ChemicalBook > CAS DataBase List > Thiamet G Discontinued

Thiamet G Discontinued

Product Name
Thiamet G Discontinued
CAS No.
1009816-48-1
Chemical Name
Thiamet G Discontinued
Synonyms
CS-1700;Thiamet G;Thiamet H;Thiamet G0nDiscontinued;Thiamet G Discontinued ;Thiamet G_x000b_Discontinued;1,2-Dideoxy-2'-ethylamino-a-D-glucopyranoso-[2,1-d]-2'-thiazoline;2-(ethylaMino)-5-(hydroxyMethyl)-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]thiazole-6,7-dio;2-(ethylamino)-3aR,6S,7R,7aR-tetrahydro-5R-(hydroxymethyl)-5H-pyrano[3,2-d]thiazole-6,7-diol;(3aR,5R,6S,7R,7aR)-2-(Ethylamino)-5-(hydroxymethyl)-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]thiazole-6,7-diol
CBNumber
CB52485666
Molecular Formula
C9H16N2O4S
Formula Weight
248.3
MOL File
1009816-48-1.mol
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Thiamet G Discontinued Property

Boiling point:
483.2±55.0 °C(Predicted)
Density 
1.74±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
H2O: ≥5mg/mL at warmed to 60°C
form 
powder
pka
13.17±0.70(Predicted)
color 
white to beige
optical activity
[α]/D -21 to -26°, c = 0.3 in methanol
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChIKey
PPAIMZHKIXDJRN-UKPHHSARSA-N
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0244
Product name
Thiamet G
Purity
≥98% (HPLC)
Packaging
5mg
Price
$127
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0244
Product name
Thiamet G
Purity
≥98% (HPLC)
Packaging
25mg
Price
$505
Updated
2024/03/01
Cayman Chemical
Product number
13237
Product name
Thiamet G
Purity
≥97%
Packaging
1mg
Price
$40
Updated
2024/03/01
Cayman Chemical
Product number
13237
Product name
Thiamet G
Purity
≥97%
Packaging
5mg
Price
$89
Updated
2024/03/01
Cayman Chemical
Product number
13237
Product name
Thiamet G
Purity
≥97%
Packaging
10mg
Price
$133
Updated
2024/03/01
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Thiamet G Discontinued Chemical Properties,Usage,Production

Description

Thiamet G (1009816-48-1) is a potent, selective inhibitor of O-GlcNAcase (Ki?= 21 nM for human O-GlcNAcase). Increases levels of O-GlcNAc-modified proteins in cellular assays and?in vivo. Suppresses phosphorylation of tau protein in rat cortex and hippocampus.1?Stabilizes tau against aggregation and slows neurodegeneration.2?Thiamet G prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice.3?Elevates soluble tau species and reduces tauopathy in mouse models.4?Active?in vivo?and blood brain barrier permeable.

Uses

A potent O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo. The authors anticipate that Thiamet-G will find wide use in probing the functional role of O-GlcNAc in vertebrate brain, and it may also offer a route to blocking pathological hyperphosphorylation of tau in AD. Anti-Alzheimer''s agent.

Uses

As a potent O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo, The authors anticipate that Thiamet-G will find wide use in probing the functional role of O-GlcNAc in vertebrate brain, and it may also offer a route to blocking pathological

Biochem/physiol Actions

Thiamet G is a potent inhibitor of the enzyme O-GlcNAcase (Ki = 21 nM). The compound is orally bioavailable and crosses the blood brain barrier. Thiamet G leads to an increase in O-GlcNAc-modified proteins in cell-based and in vivo assay systems, and reduces levels of phosphorylated Tau protein in rat cortex and hippocampus.

storage

Store at -20°C

References

1) Yuzwa?et al. (2008),?A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo; Nat. Chem. Biol.,?4?483 2) Yuzwa?et al. (2012),?Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation; Nat. Chem. Biol.?8?393 3) Yuzwa?et al. (2014),?Pharmacological inhibition of O-GlcNAcase (OGA) prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice; Mol. Neurodegener.,?9?42 4) Hastings?et al.?(2017)?Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice;?Mol. Neurodegener.,?12?39

Thiamet G Discontinued Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Thiamet G Discontinued manufacturers

Career Henan Chemical Co
Product
Thiamet G Discontinued 1009816-48-1
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2020-03-04
Career Henan Chemical Co
Product
Thiamet G 1009816-48-1
Price
US $9.80/KG
Min. Order
1KG
Purity
>98%HPLC
Supply Ability
20 tons
Release date
2020-02-06

1009816-48-1, Thiamet G Discontinued Related Search:


  • Thiamet G Discontinued
  • Thiamet G
  • 1,2-Dideoxy-2'-ethylamino-a-D-glucopyranoso-[2,1-d]-2'-thiazoline
  • 2-(ethylaMino)-5-(hydroxyMethyl)-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]thiazole-6,7-dio
  • 5H-Pyrano[3,2-d]thiazole-6,7-diol, 2-(ethylamino)-3a,6,7,7a-tetrahydro-5-(hydroxymethyl)-, (3aR,5R,6S,7R,7aR)-
  • (3aR,5R,6S,7R,7aR)-2-(ethylamino)-3a,6,7,7a-tetrahydro-5-(hydroxymethyl)-5H-Pyrano[3,2-d]thiazole-6,7-diol
  • (3aR,5R,6S,7R,7aR)-2-(Ethylamino)-5-(hydroxymethyl)-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]thiazole-6,7-diol
  • Thiamet G0nDiscontinued
  • CS-1700
  • (3aR,5R,6S,7R,7aR)-2-(ethylamino)-5-(hydroxymethyl)-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d][1,3]thiazole-6,7-diol
  • Thiamet G_x000b_Discontinued
  • Thiamet H
  • 2-(ethylamino)-3aR,6S,7R,7aR-tetrahydro-5R-(hydroxymethyl)-5H-pyrano[3,2-d]thiazole-6,7-diol
  • 1009816-48-1
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  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Sulfur & Selenium Compounds
  • API
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