Olodaterol
- Product Name
- Olodaterol
- CAS No.
- 868049-49-4
- Chemical Name
- Olodaterol
- Synonyms
- Olodaterol free base;BI-1744;Striverdi;Olodaterol;OLODATEROL D3;BI 1744(Olodaterol;Striverdi Respimat);Olodaterol USP/EP/BP;Olodaterol ImpurityＡ ;Olodaterol Discontinued
- CBNumber
- CB52484977
- Molecular Formula
- C21H26N2O5
- Formula Weight
- 386.44
- MOL File
- 868049-49-4.mol
Olodaterol Property
- Boiling point:
- 649.0±55.0 °C(Predicted)
- Density
- 1.250
- solubility
- DMF: 20 mg/ml; DMF:PBS (pH 7.2) (1:3): 0.25 mg/ml; DMSO: 15 mg/ml; Ethanol: 1 mg/ml
- form
- A crystalline solid
- pka
- 9.42±0.20(Predicted)
- color
- Light yellow to khaki
- Stability:
- Hygroscopic
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
H372Causes damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P314Get medical advice/attention if you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 21794
- Product name
- Olodaterol
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $89
- Updated
- 2024/03/01
- Product number
- 21794
- Product name
- Olodaterol
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $289
- Updated
- 2024/03/01
- Product number
- 21794
- Product name
- Olodaterol
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $490
- Updated
- 2024/03/01
- Product number
- 21794
- Product name
- Olodaterol
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $1113
- Updated
- 2024/03/01
- Product number
- FH152793
- Product name
- Olodaterol
- Packaging
- 25mg
- Price
- $325
- Updated
- 2021/12/16
Olodaterol Chemical Properties,Usage,Production
Description
In 2013, olodaterol (also known BI-1744 CL) was approved for the treatment of chronic obstructive pulmonary disease (COPD) in Russia (March), Canada (June), and the EuropeanUnion (October). Olodaterol is delivered via the Respimat? Soft Mist? inhaler. Olodaterol was discovered from an effort to identify a β2-adrenergic receptor agonist that could be given once daily and with a superior safety profile over known β2- adrenergic receptor agonists. Olodaterol is a potent β2 agonist (EC50=0.1 nM, intrinsic activity=88%) and is highly selective for the β2 receptor over β1 and β3 receptors. In preclinical models in guinea pigs and dogs, olodaterol had a rapid onset of action and provided bronchoprotection over 24 h. Mechanistic studies indicated that olodaterol forms a highly stable complex with the β2-adrenergic receptor, with a dissociation half-life of 17.8 h. The synthesis of olodaterol proceeds through an (R)-styrene epoxide that is prepared via enantioselective reduction of an α-chloroketone intermediate. Ring opening of the epoxide with 1-(4- methoxyphenyl)-2-methylpropan-2-amine provides olodaterol.
Originator
Boehringer-Ingelheim (European Union)
Uses
Olodaterol-d3 is labelled Olodaterol (O262000) which is a long acting b-adrenoceptor agonist used as an inhalation for treating patients with chronic obstructive pulmonary disease (COPD).
Definition
ChEBI: A member of the class of benzoxazine that is 6-hydroxy-1,4-benzoxazin-3-one in which the hydrogen at position 4 is replaced by a (1R)-1-hydroxy-2-{[1-(4-methoxyphenyl)-2-methylpropan-2-yl]amino}ethyl group. Used (as its hydrochloride salt) for long-term treatment of airflow obstruction in patients with chronic obstructive pulmonary disease including chronic bronchitis and/or emphysema.
brand name
Striverdi
Olodaterol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Olodaterol manufacturers
- Product
- olodaterol 868049-49-4
- Price
- US $50.00/KG
- Min. Order
- 1KG
- Purity
- 0.99
- Supply Ability
- 10000
- Release date
- 2023-09-06
- Product
- Olodaterol 868049-49-4
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- Olodaterol 868049-49-4
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09