1-(2-Chloro-6-hydroxyphenyl)ethanone

Product Name: 1-(2-Chloro-6-hydroxyphenyl)ethanone
CAS No.: 55736-04-4
Chemical Name: 1-(2-Chloro-6-hydroxyphenyl)ethanone
Synonyms: oro-6-hydroxyphenyL;1-(2-Chloro-6-hydroxyphenyl);2’-Chloro-6’-hydroxyacetophenone;2'-Chloro-6'-hydroxyacetophenone;1-(2-Chloro-6-hydroxyphenyl)ethanone;Ethanone, 1-(2-chloro-6-hydroxyphenyl)-;1-(2-Chloro-6-hydroxyphenyl)ethan-1-one 97+%
CBNumber: CB52470017
Molecular Formula: C8H7ClO2
Formula Weight: 170.59
MOL File: 55736-04-4.mol

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1-(2-Chloro-6-hydroxyphenyl)ethanone Property

Boiling point:: 225.4±20.0 °C(Predicted)
Density: 1.298±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 9.20±0.10(Predicted)
Appearance: Off-white to yellow Solid
InChI: InChI=1S/C8H7ClO2/c1-5(10)8-6(9)3-2-4-7(8)11/h2-4,11H,1H3
InChIKey: RUSSVKYJPIADHS-UHFFFAOYSA-N
SMILES: C(=O)(C1=C(O)C=CC=C1Cl)C

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Safety

HS Code: 2914500090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C585620
Product name: 1-(2-Chloro-6-hydroxyphenyl)ethanone
Packaging: 50mg
Price: $45
Updated: 2021/12/16

TRC

Product number: C585620
Product name: 1-(2-Chloro-6-hydroxyphenyl)ethanone
Packaging: 100mg
Price: $75
Updated: 2021/12/16

TRC

Product number: C585620
Product name: 1-(2-Chloro-6-hydroxyphenyl)ethanone
Packaging: 500mg
Price: $165
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC153387
Product name: 1-?(2-?Chloro-6-hydroxyphenyl)ethanone
Packaging: 100mg
Price: $220
Updated: 2021/12/16

AK Scientific

Product number: J94265
Product name: 1-(2-Chloro-6-hydroxyphenyl)ethanone
Packaging: 250mg
Price: $30
Updated: 2021/12/16

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1-(2-Chloro-6-hydroxyphenyl)ethanone Chemical Properties,Usage,Production

Uses

1-(2-Chloro-6-hydroxyphenyl)ethanone is used for synthesis and structure-activity relationship of novel spiropiperidine-based stearoyl-CoA desaturase-1 inhibitors.

Preparation

Preparation by diazotization of 2-amino-6-chloro-acetophenone, followed by hydrolysis of the obtained diazonium salt (55%).

Synthesis

89999-90-6

75-16-1

55736-04-4

1. To a solution of 2-chloro-6-hydroxybenzonitrile (614 mg, 4 mmol) in tetrahydrofuran (THF, 10 mL) under argon protection is slowly added a solution of methylmagnesium bromide in toluene/THF (3:1, 1.4 M, 6.4 mL, 9 mmol). Note: Gas escapes during the reaction. 2. Stir the reaction mixture at room temperature until the escape of gas ceases. 3. Transfer the reaction mixture to a sealed tube and stir overnight at 65°C. 4. 4. upon completion of the reaction, the reaction is quenched with water and acidified with aqueous hydrochloric acid. 5. The organic layer containing 1-(2-chloro-6-hydroxyphenyl)ethanone was extracted with dichloromethane (DCM). 6. The product was purified by column chromatography using dichloromethane/hexane (1:1) as eluent to afford 1-(2-chloro-6-hydroxyphenyl)ethanone (100 mg, 15% yield).

References

[1] Patent: WO2010/56631, 2010, A1. Location in patent: Page/Page column 132-134

1-(2-Chloro-6-hydroxyphenyl)ethanone Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(2-Chloro-6-hydroxyphenyl)ethanone Suppliers

China 76 Germany 1 India 1 United Kingdom 2 United States 6 Global 86

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55736-04-4, 1-(2-Chloro-6-hydroxyphenyl)ethanoneRelated Search:

1-(2-Chloro-6-hydroxyphenyl)ethanone

2'-Chloro-6'-hydroxyacetophenone

Ethanone, 1-(2-chloro-6-hydroxyphenyl)-

1-(2-Chloro-6-hydroxyphenyl)

1-(2-Chloro-6-hydroxyphenyl)ethan-1-one 97+%

oro-6-hydroxyphenyL

2’-Chloro-6’-hydroxyacetophenone

55736-04-4