ChemicalBook > CAS DataBase List > 8-METHYLIMIDAZO[1,2-A]PYRIDINE

8-METHYLIMIDAZO[1,2-A]PYRIDINE

Product Name: 8-METHYLIMIDAZO[1,2-A]PYRIDINE
CAS No.: 874-10-2
Chemical Name: 8-METHYLIMIDAZO[1,2-A]PYRIDINE
Synonyms: 8-methyl-imidazolopyrimidine;8-METHYLIMIDAZO[1,2-A]PYRIDINE;Imidazo[1,2-a]pyridine, 8-methyl-
CBNumber: CB5246663
Molecular Formula: C8H8N2
Formula Weight: 132.16
MOL File: 874-10-2.mol

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8-METHYLIMIDAZO[1,2-A]PYRIDINE Property

Boiling point:: 69°C 0,1mm
Density: 1.11±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 7.33±0.50(Predicted)
Appearance: Brown to black Liquid

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Safety

Risk Statements: 43
Safety Statements: 36/37
HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Matrix Scientific

Product number: 045473
Product name: 8-Methylimidazo[1,2-a]pyridine
Purity: 95+%
Packaging: 500mg
Price: $97
Updated: 2021/12/16

Matrix Scientific

Product number: 045473
Product name: 8-Methylimidazo[1,2-a]pyridine
Purity: 95+%
Packaging: 1g
Price: $149
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-1-CH
Product name: 8-Methylimidazo[1,2-a]pyridine
Packaging: 1g
Price: $176
Updated: 2021/12/16

AK Scientific

Product number: 3834AC
Product name: 8-Methylimidazo[1,2-a]pyridine
Packaging: 1g
Price: $195
Updated: 2021/12/16

Matrix Scientific

Product number: 045473
Product name: 8-Methylimidazo[1,2-a]pyridine
Purity: 95+%
Packaging: 5g
Price: $445
Updated: 2021/12/16

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8-METHYLIMIDAZO[1,2-A]PYRIDINE Chemical Properties,Usage,Production

Synthesis

1603-40-3

2032-35-1

874-10-2

General procedure for the synthesis of 8-methyl-imidazo[1,2-A]pyridine from 2-amino-3-methylpyridine and 2-bromo-1,1-diethoxyethane: 2-amino-3-methylpyridine (10 g, 92.5 mmol) and 2-bromo-1,1-diethoxyethane (36.4 g, 185 mmol) were dissolved in ethanol (100 mL). Subsequently, 48% aqueous hydrogen bromide solution (9 mL) was slowly added dropwise to the reaction solution. The reaction system was heated to 90 °C and after 26 h of reaction, the completion of the reaction was confirmed by LC-MS and then cooled to room temperature. The reaction system was first distilled under reduced pressure to remove ethanol, followed by neutralization of excess hydrobromic acid in the reaction with excess saturated aqueous sodium bicarbonate solution (100 mL) and solid sodium bicarbonate (15 g). The remaining mixture was extracted with ethyl acetate (200 mL x 3). All organic phases were combined, washed sequentially with deionized water (100 mL) and saturated brine (100 mL) each, dried with anhydrous sodium sulfate, and the solvent was subsequently removed by rotary evaporation. Finally, the remaining mixture was purified by silica gel column chromatography (eluent: dichloromethane/methanol = 0-10%) to afford 8-methyl-imidazo[1,2-a]pyridine (12 g, 98% yield).

References

[1] Patent: CN106279160, 2017, A. Location in patent: Paragraph 0259; 0263; 0264; 0265
[2] Bulletin of the Chemical Society of Japan, 1999, vol. 72, # 6, p. 1327 - 1334

8-METHYLIMIDAZO[1,2-A]PYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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874-10-2, 8-METHYLIMIDAZO[1,2-A]PYRIDINERelated Search:

8-METHYL-IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER Imidazo[1,2-a]pyridine-2-carboxaldehyde, 8-methyl- (9CI) 8-METHYL-IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID 2-AMINO-6-METHYLDIPYRIDO[1,2-A:3',2'-D]IMIDAZOLE, HYDROCHLORIDE MONOHYDRATE Ethyl 2-methylimidazo[1,2-a]pyridine-3-carboxylate ,97% 3-nitro-5-methylimidazo[1,2-a]pyridine 2-Methylimidazo[1,2-a]pyridine-3-carboxylic acid ,97% (2,8-DIMETHYL-IMIDAZO[1,2-A]PYRIDIN-3-YL)-METHANOL 2,7-DIMETHYLPYRIDO[1,6-A]-1H-IMIDAZOLE-3-CARBOXYLIC ACID, ETHYL ESTER 2-Chloromethyl-8-methyl-imidazo[1,2-a]pyridine 7-METHYL-2-PHENYLIMIDAZO[1,2-A]PYRIDINE-3-CARBOXYLIC ACID ETHYL 8-METHYL-2-PHENYLIMIDAZO[1,2-A]PYRIDINE-3-CARBOXYLATE 2-(4-FLUOROPHENYL)-8-METHYLIMIDAZO[1,2-A]PYRIDINE 2-(2-methoxyphenyl)-7-methylimidazo[1,2-a]pyridine-3-carbaldehyde 2-(2,5-DIMETHYLPHENYL)-8-METHYLIMIDAZO[1,2-A]PYRIDINE-3-CARBALDEHYDE 2-(2-methoxyphenyl)-8-methylimidazo[1,2-a]pyridine-3-carbaldehyde 2-(4-ethylphenyl)-6-methylimidazo[1,2-a]pyridine-3-carbaldehyde 2-(2,5-dimethylphenyl)-7-methylimidazo[1,2-a]pyridine-3-carbaldehyde

8-METHYLIMIDAZO[1,2-A]PYRIDINE

Imidazo[1,2-a]pyridine, 8-methyl-

8-methyl-imidazolopyrimidine

874-10-2