METHYL 3-OXOHEPTANOATE
- Product Name
- METHYL 3-OXOHEPTANOATE
- CAS No.
- 39815-78-6
- Chemical Name
- METHYL 3-OXOHEPTANOATE
- Synonyms
- VEM;Valeric METHYL 3-OXOENANTHATE;METHYL VALERYLACETATE;METHYL 3-OXOHEPTANOATE;Methyl3-Oxoheptanoate>Methyl valerylacetate, VEM;3-OXOENANTHIC ACID METHYL ESTER;3-OXOHEPTANOIC ACID METHYL ESTER;3-Ketoenanthic acid methyl ester
- CBNumber
- CB5246810
- Molecular Formula
- C8H14O3
- Formula Weight
- 158.2
- MOL File
- 39815-78-6.mol
METHYL 3-OXOHEPTANOATE Property
- Boiling point:
- 90-91 °C15 hPa(lit.)
- Density
- 0.994 g/mL at 20 °C(lit.)
- refractive index
- 1.4280-1.4310
- Flash point:
- 95 °C
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Oil
- pka
- 10.63±0.46(Predicted)
- color
- Clear Colorless
- InChIKey
- CZTKGERSDUGZPQ-UHFFFAOYSA-N
Safety
- Safety Statements
- 24/25
- WGK Germany
- -
- HS Code
- 29159000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- O0246
- Product name
- Methyl 3-Oxoheptanoate
- Purity
- >95.0%(GC)
- Packaging
- 25mL
- Price
- $95
- Updated
- 2025/07/31
- Product number
- M324730
- Product name
- Methyl 3-Oxoheptanoate
- Packaging
- 5g
- Price
- $110
- Updated
- 2021/12/16
- Product number
- M324730
- Product name
- Methyl 3-Oxoheptanoate
- Packaging
- 100g
- Price
- $525
- Updated
- 2021/12/16
- Product number
- 39055
- Product name
- Methyl3-oxoheptanoate,≥95%(GC)
- Purity
- ≥95%(GC)
- Packaging
- 25ML
- Price
- $163.07
- Updated
- 2021/12/16
- Product number
- 5240AB
- Product name
- Methyl 3-Oxoheptanoate
- Packaging
- 25mL
- Price
- $234
- Updated
- 2021/12/16
METHYL 3-OXOHEPTANOATE Chemical Properties,Usage,Production
Chemical Properties
Colorless to pale yellow transparent liquid
Uses
Methyl 3-oxoheptanoate is used as a reagent to synthesize 4-oxymethyl-1,2-dioxanes, compounds that exhibit potent anti-malarial activity. Methyl 3-oxoheptanoate is also used as a reagent to prepare a series of substituted cyclopenta-[d]-pyrimidines, compounds that act as anti-microtubule (anticancer) agents.
Synthesis
7732-18-5
107-08-4
105-45-3
39815-78-6
To a 200 mL solution of anhydrous tetrahydrofuran (THF) containing 14 mL of diisopropylamine was slowly added 59 mL of a 1.6 M butyllithium hexane solution under nitrogen protection and stirred for 20 minutes. Subsequently, 9.3 mL of methyl acetoacetate was added dropwise at 0°C and stirring was continued for 30 minutes. Another 54 mL of hexane solution of 1.6 M butyllithium was added slowly and stirred for 30 minutes before 8.4 mL of 1-iodopropane was added dropwise to the dark orange solution. The reaction mixture was gradually warmed to room temperature and stirring was continued for 30 minutes. A solution diluted by 50 mL of 37% hydrochloric acid and 100 mL of water was added slowly and dropwise while keeping the temperature below 15 °C. Upon completion of the reaction, the reaction mixture was extracted with ether (Et2O). The organic phase was washed with saturated sodium chloride (NaCl) solution, dried over anhydrous sodium sulfate (Na2SO4) and concentrated to dryness under reduced pressure. The residue was purified by column chromatography (eluent: ethyl acetate/hexane=1:9) to afford 8.3 g of the clear oily product methyl 3-oxoheptanoate in 61% yield.1H-NMR (200 MHz, CDCl3) δ: 0.90 (t, 3H), 1.22-1.65 (m, 4H), 2.53 (t, 2H), 3.44 (s, 2H), 3.73 (s, 3H).
References
[1] Patent: US5565464, 1996, A
METHYL 3-OXOHEPTANOATE Preparation Products And Raw materials
Raw materials
Preparation Products
METHYL 3-OXOHEPTANOATE Suppliers
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View Lastest Price from METHYL 3-OXOHEPTANOATE manufacturers
- Product
- METHYL 3-OXOHEPTANOATE 39815-78-6
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2025-03-14
- Product
- Methyl 3-Oxoheptanoate 39815-78-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98% HPLC
- Supply Ability
- 10 tons
- Release date
- 2020-02-14