PIK-75

Product Name: PIK-75
CAS No.: 372196-67-3
Chemical Name: PIK-75
Synonyms: CS-669;PIK 75;PIK75(HCl salt);PIK-75, free base;PIK-75 Hydrochloride;PI3-Kinase a Inhibitor VIII;N'-((6-Bromoimidazo[1,2-a]pyridin-3-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide;N'-((6-Bromoimidazo[1,2-a]pyridin-3-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide;(Z)-N'-((6-bromoimidazo[1,2-a]pyridin-3-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide;2-Methyl-5-nitro-1-benzenesulfonic acid 2-[(6-bromoimidazo[1,2-a]pyridin-3-yl)methylene]-1-methylhydrazide
CBNumber: CB52484861
Molecular Formula: C16H14BrN5O4S
Formula Weight: 452.28
MOL File: 372196-67-3.mol

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PIK-75 Property

Melting point:: >203°C (dec.)
Density: 1.66±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Heated)
form: Solid
pka: 2.08±0.50(Predicted)
color: Light Yellow to Yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Usbiological

Product number: 462617
Product name: PIK-75
Packaging: 1mg
Price: $312
Updated: 2021/12/16

TRC

Product number: P437670
Product name: PIK-75
Packaging: 50mg
Price: $340
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb181090
Product name: PIK-75
Purity: >98%
Packaging: 250mg
Price: $912.9
Updated: 2021/12/16

Matrix Scientific

Product number: 132629
Product name: (E)-N'-((6-Bromoimidazo[1,2-a]pyridin-3-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide
Purity: 97%
Packaging: 100mg
Price: $1080
Updated: 2021/12/16

Adipogen Life Sciences

Product number: SYN-1067-M005
Product name: PIK-75
Purity: ≥95%
Packaging: 5mg
Price: $70
Updated: 2021/12/16

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PIK-75 Chemical Properties,Usage,Production

Uses

PIK-75 is a p110α inhibitor, isoform-specific mutants at Ser773, and also potently inhibits DNA-PK.

Definition

ChEBI: N-[(6-bromo-3-imidazo[1,2-a]pyridinyl)methylideneamino]-N,2-dimethyl-5-nitrobenzenesulfonamide is a sulfonamide.

Enzyme inhibitor

This novel phosphoinositide-3 kinase p110α inhibitor (F.Wt. = 488.74; CAS 372196-67-3; Solubility (25°C): 98 mg/mL DMSO, <1 mg/mL Water), also known as (E)-N'-((6-bromoH-imidazo[1,2-a]pyridin-3-yl)methylene)-N,2- dimethyl-5-nitrobenzenesulfonohydrazide-HCl, competes with respect to a substrate (phosphatidylinositol, PI), unlike most other PI3K inhibitors, which bind at or near the ATP site. PIK-75 exhibits impressive isoform selectivity, with an IC50 value of 5.8 nM for p110α, while the corresponding IC50 values are 1300 nM, 76 nM and 510 nM for p110β, p110γ, and p110δ, respectively.

PIK-75 Preparation Products And Raw materials

Raw materials

Preparation Products

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PIK-75 Suppliers

China 67 Germany 1 The Netherlands 1 United Kingdom 2 United States 15 Global 86

Shanghai Boyle Chemical Co., Ltd.

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Email: sales@boylechem.com
Country: China
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Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6005
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Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15402
Advantage: 60

Nanjing JinruiJiuAn Biotechnology Co., Ltd.

Tel: 025-58196018 800028039
Fax: 025-83453306
Email: sales@fartop.net
Country: China
ProdList: 2229
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SYN|thesis med chem P/L

Tel: +86-021-50720296
Fax: +86-021-50720297
Email: service@synkinase.com
Country: China
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ShangHai YingYi Chemical Technology Co., Ltd.

Tel: 86-21-50700185 13764109623
Fax: 86-21-50700185
Email: sale@inyelchem.com
Country: China
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ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3466
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Pharmacodia (Beijing) Co.,Ltd

Tel: +86-400-851-9921
Fax: +86-10-82826195
Email: sales@pharmacodia.com
Country: China
ProdList: 2317
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Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
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Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
Country: United States
ProdList: 2559
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372196-67-3, PIK-75Related Search:

2-Methyl-5-nitro-1-benzenesulfonic acid 2-[(6-bromoimidazo[1,2-a]pyridin-3-yl)methylene]-1-methylhydrazide

PIK-75 Hydrochloride

Benzenesulfonic acid, 2-Methyl-5-nitro-, 2-[(6-broMoiMidazo[1,2-a]pyridin-3-yl)Methylene]-1-Methylhydrazide

PIK75(HCl salt)

PI3-Kinase a Inhibitor VIII

PIK 75

CS-669

PIK-75, free base

(Z)-N'-((6-bromoimidazo[1,2-a]pyridin-3-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide

N'-((6-Bromoimidazo[1,2-a]pyridin-3-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide

PIK-75,pancreatic,PKB,cells,apoptotic,p110α,inhibit,PI3K,Phosphoinositide 3-kinase,DNA-PK,PIK75,cancer,Inhibitor,CHO-IR,DNA-dependent protein kinase,Apoptosis,PIK 75

N'-((6-Bromoimidazo[1,2-a]pyridin-3-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide

372196-67-3

C16H14BrN5O4S

Inhibitors

Antineoplastic