ChemicalBook > CAS DataBase List > CJ-42794

CJ-42794

Product Name
CJ-42794
CAS No.
847728-01-2
Chemical Name
CJ-42794
Synonyms
CJ-42794;CJ-042794;RQ-00015986;CJ-042794 (CJ-042794);CJ-042794;CJ42794;CJ 42794;4-((S)-1-(2-(4-fluorophenoxy)-5-chlorobenzamido)ethyl)benzoic acid;(S)-4-(1-(5-chloro-2-(4-fluorophenoxy)benzaMido)ethyl)benzoic acid;4-[(1S)-1-[[5-chloro-2-(4-fluorophenoxy)benzoyl]amino]ethyl]Benzoic acid;Benzoic acid, 4-[(1S)-1-[[5-chloro-2-(4-fluorophenoxy)benzoyl]amino]ethyl]-;prostaglandin E2,tumor necrosis factor α,cAMP,CJ 42794,gastric ulcers,CJ042794,CJ 042794,NR3C3,inhibit,CJ-42794,human whole blood,Progesterone Receptor,Inhibitor,CJ42794
CBNumber
CB52473902
Molecular Formula
C22H17ClFNO4
Formula Weight
413.83
MOL File
847728-01-2.mol
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CJ-42794 Property

Boiling point:
572.7±50.0 °C(Predicted)
Density 
1.347±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
insoluble in H2O; ≥11.7 mg/mL in DMSO; ≥54.6 mg/mL in EtOH
form 
A crystalline solid
pka
4.21±0.10(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10010428
Product name
CJ-42794
Purity
≥98%
Packaging
10mg
Price
$53
Updated
2024/03/01
Cayman Chemical
Product number
10010428
Product name
CJ-42794
Purity
≥98%
Packaging
50mg
Price
$227
Updated
2024/03/01
Cayman Chemical
Product number
10010428
Product name
CJ-42794
Purity
≥98%
Packaging
100mg
Price
$399
Updated
2024/03/01
Cayman Chemical
Product number
10010428
Product name
CJ-42794
Purity
≥98%
Packaging
250mg
Price
$747
Updated
2024/03/01
Matrix Scientific
Product number
095360
Product name
(S)-4-(1-(5-Chloro-2-(4-fluorophenoxy)-benzamido)ethyl)benzoic acid
Purity
95+%
Packaging
1g
Price
$750
Updated
2021/12/16
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CJ-42794 Chemical Properties,Usage,Production

Definition

ChEBI: Benzoic acid, 4-[(1s)-1-[[5-chloro-2-(4-fluorophenoxy)benzoyl]amino]ethyl]- is an aromatic ether.

Biological Activity

ki: 3.16 nm: antagonizes e prostanoid receptor 4 (ep4).ki: 631 nm: antagonizes ep2.cj-42794, as a selective antagonist of ep4, less binds to ep2 and does not have binding affinity for ep1 or ep3. it displays minimal effect on numerous other receptors, channels, or enzymes. cj-42794 delays the healing of gastric ulcers, inhibiting the upregulation of vegf expression and angiogenesis. ep4, activated by prostaglandin e2 (pge2), is a g-protein-coupled receptor, which plays vital roles in bone formation and resorption, cancer, and atherosclerosis via elevating the second messenger cyclic amp (camp).

in vitro

cj-42794 exhibited remarkable binding activity to ep4 and suppressed pge2-triggered elevations of intracellular camp levels in a concentration-dependent fashion in hek293 cells overexpressing human ep4. moreover, cj-42794, concentration-dependently, reversed the inhibitory effects of pge2 on lipopolysaccharide-evoked tumor necrosis factor α production, which suggested that cj-42794 had excellent pharmacological properties used for exploring the physiological role of ep4 [1].

in vivo

male sprague-dawley rats and c57bl/6 mice were given subcutaneously 3 and 10 mg/kg for rats, 10 mg/kg for mice once daily for 7 or 14 days. compared to the controls, cj-42794, in a dose-dependent manner, impaired and delayed the gastric ulcer healing in rats and mice. cj-42794 markedly dampened the increase of vegf expression in ulcerated mucosa of the mouse stomach and the primary gastric fibroblasts of rat [2].

References

[1]. murase, a., taniguchi, y., tonai-kachi, h., nakao, k., & takada, j. in vitro pharmacological characterization of cj-042794, a novel, potent, and selective prostaglandin ep4 receptor antagonist. life sciences. 2008; 82(3-4): 226-232.
[2]. hatazawa, r., tanaka, a., tanigami, m., amagase, k., kato, s., ashida, y., & takeuchi, k. cyclooxygenase-2/prostaglandin e2 accelerates the healing of gastric ulcers via ep4 receptors. ajp: gastrointestinal and liver physiology. 2007; 293(4): g788-g797.

CJ-42794 Preparation Products And Raw materials

Raw materials

Preparation Products

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CJ-42794 Suppliers

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847728-01-2, CJ-42794Related Search:


  • 4-[(1S)-1-[[5-chloro-2-(4-fluorophenoxy)benzoyl]amino]ethyl]Benzoic acid
  • (S)-4-(1-(5-chloro-2-(4-fluorophenoxy)benzaMido)ethyl)benzoic acid
  • CJ-042794
  • 4-((S)-1-(2-(4-fluorophenoxy)-5-chlorobenzamido)ethyl)benzoic acid
  • CJ-42794
  • CJ-042794;CJ42794;CJ 42794
  • Benzoic acid, 4-[(1S)-1-[[5-chloro-2-(4-fluorophenoxy)benzoyl]amino]ethyl]-
  • RQ-00015986
  • prostaglandin E2,tumor necrosis factor α,cAMP,CJ 42794,gastric ulcers,CJ042794,CJ 042794,NR3C3,inhibit,CJ-42794,human whole blood,Progesterone Receptor,Inhibitor,CJ42794
  • CJ-042794 (CJ-042794)
  • 847728-01-2
  • C22H17ClFNO4