10-Methoxycarbamazepine
- Product Name
- 10-Methoxycarbamazepine
- CAS No.
- 28721-09-7
- Chemical Name
- 10-Methoxycarbamazepine
- Synonyms
- 10-Methoxy-5H-dibenzo[b,f]azepine-5-carboxaMide;Oxcarbazepine-2;P2X4 antagonist-5;OXCARBAZEPINE EP IMP B;Oxcarbazepine Impurity 6;Oxcarbazepine IMpurity C;10-METHOXY CARBAMAZEPINE;Oxcarbazepine impurities3;Oxcarbazepine impurities103;10-methoxy-5h-dibenz(b,f)azepine-5-carboxamide
- CBNumber
- CB5250987
- Molecular Formula
- C16H14N2O2
- Formula Weight
- 266.29
- MOL File
- 28721-09-7.mol
10-Methoxycarbamazepine Property
- Melting point:
- 186-188°C
- Boiling point:
- 468.0±55.0 °C(Predicted)
- Density
- 1.31
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 13.86±0.40(Predicted)
- form
- Solid
- color
- Off-White
- CAS DataBase Reference
- 28721-09-7(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M261260
- Product name
- 10-MethoxyCarbamazepine
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- J40047
- Product name
- 10-Methoxycarbamazepine
- Packaging
- 25mg
- Price
- $48
- Updated
- 2021/12/16
- Product number
- E616
- Product name
- 10-Methoxycarbamazepine
- Packaging
- 1g
- Price
- $58
- Updated
- 2021/12/16
- Product number
- CHM0017561
- Product name
- 10-METHOXY CARBAMAZEPINE
- Purity
- 95.00%
- Packaging
- 25MG
- Price
- $704.55
- Updated
- 2021/12/16
- Product number
- CHM0017561
- Product name
- 10-METHOXY CARBAMAZEPINE
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $1593.9
- Updated
- 2021/12/16
10-Methoxycarbamazepine Chemical Properties,Usage,Production
Chemical Properties
Off-White Solid
Uses
Intermediate in the preparation of dibenzazepine derivatives.
Synthesis
4698-11-7
32315-10-9
28721-09-7
1. 32.67 g (0.11 mol) of triphosgene dissolved in 300 mL of toluene was slowly added dropwise over a period of 6 hours to a mixture of 66.9 g (0.3 mol) of 10-methoxy-5H-dibenzo[b,f]azepine and 34.92 g (0.34 mol) of triethylamine in 800 mL of toluene at a temperature of 10-15 °C. 2. After completion of the reaction ( complete disappearance of 10-methoxy-5H-dibenz[b,f]azepine was confirmed by TLC monitoring), 200 mL of 30% ammonia was slowly added with vigorous stirring for several hours at room temperature.3. After the reaction mixture was layered, the organic phase was separated, the toluene phase was washed with water, and the reaction mixture was subsequently evaporated to dryness under reduced pressure.4. 69.0 g (85% of the theoretical yield) was obtained of a purity greater than 95% of 10-methoxy-5H-dibenz[b,f]azepine. Methoxy-5H-dibenz[b,f]azepine-5-carboxamide.
References
[1] Patent: EP1600443, 2005, A1. Location in patent: Page/Page column 8
10-Methoxycarbamazepine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 10-Methoxycarbamazepine manufacturers
- Product
- 10-Methoxycarbamazepine 28721-09-7
- Price
- US $9.80/KG
- Min. Order
- 1KG
- Purity
- ≥98%
- Supply Ability
- 20 tons
- Release date
- 2020-01-09