Ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate

Product Name: Ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate
CAS No.: 105486-72-4
Chemical Name: Ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate
Synonyms: Ethyl 5-bromo-1-methyl-1h-pyrazole-4-formate;ethyl 5-bromo-1-methyl-pyrazole-4-carboxylate;Ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate;5-Bromo-1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester;1H-PYRAZOLE-4-CARBOXYLIC ACID, 5-BROMO-1-METHYL-, ETHYL ESTER;5-bromo-1-methyl-1H-Pyrazole-4-carboxylic acid ethyl ester (9CI ACI);1H-Pyrazole-4-carboxylic acid, 5-bromo-1-methyl-, ethyl ester (9CI, ACI)
CBNumber: CB52471504
Molecular Formula: C7H9BrN2O2
Formula Weight: 233.06
MOL File: 105486-72-4.mol

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Ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate Property

Boiling point:: 290.7±20.0 °C(Predicted)
Density: 1.58±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -1.13±0.10(Predicted)
Appearance: White to yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: HCH0368923
Product name: ETHYL-5-BROMO-1-METHYL-1H-PYRAZOLE-4-CARBOXYLATE
Purity: 95.00%
Packaging: 5MG
Price: $500.6
Updated: 2021/12/16

AK Scientific

Product number: 1249AA
Product name: Ethyl5-bromo-1-methyl-1H-pyrazole-4-carboxylate
Packaging: 1g
Price: $284
Updated: 2021/12/16

Ambeed

Product number: A155081
Product name: Ethyl5-bromo-1-methyl-1H-pyrazole-4-carboxylate
Purity: 95%
Packaging: 5g
Price: $464
Updated: 2021/12/16

Alichem

Product number: 105486724
Product name: 5-Bromo-1-methyl-1h-pyrazole-4-carboxylicacidethylester
Packaging: 5g
Price: $507.91
Updated: 2021/12/16

Crysdot

Product number: CD11359068
Product name: Ethyl5-bromo-1-methyl-1H-pyrazole-4-carboxylate
Purity: 95+%
Packaging: 5g
Price: $535
Updated: 2021/12/16

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Ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate Chemical Properties,Usage,Production

Synthesis

31037-02-2

105486-72-4

General procedure for the synthesis of ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate from ethyl 5-amino-1-methylpyrazole-4-carboxylate: Intermediate 1: (5-bromo-1-methyl-1H-pyrazol-4-yl)-(octahydro-quinolin-1-yl)methanone; Step 1: To a mixed solution containing tert-butyl nitrite (29.5 mL, 221.5 mmol), copper bromide (39.7 g, 177.5 mmol), and acetonitrile, ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate (25 g, 148 mmol) was slowly added over a 30-minute period. The reaction mixture was stirred at room temperature for 2 hours, followed by warming up to 65 °C and continued stirring for 1 hour. After completion of the reaction, the mixture was poured into 6N HCl (400 mL) and extracted with dichloromethane. The organic phase was concentrated in vacuum and the resulting crude product was purified by fast chromatography using a 0-20% ethyl acetate/hexane gradient elution to give ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate (28 g, 81% yield).

References

[1] Patent: US2006/223852, 2006, A1. Location in patent: Page/Page column 10
[2] Patent: WO2013/189904, 2013, A1. Location in patent: Page/Page column 49
[3] Patent: US2012/214791, 2012, A1. Location in patent: Page/Page column 23
[4] Journal of Medicinal Chemistry, 2018, vol. 61, # 3, p. 1001 - 1018

Ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate Suppliers

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105486-72-4, Ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylateRelated Search:

Ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate

5-Bromo-1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester

1H-PYRAZOLE-4-CARBOXYLIC ACID, 5-BROMO-1-METHYL-, ETHYL ESTER

Ethyl 5-bromo-1-methyl-1h-pyrazole-4-formate

ethyl 5-bromo-1-methyl-pyrazole-4-carboxylate

1H-Pyrazole-4-carboxylic acid, 5-bromo-1-methyl-, ethyl ester (9CI, ACI)

5-bromo-1-methyl-1H-Pyrazole-4-carboxylic acid ethyl ester (9CI ACI)

105486-72-4