicarboxamide
  • Azodicarboxylic acid bis(dimethylamide), diamide
  • N1,N1,N2,N2-Tetramethyldiazene-1,2-dicarboxamide
  • TMAD N,N,N',N'-tetramethylazodicarboxamide
  • 1,1'-Azobis(N,N-dimethylformamide)≥ 98%(Titration)
  • N,N,N',N'-Tetramethylazobisformamide
  • Nsc143013
  • N,N,N',N'-Tetramethylazodicarboxamide(TMAD)
  • Diamide ,98%
  • 1-[(diMethylcarbaMoyl)iMino]-3,3-diMethylurea
  • tetramethyl-diazenedicarboxamid
  • tetramethyldiazenedicarboxamide
  • 1,1-Azobis(N,N-dimethylforamide)
  • 3-(N,N-dimethylcarbamoylimido)-1,1-dimethylurea
  • Diamide 1,1-Azobis(N,N-dimethylformamide)
  • blowing (and foaming) agent AC
  • Tetramethylazodicarboxamide
  • 3-(Dimethylcarbamoylimino)-1,1-dimethylurea
  • Diazenedicarboxamide, tetramethyl-
  • Azobis(N,N-dimethylformamide)
  • N,N,N',N'-Tetramethyldiazene-1,2-dicarboxamide
  • N,N,N',N'-Tetramethyldiazenedicarboxamide
  • TMAD
  • 1,1'-Azobis(N,N-dimethylformamide),98%
  • Tetramethylazodicarboxamide(TMAD)
  • (3E)-3-(dimethylcarbamoylimino)-1,1-dimethyl-urea
  • 1,1μ-Azobis(N,N-dimethylformamide), Azodicarboxylic acid bis(dimethylamide), Diazinedicarboxylic acid bis(N,N-dimethylamide), N,N,Nμ,Nμ-Tetramethylazodicarboxamide
  • Azodicarboxylic acid bis(dimethylamide), diamide, Diamide, Diazinedicarboxylic acid bis(N,N-dimethylamide), N,N,Nμ,Nμ-Tetramethylazodicarboxamide
  • 1,1′-Azobis(N,N-dimethylformamide), Azodicarboxylic acid bis(dimethylamide)
  • Diazenedicarboxylic acid bis(N,N-dimethylamide)
  • Formamide, 1,1'-azobis[N,N-dimethyl-
  • 1,1'-Azobis(N,N-dimethylformamide) &gt
  • Diamide, 98%, for synthesis
  • 1,2-Diazenedicarboxamide, N1,N1,N2,N2-tetramethyl-
  • N,N,N',N'-Tetramethylazodicarboxamide ISO 9001：2015 REACH
  • (E)-1-[(dimethylcarbamoyl)imino]-3,3-dimethylurea
  • TIANFU-CHEM CAS:10465-78-8 N,N,N',N'-Tetramethylazodicarboxamide
  • (E)-N1,N1,N2,N2-tetramethyldiazene-1,2-dicarboxamide
  • N,N,N',N'-Tetramethylazodicarboxamide
  • TMADN,N,N',N'-tetramethylazodicarboxamide
  • N,N,N’,N’-Tetramethylazodicarboxamide(TMAD)
  • 10465-78-8
  • CH32NCONNCONCH32
  • Amides
  • BioChemical
  • Building Blocks
  • Biochemicals and Reagents
  • Carbonyl Compounds
  • Glyceraldehyde 3-Phosphate Dehydrogenase from a green algae