1H-Benzimidazole-4-carboxylicacid,methylester(9CI)
- Product Name
- 1H-Benzimidazole-4-carboxylicacid,methylester(9CI)
- CAS No.
- 37619-25-3
- Chemical Name
- 1H-Benzimidazole-4-carboxylicacid,methylester(9CI)
- Synonyms
- Methyl 1H-benzo[d]iMidazole-4-carboxylate;Methyl 4-benzimidazolecarboxylate;Methyl Benzimidazole-4-carboxylate;Methyl 1,3-benzodiazole-4-carboxylate;Methyl 3H-benzimidazole-4-carboxylate;methyl 4(7)-benzimidazolylcarboxylate;Methyl-1H-benzimidazole-4-carboxylate;methyl 1H-1,3-benzodiazole-4-carboxylate;methyl 1H-benzo[d]imidazole-7-carboxylate;1H-benzo [D] imidazole-4-methyl carboxylate
- CBNumber
- CB51290863
- Molecular Formula
- C9H8N2O2
- Formula Weight
- 176.17
- MOL File
- 37619-25-3.mol
1H-Benzimidazole-4-carboxylicacid,methylester(9CI) Property
- Boiling point:
- 416.2±18.0 °C(Predicted)
- Density
- 1.324±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 10.78±0.30(Predicted)
- Appearance
- Light brown to black Solid
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M335225
- Product name
- Methyl1,3-Benzodiazole-4-carboxylate
- Packaging
- 500mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- 454684
- Product name
- Methyl 1,3-benzodiazole-4-carboxylate
- Packaging
- 25mg
- Price
- $305
- Updated
- 2021/12/16
- Product number
- CHM0098076
- Product name
- 1H-BENZIMIDAZOLE-4-CARBOXYLIC ACID METHYL ESTER
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.56
- Updated
- 2021/12/16
- Product number
- 131724
- Product name
- Methyl1H-benzo[d]imidazole-4-carboxylate
- Purity
- 97%
- Packaging
- 5g
- Price
- $1342
- Updated
- 2021/12/16
- Product number
- 131724
- Product name
- Methyl1H-benzo[d]imidazole-4-carboxylate
- Purity
- 97%
- Packaging
- 10g
- Price
- $2160
- Updated
- 2021/12/16
1H-Benzimidazole-4-carboxylicacid,methylester(9CI) Chemical Properties,Usage,Production
Synthesis
67-56-1
46006-36-4
37619-25-3
General procedure for the synthesis of methyl 1H-benzo[d]imidazole-4-carboxylate from methanol and benzimidazole-7-carboxylic acid: benzimidazole-7-carboxylic acid (1.136 g, 7.02 mmol) was dissolved in methanol (115 mL) and concentrated HCl and H2SO4 (0.86 mL, 15.45 mmol) were added. The reaction mixture was heated under reflux conditions until thin layer chromatography (TLC) showed that the reaction was complete (24-36 hours). Upon completion of the reaction, the mixture was concentrated to a few mL and the pH was adjusted to 8.5 with 1 M K3PO4 solution. the resulting precipitate was separated by filtration and dried under reduced pressure to afford methyl 1H-benzo[d]imidazole-4-carboxylate (0.940 g, 76% yield) as a white solid. The melting point was 211-213 °C (literature value 204 °C).1H NMR (300 MHz, DMSO-d6) δ 8.31 (s, 1H), 7.95 (dd, J = 8.0,0.9 Hz, 1H), 7.83 (dd, J = 7.6,0.9 Hz, 1H), 7.29 (dd, J = 8.0,7.6 Hz, 1H).13C NMR (75 MHz, DMSO-d6) δ 265.5,144.1,143.6,132.3,124.7,124.3,121.0,113.8.
References
[1] Australian Journal of Chemistry, 1993, vol. 46, # 8, p. 1177 - 1191
[2] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 14, p. 3933 - 3937
[3] Patent: WO2016/138335, 2016, A1. Location in patent: Paragraph 00366
1H-Benzimidazole-4-carboxylicacid,methylester(9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1H-Benzimidazole-4-carboxylicacid,methylester(9CI) manufacturers
- Product
- Methyl 1H-benzo[d]imidazole-4-carboxylate 37619-25-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-09