ChemicalBook > CAS DataBase List > PIK-75

PIK-75

Product Name
PIK-75
CAS No.
372196-67-3
Chemical Name
PIK-75
Synonyms
CS-669;PIK 75;PIK75(HCl salt);PIK-75, free base;PIK-75 Hydrochloride;PI3-Kinase a Inhibitor VIII;N'-((6-Bromoimidazo[1,2-a]pyridin-3-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide;N'-((6-Bromoimidazo[1,2-a]pyridin-3-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide;(Z)-N'-((6-bromoimidazo[1,2-a]pyridin-3-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide;2-Methyl-5-nitro-1-benzenesulfonic acid 2-[(6-bromoimidazo[1,2-a]pyridin-3-yl)methylene]-1-methylhydrazide
CBNumber
CB52484861
Molecular Formula
C16H14BrN5O4S
Formula Weight
452.28
MOL File
372196-67-3.mol
More
Less

PIK-75 Property

Melting point:
>203°C (dec.)
Density 
1.66±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Heated)
form 
Solid
pka
2.08±0.50(Predicted)
color 
Light Yellow to Yellow
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Usbiological
Product number
462617
Product name
PIK-75
Packaging
1mg
Price
$312
Updated
2021/12/16
TRC
Product number
P437670
Product name
PIK-75
Packaging
50mg
Price
$340
Updated
2021/12/16
Biorbyt Ltd
Product number
orb181090
Product name
PIK-75
Purity
>98%
Packaging
250mg
Price
$912.9
Updated
2021/12/16
Matrix Scientific
Product number
132629
Product name
(E)-N'-((6-Bromoimidazo[1,2-a]pyridin-3-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide
Purity
97%
Packaging
100mg
Price
$1080
Updated
2021/12/16
Adipogen Life Sciences
Product number
SYN-1067-M005
Product name
PIK-75
Purity
≥95%
Packaging
5mg
Price
$70
Updated
2021/12/16
More
Less

PIK-75 Chemical Properties,Usage,Production

Uses

PIK-75 is a p110α inhibitor, isoform-specific mutants at Ser773, and also potently inhibits DNA-PK.

Definition

ChEBI: N-[(6-bromo-3-imidazo[1,2-a]pyridinyl)methylideneamino]-N,2-dimethyl-5-nitrobenzenesulfonamide is a sulfonamide.

Enzyme inhibitor

This novel phosphoinositide-3 kinase p110α inhibitor (F.Wt. = 488.74; CAS 372196-67-3; Solubility (25°C): 98 mg/mL DMSO, <1 mg/mL Water), also known as (E)-N'-((6-bromoH-imidazo[1,2-a]pyridin-3-yl)methylene)-N,2- dimethyl-5-nitrobenzenesulfonohydrazide-HCl, competes with respect to a substrate (phosphatidylinositol, PI), unlike most other PI3K inhibitors, which bind at or near the ATP site. PIK-75 exhibits impressive isoform selectivity, with an IC50 value of 5.8 nM for p110α, while the corresponding IC50 values are 1300 nM, 76 nM and 510 nM for p110β, p110γ, and p110δ, respectively.

PIK-75 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

PIK-75 Suppliers

China 67 Germany 1 The Netherlands 1 United Kingdom 2 United States 15 Global 86
Novachemistry
Tel
44-20819178-90 02081917890
Fax
(0)2080432064
Email
info@novachemistry.com
Country
United Kingdom
ProdList
4381
Advantage
58
Apollo Scientific Ltd.
Tel
--
Fax
--
Email
sales@apolloscientific.co.uk
Country
United Kingdom
ProdList
6084
Advantage
88

372196-67-3, PIK-75Related Search:


  • 2-Methyl-5-nitro-1-benzenesulfonic acid 2-[(6-bromoimidazo[1,2-a]pyridin-3-yl)methylene]-1-methylhydrazide
  • PIK-75 Hydrochloride
  • Benzenesulfonic acid, 2-Methyl-5-nitro-, 2-[(6-broMoiMidazo[1,2-a]pyridin-3-yl)Methylene]-1-Methylhydrazide
  • PIK75(HCl salt)
  • PI3-Kinase a Inhibitor VIII
  • PIK 75
  • CS-669
  • PIK-75, free base
  • (Z)-N'-((6-bromoimidazo[1,2-a]pyridin-3-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide
  • N'-((6-Bromoimidazo[1,2-a]pyridin-3-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide
  • PIK-75,pancreatic,PKB,cells,apoptotic,p110α,inhibit,PI3K,Phosphoinositide 3-kinase,DNA-PK,PIK75,cancer,Inhibitor,CHO-IR,DNA-dependent protein kinase,Apoptosis,PIK 75
  • N'-((6-Bromoimidazo[1,2-a]pyridin-3-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide
  • 372196-67-3
  • C16H14BrN5O4S
  • Inhibitors
  • Antineoplastic