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Piperazine, 1-diphenylmethyl-4-methyl-, dihydrochloride

Product Name
Piperazine, 1-diphenylmethyl-4-methyl-, dihydrochloride
CAS No.
5897-18-7
Chemical Name
Piperazine, 1-diphenylmethyl-4-methyl-, dihydrochloride
Synonyms
Cyclizine 2HCl;Marzine hydrochloride;Cyclizine 2hydrochloride;Cyclizine dihydrochloride;Piperazine, 1-benzhydryl-4-methyl-, dihydrochloride;1-Diphenylmethyl-4-methylpiperazine dihydrochloride;Piperazine, 1-diphenylmethyl-4-methyl-, dihydrochloride;Piperazine, 1-(diphenylmethyl)-4-methyl-, hydrochloride (1:2);Piperazine, 1-diphenylmethyl-4-methyl-, dihydrochloride USP/EP/BP
CBNumber
CB52497865
Molecular Formula
C18H24Cl2N2
Formula Weight
339.30256
MOL File
5897-18-7.mol
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Piperazine, 1-diphenylmethyl-4-methyl-, dihydrochloride Property

storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
Soluble in DMSO > 10 mM
form 
Powder
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

AK Scientific
Product number
2344AH
Product name
Cyclizine2HCl
Packaging
25mg
Price
$129
Updated
2021/12/16
ApexBio Technology
Product number
B1548
Product name
Cyclizine2HCl
Packaging
50mg
Price
$146
Updated
2021/12/16
CSNpharm
Product number
CSN22573
Product name
Cyclizine2HCl
Packaging
10mg
Price
$36
Updated
2021/12/16
CSNpharm
Product number
CSN22573
Product name
Cyclizine2HCl
Packaging
50mg
Price
$61
Updated
2021/12/16
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Piperazine, 1-diphenylmethyl-4-methyl-, dihydrochloride Chemical Properties,Usage,Production

Uses

Cyclizine dihydrochloride, a piperazine-derivative, is a potent and selective histamine H1 receptor antagonist. Cyclizine dihydrochloride can be used for the research of nausea, vomiting, and dizziness[1][2][3].

Biological Activity

Cyclizine 2HCl is a piperazine derivative with Histamine H1 receptor antagonist activity.

in vitro

Cyclizine is a piperazine histamine H1 receptor antagonist and has anticholinergic and antiemetic properties. It increases lower esophageal sphincter tone and reduces the sensitivity of tortuous organs.

in vivo

Cyclizine is metabolized to its N-desmethyl derivative, Norcyclizine, which has little antihistamine (H1) activity compared to Cyclizine. After oral administration of Cyclizine, the effect will be produced within 30 minutes, and the maximum effect will be achieved within 1-2 hours, which can last for 4-6 hours. Cyclizine administered orally at a dose of 50 mg alone in healthy adult volunteers produced peak plasma concentrations of approximately 70 ng/mL two hours after dosing. The plasma elimination half-life is about 20 hours.

target

TargetValue
Histamine H1 receptor

IC 50

H1 Receptor

References

[1] Králová J, et, al. The effects of H1-antihistamines on the nitric oxide production by RAW 264.7 cells with respect to their lipophilicity. Int Immunopharmacol. 2009 Jul;9(7-8):990-5. DOI:10.1016/j.intimp.2009.04.005
[2] Church MK, et, al. Inhibition of histamine release from human lung in vitro by antihistamines and related drugs. Br J Pharmacol. 1980 Aug;69(4):663-7. DOI:10.1111/j.1476-5381.1980.tb07919.x
[3] Leza JC, et, al. Effects of antihistaminics on locomotor activity in mice. Comparison with opiate and amphetamine-induced hyperactivity. Gen Pharmacol. 1991;22(2):293-6. DOI:10.1016/0306-3623(91)90451-b

Piperazine, 1-diphenylmethyl-4-methyl-, dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Piperazine, 1-diphenylmethyl-4-methyl-, dihydrochloride Suppliers

China 42 United States 4 Global 46
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5897-18-7, Piperazine, 1-diphenylmethyl-4-methyl-, dihydrochlorideRelated Search:

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