tert-butyl azetidin-3-ylmethyl(methyl)carbamate
- Product Name
- tert-butyl azetidin-3-ylmethyl(methyl)carbamate
- CAS No.
- 1053655-53-0
- Chemical Name
- tert-butyl azetidin-3-ylmethyl(methyl)carbamate
- Synonyms
- 3-(N-Boc-Methylaminomethy...;3-[Boc(methyl)aminomethyl]azetidine,95%;3-[Boc(Methyl)aMinoMethyl]azetidine, 95%;N-Boc-1-(3-azetidinyl)-N-methylmethanamine;tert-butyl azetidin-3-ylmethyl(methyl)carbamate;tert-butyl N-(azetidin-3-ylmethyl)-N-methylcarbamate;1,1-Dimethylethyl N-(3-azetidinylmethyl)-N-methylcarbamate;N-(3-Azetidinylmethyl)-N-methylcarbamic acid tert-butyl ester;N-(3-azetidinylMethyl)-n-Methyl-carbaMic acid 1,1-diMethylethyl ester;Carbamic acid, N-(3-azetidinylmethyl)-N-methyl-, 1,1-dimethylethyl ester
- CBNumber
- CB52490295
- Molecular Formula
- C10H20N2O2
- Formula Weight
- 200.28
- MOL File
- 1053655-53-0.mol
tert-butyl azetidin-3-ylmethyl(methyl)carbamate Property
- Boiling point:
- 267℃
- Density
- 1.012
- Flash point:
- 116℃
- storage temp.
- 2-8°C(protect from light)
- pka
- 10.86±0.40(Predicted)
Safety
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- H60310
- Product name
- 3-[Boc(methyl)aminomethyl]azetidine, 95%
- Packaging
- 250mg
- Price
- $214
- Updated
- 2023/06/20
- Product number
- H60310
- Product name
- 3-[Boc(methyl)aminomethyl]azetidine, 95%
- Packaging
- 1g
- Price
- $612
- Updated
- 2023/06/20
- Product number
- B789533
- Product name
- tert-ButylAzetidin-3-ylmethyl(methyl)carbamate
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 059926
- Product name
- 3-(N-Boc-Methylaminomethyl)azetidine
- Purity
- 95%
- Packaging
- 500mg
- Price
- $475
- Updated
- 2021/12/16
- Product number
- 059926
- Product name
- 3-(N-Boc-Methylaminomethyl)azetidine
- Purity
- 95%
- Packaging
- 1g
- Price
- $612
- Updated
- 2021/12/16
tert-butyl azetidin-3-ylmethyl(methyl)carbamate Chemical Properties,Usage,Production
Uses
Tert-butyl azetidin-3-ylmethyl(methyl)carbamate is an important organic reagent that can be used as a building block for the synthesis of tert-butyl ((1-((4-chloro-7H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl)azetidin-3-yl)methyl)(methyl)carbamate which is an important intermediate of a selective small-molecule PLK inhibitors useful in the treatment of cell proliferative disorders.
Synthesis
A solution of tert-butyl ((1-benzhydrylazetidin-3-yl)methyl)carbamate (6.18 g, 17.53 mmol) in 50 mL of MeOH and 15 mL of EtOAc was purged with argon. Pd/C (10%, 50% in water) (929 mg) was added and the mixture was then purged again with argon and stirred in an H2 atmosphere for 18 h. The reaction was filtered through Ceitte and the filter was washed with EtOAc and MeOH, The resulting solvent was evaporated to dryness, providing 5.66 g of a mixture of tert-butyl azetidin-3-ylmethyl(methyl)carbamate together with one equivalent of diphenylmethane. The pure product tert-butyl azetidin-3-ylmethyl(methyl)carbamate was obtained after further purification.
tert-butyl azetidin-3-ylmethyl(methyl)carbamate Preparation Products And Raw materials
Raw materials
Preparation Products
tert-butyl azetidin-3-ylmethyl(methyl)carbamate Suppliers
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- 021-31261262/ 49 (0)17662837245
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