3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester
- Product Name
- 3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester
- CAS No.
- 858643-92-2
- Chemical Name
- 3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester
- Synonyms
- tert-butyl 3-acetylpiperidine-1-carboxylate;1-Boc-3-acetylpiperidine;1-Boc-3-acetylpiperidine - [A13489];1,1-Dimethylethyl 3-acetyl-1-piperidinecarboxylate;3-Acetyl-1-piperidinecarboxylic acid tert-butyl ester;3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester;1-Piperidinecarboxylic acid, 3-acetyl-, 1,1-dimethylethyl es...;1-Piperidinecarboxylic acid, 3-acetyl-, 1,1-diMethylethyl ester
- CBNumber
- CB52506466
- Molecular Formula
- C12H21NO3
- Formula Weight
- 227.3
- MOL File
- 858643-92-2.mol
3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester Property
- Boiling point:
- 312.4±35.0 °C(Predicted)
- Density
- 1.052
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -2.40±0.40(Predicted)
- Appearance
- Colorless to off-white Solid
- InChI
- InChI=1S/C12H21NO3/c1-9(14)10-6-5-7-13(8-10)11(15)16-12(2,3)4/h10H,5-8H2,1-4H3
- InChIKey
- IIDISJMZFQAYKG-UHFFFAOYSA-N
- SMILES
- N1(C(OC(C)(C)C)=O)CCCC(C(C)=O)C1
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- B750938
- Product name
- tert-Butyl3-Acetylpiperidine-1-carboxylate
- Packaging
- 500mg
- Price
- $220
- Updated
- 2021/12/16
- Product number
- OR909709
- Product name
- 1-Boc-3-acetyl-piperidine
- Purity
- 97%
- Packaging
- 1g
- Price
- $54
- Updated
- 2021/12/16
- Product number
- A13489
- Product name
- 1-Boc-3-acetylpiperidine
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- 123520
- Product name
- 1-Boc-3-acetylpiperidine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $594
- Updated
- 2021/12/16
- Product number
- OR909709
- Product name
- 1-Boc-3-acetyl-piperidine
- Purity
- 97%
- Packaging
- 5g
- Price
- $166
- Updated
- 2021/12/16
3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester Chemical Properties,Usage,Production
Synthesis
75-16-1
189442-78-2
858643-92-2
Methylmagnesium bromide (1.4 M toluene/THF 75/25, 268 mL) was slowly added dropwise to a solution of 1-Boc-N-methoxy-N-methylpiperidine-3-carboxamide (59 g, 0.22 mol) in tetrahydrofuran (THF, 250 mL) at 0 °C and protected by nitrogen, and the temperature of the reaction was controlled not to exceed 15 °C. After dropwise addition, the reaction mixture was stirred at room temperature for 1 hour. Subsequently, the reaction mixture was slowly poured into an ice-water mixture containing 100 mL of ice-acetic acid. The product was extracted with ether (Et2O) and the organic layer was washed with 5% sodium bicarbonate (NaHCO3) solution. The organic layer was dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure to give tert-butyl 3-acetylpiperidine-1-carboxylate (50 g, quantitative yield).
References
[1] Patent: WO2018/154133, 2018, A1. Location in patent: Page/Page column 48
[2] Patent: US2006/183761, 2006, A1. Location in patent: Page/Page column 27
[3] Journal of Organic Chemistry, 2009, vol. 74, # 5, p. 1932 - 1938
[4] Patent: WO2010/36589, 2010, A1. Location in patent: Page/Page column 62
[5] Patent: WO2012/58127, 2012, A2. Location in patent: Page/Page column 80
3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester Preparation Products And Raw materials
Raw materials
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View Lastest Price from 3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester manufacturers
- Product
- 3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester 858643-92-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2020-01-08
- Product
- 3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester 858643-92-2
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-08