ChemicalBook > CAS DataBase List > 1-(2-Chloro-6-hydroxyphenyl)ethanone

1-(2-Chloro-6-hydroxyphenyl)ethanone

Product Name
1-(2-Chloro-6-hydroxyphenyl)ethanone
CAS No.
55736-04-4
Chemical Name
1-(2-Chloro-6-hydroxyphenyl)ethanone
Synonyms
oro-6-hydroxyphenyL;1-(2-Chloro-6-hydroxyphenyl);2’-Chloro-6’-hydroxyacetophenone;2'-Chloro-6'-hydroxyacetophenone;1-(2-Chloro-6-hydroxyphenyl)ethanone;Ethanone, 1-(2-chloro-6-hydroxyphenyl)-;1-(2-Chloro-6-hydroxyphenyl)ethan-1-one 97+%
CBNumber
CB52470017
Molecular Formula
C8H7ClO2
Formula Weight
170.59
MOL File
55736-04-4.mol
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1-(2-Chloro-6-hydroxyphenyl)ethanone Property

Boiling point:
225.4±20.0 °C(Predicted)
Density 
1.298±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
9.20±0.10(Predicted)
Appearance
Off-white to yellow Solid
InChI
InChI=1S/C8H7ClO2/c1-5(10)8-6(9)3-2-4-7(8)11/h2-4,11H,1H3
InChIKey
RUSSVKYJPIADHS-UHFFFAOYSA-N
SMILES
C(=O)(C1=C(O)C=CC=C1Cl)C
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Safety

HS Code 
2914500090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C585620
Product name
1-(2-Chloro-6-hydroxyphenyl)ethanone
Packaging
50mg
Price
$45
Updated
2021/12/16
TRC
Product number
C585620
Product name
1-(2-Chloro-6-hydroxyphenyl)ethanone
Packaging
100mg
Price
$75
Updated
2021/12/16
TRC
Product number
C585620
Product name
1-(2-Chloro-6-hydroxyphenyl)ethanone
Packaging
500mg
Price
$165
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC153387
Product name
1-?(2-?Chloro-6-hydroxyphenyl)ethanone
Packaging
100mg
Price
$220
Updated
2021/12/16
AK Scientific
Product number
J94265
Product name
1-(2-Chloro-6-hydroxyphenyl)ethanone
Packaging
250mg
Price
$30
Updated
2021/12/16
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1-(2-Chloro-6-hydroxyphenyl)ethanone Chemical Properties,Usage,Production

Uses

1-(2-Chloro-6-hydroxyphenyl)ethanone is used for synthesis and structure-activity relationship of novel spiropiperidine-based stearoyl-CoA desaturase-1 inhibitors.

Preparation

Preparation by diazotization of 2-amino-6-chloro-acetophenone, followed by hydrolysis of the obtained diazonium salt (55%).

Synthesis

89999-90-6

75-16-1

55736-04-4

1. To a solution of 2-chloro-6-hydroxybenzonitrile (614 mg, 4 mmol) in tetrahydrofuran (THF, 10 mL) under argon protection is slowly added a solution of methylmagnesium bromide in toluene/THF (3:1, 1.4 M, 6.4 mL, 9 mmol). Note: Gas escapes during the reaction. 2. Stir the reaction mixture at room temperature until the escape of gas ceases. 3. Transfer the reaction mixture to a sealed tube and stir overnight at 65°C. 4. 4. upon completion of the reaction, the reaction is quenched with water and acidified with aqueous hydrochloric acid. 5. The organic layer containing 1-(2-chloro-6-hydroxyphenyl)ethanone was extracted with dichloromethane (DCM). 6. The product was purified by column chromatography using dichloromethane/hexane (1:1) as eluent to afford 1-(2-chloro-6-hydroxyphenyl)ethanone (100 mg, 15% yield).

References

[1] Patent: WO2010/56631, 2010, A1. Location in patent: Page/Page column 132-134

1-(2-Chloro-6-hydroxyphenyl)ethanone Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(2-Chloro-6-hydroxyphenyl)ethanone Suppliers

China 76 Germany 1 India 1 United Kingdom 2 United States 6 Global 86
Alchem Pharmtech,Inc.
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8485655694
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Aladdin Scientific
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tp@aladdinsci.com
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Aceschem Inc.
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+1-817863-6948 +1-（817）863-6948
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19632
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Synthonix Inc
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SynQuest Laboratories, Inc.
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United States
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Matrix Scientific
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Email
sales@matrixscientific.com
Country
United States
ProdList
6632
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80

55736-04-4, 1-(2-Chloro-6-hydroxyphenyl)ethanoneRelated Search:


  • 1-(2-Chloro-6-hydroxyphenyl)ethanone
  • 2'-Chloro-6'-hydroxyacetophenone
  • Ethanone, 1-(2-chloro-6-hydroxyphenyl)-
  • 1-(2-Chloro-6-hydroxyphenyl)
  • 1-(2-Chloro-6-hydroxyphenyl)ethan-1-one 97+%
  • oro-6-hydroxyphenyL
  • 2’-Chloro-6’-hydroxyacetophenone
  • 55736-04-4