ChemicalBook > CAS DataBase List > 4-CHLORO-5-FLUORO-2-NITROPHENOL

4-CHLORO-5-FLUORO-2-NITROPHENOL

Product Name
4-CHLORO-5-FLUORO-2-NITROPHENOL
CAS No.
345-25-5
Chemical Name
4-CHLORO-5-FLUORO-2-NITROPHENOL
Synonyms
2-amino-4-chloro-5-fluorophenol;4-CHLORO-5-FLUORO-2-NITROPHENOL;2-Nitro-4-chloro-5-fluorophenol;Phenol, 4-chloro-5-fluoro-2-nitro-;5-Chloro-4-fluoro-2-hydroxyaniline;5-Chloro-4-fluoro-2-hydroxynitrobenzene;4-CHLORO-5-FLUORO-2-NITROPHENOL ISO 9001：2015 REACH
CBNumber
CB52465589
Molecular Formula
C6H3ClFNO3
Formula Weight
191.54
MOL File
345-25-5.mol
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4-CHLORO-5-FLUORO-2-NITROPHENOL Property

storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
fine crystalline powder
color 
Bright lemon/lime
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Safety

HS Code 
2908990000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
C994338
Product name
4-Chloro-5-fluoro-2-nitrophenol
Packaging
100mg
Price
$90
Updated
2021/12/16
TRC
Product number
C994338
Product name
4-Chloro-5-fluoro-2-nitrophenol
Packaging
50mg
Price
$45
Updated
2021/12/16
TRC
Product number
C994338
Product name
4-Chloro-5-fluoro-2-nitrophenol
Packaging
500mg
Price
$310
Updated
2021/12/16
Apolloscientific
Product number
PC10643
Product name
4-Chloro-5-fluoro-2-nitrophenol
Purity
98%
Packaging
5g
Price
$348
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC143797
Product name
4-Chloro-5-fluoro-2-nitrophenol
Packaging
2g
Price
$375
Updated
2021/12/16
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4-CHLORO-5-FLUORO-2-NITROPHENOL Chemical Properties,Usage,Production

Synthesis

348-60-7

345-25-5

General procedure for the synthesis of 4-chloro-5-fluoro-2-nitrophenol from 4-chloro-3-fluorophenol: 4-chloro-3-fluorophenol (2.38 g, 16.2 mmol) was dissolved in dichloroethane (DCE, 32 mL), followed by addition of tetrabutylammonium bromide (0.524 g, 1.62 mmol). A 7% nitric acid solution was prepared by diluting 70% nitric acid (HNO3, 2.1 mL, 32 mmol) with water (18.9 mL). This nitric acid solution was slowly added to the reaction mixture and the reaction was stirred at room temperature for 4 h. The progress of the reaction was monitored by thin layer chromatography (TLC) until the reaction was completed. After completion of the reaction, the reaction mixture was poured into water and extracted with dichloromethane (DCM, 3 × 30 mL). The organic layers were combined, dried with anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure. The obtained residue was adsorbed on silica gel and purified by fast column chromatography to afford the target product 4-chloro-5-fluoro-2-nitrophenol (2.29 g, 74% yield). The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 11.76 (br.s, 1H), 8.18 (d, J = 8.1 Hz, 1H), 7.10 (d, J = 10.6 Hz, 1H).

References

[1] Patent: US2008/300242, 2008, A1. Location in patent: Page/Page column 114
[2] Journal of the Chemical Society, 1949, p. 3437
[3] Patent: WO2011/151361, 2011, A1. Location in patent: Page/Page column 27

4-CHLORO-5-FLUORO-2-NITROPHENOL Preparation Products And Raw materials

Raw materials

Preparation Products

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4-CHLORO-5-FLUORO-2-NITROPHENOL Suppliers

China 43 India 1 United Kingdom 2 United States 6 Global 52
Beijing Eternalchem Co,. Ltd.
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Hangzhou Molcore Biopharmatech Co.,Ltd
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400-711-5280 86-571-81025280
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Aikon International Limited
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View Lastest Price from 4-CHLORO-5-FLUORO-2-NITROPHENOL manufacturers

Career Henan Chemical Co
Product
4-CHLORO-5-FLUORO-2-NITROPHENOL 345-25-5
Price
US $1.00/KG
Min. Order
1g
Purity
99.0%
Supply Ability
100kg
Release date
2020-01-10

345-25-5, 4-CHLORO-5-FLUORO-2-NITROPHENOLRelated Search:

2-amino-3-chlorophenol 5-Fluoro-2-nitrophenol

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  • 2-amino-4-chloro-5-fluorophenol
  • 5-Chloro-4-fluoro-2-hydroxynitrobenzene
  • 5-Chloro-4-fluoro-2-hydroxyaniline
  • 2-Nitro-4-chloro-5-fluorophenol
  • Phenol, 4-chloro-5-fluoro-2-nitro-
  • 4-CHLORO-5-FLUORO-2-NITROPHENOL ISO 9001：2015 REACH
  • 345-25-5