Akt Inhibitor X

Product Name: Akt Inhibitor X
CAS No.: 925681-41-0
Chemical Name: Akt Inhibitor X
Synonyms: 10-NCP;10-DEBC HCl;Akt Inhibitor X;10-NCP (10-DEBC;SVKSJUIYYCQZEC-UHFFFAOYSA-N;N-diethyl-10H-phenoxazine-10-butanamine;2-Chloro-N,N-diethyl-10H-phenoxazine-10-butanamine hydrochloride (1:1)
CBNumber: CB52503238
Molecular Formula: C20H26Cl2N2O
Formula Weight: 381.34
MOL File: 925681-41-0.mol

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Akt Inhibitor X Property

storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Powder
color: White to off-white
Water Solubility: Soluble to 100mM in water or DMSO
Sensitive: Light Sensitive & Hygroscopic

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 124039
Product name: InSolution Akt Inhibitor X - CAS 925681-41-0 - Calbiochem
Packaging: 2mg
Price: $201
Updated: 2024/03/01

Sigma-Aldrich

Product number: 124020
Product name: Akt Inhibitor X - CAS 925681-41-0 - Calbiochem
Packaging: 5mg
Price: $241.8
Updated: 2024/03/01

Alfa Aesar

Product number: J65119
Product name: Akt Inhibitor X
Packaging: 5mg
Price: $190.05
Updated: 2023/01/06

Cayman Chemical

Product number: 14863
Product name: Akt Inhibitor X
Purity: ≥95%
Packaging: 1mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 14863
Product name: Akt Inhibitor X
Purity: ≥95%
Packaging: 5mg
Price: $135
Updated: 2024/03/01

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Akt Inhibitor X Chemical Properties,Usage,Production

Description

Akt functions as a key component in multiple signaling pathways to promote cell survival by mediating resistance to apoptosis. Akt inhibitor X is a cell permeable phenoxazine derivative that suppresses insulin-like growth factor 1 (IGF-1)-stimulated phosphorylation of Akt with an IC₅₀ value of 1-2 μM. This compound has been shown to block IGF-1-stimulated nuclear translocation of Akt in Rh1 cells and to inhibit the growth of Rh1, Rh18, and Rh30 cells with IC₅₀ values of 2-5 μM. Inhibition of Akt phosphorylation by 5 μM of this compound strongly correlates to the inhibition of the downstream targets, mTOR, p70S6 kinase, and S6 ribosomal protein and to an increase in apoptosis.

Uses

Akt Inhibitor X is used as a cell-permeable, reversible, and selective inhibitor of the phosphorylation of Akt and its in vitro kinase activity.

storage

Desiccate at +4°C

References

[1]. janjetovic k, vucicevic l, misirkic m, et al. metformin reduces cisplatin-mediated apoptotic death of cancer cells through ampk-independent activation of akt. european journal of pharmacology, 2011, 651(1): 41-50.
[2]. de abreu la, calixto c, waltero cf, et al. the conserved role of the akt/gsk3 axis in cell survival and glycogen metabolism in rhipicephalus (boophilus) microplus embryo tick cell line bme26. biochimica et biophysica acta (bba)-general subjects, 2013, 1830(3): 2574-2582.
[3]. brunet a, bonni a, zigmond mj, et al. akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor. cell, 1999, 96(6): 857-868.
[4]. pulinilkunnil t, he h, kong d, et al. adrenergic regulation of amp-activated protein kinase in brown adipose tissue in vivo. journal of biological chemistry, 2011, 286(11): 8798-8809.

Akt Inhibitor X Preparation Products And Raw materials

Raw materials

Preparation Products

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Akt Inhibitor X Suppliers

China 41 United Kingdom 1 United States 6 USA 1 Global 49

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

Career Henan Chemica Co

Tel: +86-0371-86658258 +8613203830695
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30239
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
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MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
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Changzhou Furuisi Biotechnology Co., Ltd

Tel: 0519-85524369
Email: 3477467573@qq.com
Country: China
ProdList: 8617
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TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24644
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Shanghai Maclean Biochemical Technology Co., LTD

Tel: 021-50706066 15221275939
Email: shenlinxing@macklin.cn
Country: China
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Nantong QuanYi Biotechnology Co., Ltd

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Email: sales@chemhifuture.com
Country: China
ProdList: 4988
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Shanghai Yifei Biotechnology Co. , Ltd.

Tel: 021-65675885 18964387627
Email: customer_service@efebio.com
Country: China
ProdList: 11974
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925681-41-0, Akt Inhibitor XRelated Search:

Loratadine

Akt Inhibitor X

10-DEBC HCl

2-Chloro-N,N-diethyl-10H-phenoxazine-10-butanamine hydrochloride (1:1)

SVKSJUIYYCQZEC-UHFFFAOYSA-N

10-NCP (10-DEBC

10-NCP

N-diethyl-10H-phenoxazine-10-butanamine

925681-41-0

C20H25ClN2OHCl