7-bromo-3,4-dihydroquinazolin-2(1H)-one
- Product Name
- 7-bromo-3,4-dihydroquinazolin-2(1H)-one
- CAS No.
- 1207175-68-5
- Chemical Name
- 7-bromo-3,4-dihydroquinazolin-2(1H)-one
- Synonyms
- 7-Bromo-3,4-dihydroquinazolin-2(1H);7-BroMo-3,4-dihydro-2(1H)-quinazolinone;7-bromo-3,4-dihydroquinazolin-2(1H)-one;2(1H)-Quinazolinone, 7-bromo-3,4-dihydro-
- CBNumber
- CB52470512
- Molecular Formula
- C8H7BrN2O
- Formula Weight
- 227.06
- MOL File
- 1207175-68-5.mol
7-bromo-3,4-dihydroquinazolin-2(1H)-one Property
- Boiling point:
- 294.0±40.0 °C(Predicted)
- Density
- 1.610
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 13.11±0.20(Predicted)
- Appearance
- White to off-white Powder
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 8526DG
- Product name
- 7-Bromo-3,4-dihydroquinazolin-2(1H)-one
- Packaging
- 10g
- Price
- $2535
- Updated
- 2021/12/16
- Product number
- CD11331911
- Product name
- 7-Bromo-3,4-dihydroquinazolin-2(1H)-one
- Purity
- 97+%
- Packaging
- 100mg
- Price
- $79
- Updated
- 2021/12/16
- Product number
- CD11331911
- Product name
- 7-Bromo-3,4-dihydroquinazolin-2(1H)-one
- Purity
- 97+%
- Packaging
- 250mg
- Price
- $127
- Updated
- 2021/12/16
- Product number
- 61-5330
- Product name
- 7-bromo-3,4-dihydroquinazolin-2(1H)-one
- Purity
- 98%
- Packaging
- 1g
- Price
- $200
- Updated
- 2021/12/16
- Product number
- CD11331911
- Product name
- 7-Bromo-3,4-dihydroquinazolin-2(1H)-one
- Purity
- 97+%
- Packaging
- 1g
- Price
- $317
- Updated
- 2021/12/16
7-bromo-3,4-dihydroquinazolin-2(1H)-one Chemical Properties,Usage,Production
Synthesis
624813-49-6
530-62-1
1207175-68-5
At room temperature, 2-(aminomethyl)-5-bromoaniline (0.90 g, 4.5 mmol) was dissolved in tetrahydrofuran (10 mL), followed by the addition of N,N'-carbonyldiimidazole (0.80 g, 4.9 mmol). The reaction mixture was heated to 80 °C with continuous stirring for 6 hours. Upon completion of the reaction, the mixture was cooled to room temperature, the resulting solid was collected by filtration and washed with ether to afford 7-bromo-3,4-dihydroquinazolin-2(1H)-one (0.73 g, 72% yield) as an off-white solid.IR (KBr) νmax/cm-1 : 3308, 3158 (NH), 3022 (Ar-H), 1682 (C=O). 1514, 1411 (C=C).1H NMR (500 MHz, DMSO-d6) δ: 5.25 (s, 2H, CH2); 6.82 (d, 1H, J=8.2 Hz, H-5); 7.42 (m, 2H, H-4, H-6); 10.29 (br.s, 1H, NH).13C NMR (125.7 MHz. DMSO-d6) δ: 66.85 (CH2), 113.70 (C-10), 115.70 (C-8), 121.03 (C-7), 127.52 (C-6), 131.41 (C-5), 135.88 (C-9), 151.42 (C=O). Elemental analysis calculated values (%) C8H7BrN2O (225.97): C: 42.32, H: 3.11, N: 12.34; measured values (%): C: 42.27, H: 3.16, N: 12.28.
References
[1] Medicinal Chemistry, 2014, vol. 10, # 5, p. 484 - 496
[2] Patent: US8916704, 2014, B1. Location in patent: Page/Page column 9
7-bromo-3,4-dihydroquinazolin-2(1H)-one Preparation Products And Raw materials
Raw materials
Preparation Products
7-bromo-3,4-dihydroquinazolin-2(1H)-one Suppliers
- Tel
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- enquiries@fluorochem.co.uk
- Country
- United Kingdom
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