Piperazine, 1-diphenylmethyl-4-methyl-, dihydrochloride
- Product Name
- Piperazine, 1-diphenylmethyl-4-methyl-, dihydrochloride
- CAS No.
- 5897-18-7
- Chemical Name
- Piperazine, 1-diphenylmethyl-4-methyl-, dihydrochloride
- Synonyms
- Cyclizine 2HCl;Marzine hydrochloride;Cyclizine 2hydrochloride;Cyclizine dihydrochloride;Piperazine, 1-benzhydryl-4-methyl-, dihydrochloride;1-Diphenylmethyl-4-methylpiperazine dihydrochloride;Piperazine, 1-diphenylmethyl-4-methyl-, dihydrochloride;Piperazine, 1-(diphenylmethyl)-4-methyl-, hydrochloride (1:2);Piperazine, 1-diphenylmethyl-4-methyl-, dihydrochloride USP/EP/BP
- CBNumber
- CB52497865
- Molecular Formula
- C18H24Cl2N2
- Formula Weight
- 339.30256
- MOL File
- 5897-18-7.mol
Piperazine, 1-diphenylmethyl-4-methyl-, dihydrochloride Property
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- Soluble in DMSO > 10 mM
- form
- Powder
N-Bromosuccinimide Price
- Product number
- 2344AH
- Product name
- Cyclizine2HCl
- Packaging
- 25mg
- Price
- $129
- Updated
- 2021/12/16
- Product number
- B1548
- Product name
- Cyclizine2HCl
- Packaging
- 50mg
- Price
- $146
- Updated
- 2021/12/16
- Product number
- CSN22573
- Product name
- Cyclizine2HCl
- Packaging
- 10mg
- Price
- $36
- Updated
- 2021/12/16
- Product number
- CSN22573
- Product name
- Cyclizine2HCl
- Packaging
- 50mg
- Price
- $61
- Updated
- 2021/12/16
Piperazine, 1-diphenylmethyl-4-methyl-, dihydrochloride Chemical Properties,Usage,Production
Biological Activity
Cyclizine 2HCl is a piperazine derivative with Histamine H1 receptor antagonist activity.
in vitro
Cyclizine is a piperazine histamine H1 receptor antagonist and has anticholinergic and antiemetic properties. It increases lower esophageal sphincter tone and reduces the sensitivity of tortuous organs.
in vivo
Cyclizine is metabolized to its N-desmethyl derivative, Norcyclizine, which has little antihistamine (H1) activity compared to Cyclizine. After oral administration of Cyclizine, the effect will be produced within 30 minutes, and the maximum effect will be achieved within 1-2 hours, which can last for 4-6 hours. Cyclizine administered orally at a dose of 50 mg alone in healthy adult volunteers produced peak plasma concentrations of approximately 70 ng/mL two hours after dosing. The plasma elimination half-life is about 20 hours.
target
| Target | Value |
| Histamine H1 receptor |
Piperazine, 1-diphenylmethyl-4-methyl-, dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Piperazine, 1-diphenylmethyl-4-methyl-, dihydrochloride Suppliers
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