methyl 2,6-dichloro-4-methylnicotinate

Product Name: methyl 2,6-dichloro-4-methylnicotinate
CAS No.: 1013648-04-8
Chemical Name: methyl 2,6-dichloro-4-methylnicotinate
Synonyms: methyl 2,6-dichloro-4-methylnicotinate;2,6-Dichloro-4-methylnicotinic acid methyl ester;methyl 2,6-dichloro-4-methyl-pyridine-3-carboxylate;2,6-Dichloro-4-methylpyridine-3-carboxylic acid methyl ester;3-Pyridinecarboxylic acid, 2,6-dichloro-4-methyl-, methyl ester
CBNumber: CB52489811
Molecular Formula: C8H7Cl2NO2
Formula Weight: 220.05
MOL File: 1013648-04-8.mol

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methyl 2,6-dichloro-4-methylnicotinate Property

Boiling point:: 292℃
Density: 1.369
Flash point:: 130℃
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -3.75±0.10(Predicted)
Appearance: Light brown to yellow Solid
InChI: InChI=1S/C8H7Cl2NO2/c1-4-3-5(9)11-7(10)6(4)8(12)13-2/h3H,1-2H3
InChIKey: QOTFUYQFPHLJTM-UHFFFAOYSA-N
SMILES: C1(Cl)=NC(Cl)=CC(C)=C1C(OC)=O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0061273
Product name: Methyl2,6-dichloro-4-methylnicotinate
Packaging: 250mg
Price: $59
Updated: 2021/12/16

ChemScene

Product number: CS-0061273
Product name: Methyl2,6-dichloro-4-methylnicotinate
Packaging: 1g
Price: $142
Updated: 2021/12/16

ChemScene

Product number: CS-0061273
Product name: Methyl2,6-dichloro-4-methylnicotinate
Packaging: 5g
Price: $440
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0050088
Product name: METHYL 2,6-DICHLORO-4-METHYLNICOTINATE
Purity: 95.00%
Packaging: 1G
Price: $945.95
Updated: 2021/12/16

AK Scientific

Product number: 0371AA
Product name: Methyl2,6-dichloro-4-methylnicotinate
Packaging: 10g
Price: $1130
Updated: 2021/12/16

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methyl 2,6-dichloro-4-methylnicotinate Chemical Properties,Usage,Production

Synthesis

62774-90-7

74-88-4

1013648-04-8

(A) Synthesis of methyl 2,6-dichloro-4-methylnicotinate: 8.05 g (39.1 mmol) of 2,6-dichloro-4-methylnicotinate [Lamm, G. Ger. Offen. (1977), DE 2538950] was dissolved in 100 mL of DMF, followed by the addition of 8.10 g (58.6 mmol) of potassium carbonate. Under stirring conditions, 12.16 mL (27.7 g, 195.4 mmol) of iodomethane was added slowly and dropwise. The reaction mixture was stirred continuously for 6 hours at room temperature. After completion of the reaction, the mixture was poured into crushed ice and extracted twice with EtOAc. The organic phases were combined, washed with water, dried over magnesium sulfate, filtered and the solvent evaporated to give 8.47 g (99% yield) of methyl 2,6-dichloro-4-methylnicotinate as a light yellow solid. Mass spectral data: 219.0 (M+, containing 2Cl).

References

[1] Patent: US2009/48238, 2009, A1. Location in patent: Page/Page column 22
[2] Patent: US2009/318467, 2009, A1. Location in patent: Page/Page column 23
[3] Patent: US2012/101079, 2012, A1. Location in patent: Page/Page column 74
[4] Patent: WO2012/52167, 2012, A1. Location in patent: Page/Page column 171-172
[5] Patent: US2017/183342, 2017, A1. Location in patent: Paragraph 0231

methyl 2,6-dichloro-4-methylnicotinate Preparation Products And Raw materials

Raw materials

Preparation Products

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methyl 2,6-dichloro-4-methylnicotinate Suppliers

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1013648-04-8, methyl 2,6-dichloro-4-methylnicotinateRelated Search:

Nicotinic acid

methyl 2,6-dichloro-4-methylnicotinate

2,6-Dichloro-4-methylnicotinic acid methyl ester

2,6-Dichloro-4-methylpyridine-3-carboxylic acid methyl ester

3-Pyridinecarboxylic acid, 2,6-dichloro-4-methyl-, methyl ester

methyl 2,6-dichloro-4-methyl-pyridine-3-carboxylate

1013648-04-8