3-Mercaptopicolinic Acid, Hydrochloride
- Product Name
- 3-Mercaptopicolinic Acid, Hydrochloride
- CAS No.
- 320386-54-7
- Chemical Name
- 3-Mercaptopicolinic Acid, Hydrochloride
- Synonyms
- 3-Mercaptopicolinic Acid HyHydrochloride;SKF-34288 hydrochloride (3-Mercaptopicolinic acid);SKF 34288,inhibit,3-Mercaptopicolinic acid,SKF34288 hydrochloride,Inhibitor,SKF 34288 hydrochloride,SKF-34288,SKF34288
- CBNumber
- CB52510689
- Molecular Formula
- C6H6ClNO2S
- Formula Weight
- 191.63534
- MOL File
- 320386-54-7.mol
3-Mercaptopicolinic Acid, Hydrochloride Property
- Melting point:
- 200°C dec.
- storage temp.
- Hygroscopic, -20°C Freezer, Under Inert Atmosphere
- solubility
- PBS (pH 7.2): 0.2 mg/ml
- form
- A crystalline solid
- color
- Light yellow to yellow
- Stability:
- Hygroscopic
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 20895
- Product name
- 3-Mercaptopicolinic Acid (hydrochloride)
- Purity
- ≥95%
- Packaging
- 100mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 20895
- Product name
- 3-Mercaptopicolinic Acid (hydrochloride)
- Purity
- ≥95%
- Packaging
- 250mg
- Price
- $86
- Updated
- 2024/03/01
- Product number
- 20895
- Product name
- 3-Mercaptopicolinic Acid (hydrochloride)
- Purity
- ≥95%
- Packaging
- 500mg
- Price
- $161
- Updated
- 2024/03/01
- Product number
- 20895
- Product name
- 3-Mercaptopicolinic Acid (hydrochloride)
- Purity
- ≥95%
- Packaging
- 1g
- Price
- $283
- Updated
- 2024/03/01
- Product number
- M257000
- Product name
- 3-MercaptopicolinicAcidHydrochloride
- Packaging
- 5g
- Price
- $1665
- Updated
- 2021/12/16
3-Mercaptopicolinic Acid, Hydrochloride Chemical Properties,Usage,Production
Description
3-Mercaptopicolinic acid is an inhibitor of gluconeogenesis. In perfused rat livers, gluconeogenesis was inhibited when lactate, pyruvate, or alanine served as substrate, but not with fructose, suggesting phosphoenolpyruvate carboxykinase as the site of inhibition.
Chemical Properties
Light Yellow Solid
Uses
A potent inhibitor of gluconeogenesis.
in vivo
SKF-34288 hydrochloride (37.5-150mg/kg, p.o.) reduces blood glucose in starved rats[6].
SKF-34288 hydrochloride (25 mg/kg, s.c.) neutralizes Salbutamol- mediated hyperglycaemia in rabbits[3].
SKF-34288 hydrochloride (30 and 300 mg/kg, i.p.) reduces Pyruvate-induced blood glucose level in rats[5].
| Animal Model: | Starved rats[6] |
| Dosage: | 37.5, 75 and 150mg/kg |
| Administration: | Oral administration (p.o.) |
| Result: | Showed dose-dependent magnitude and duration of the hypoglycaemic effect. |
storage
Store at -20°C
References
[1] N W DITULLIO. 3-mercaptopicolinic acid, an inhibitor of gluconeogenesis.[J]. Biochemical Journal, 1974, 138 3: 387-394. DOI: 10.1042/bj1380387
[2] B.H. ROBINSON J. O. 3-Mercaptopicolinic acid, a preferential inhibitor of the cytosolic phosphoenolpyruvate carboxykinase[J]. FEBS Letters, 1975, 58 1: Pages 12-15. DOI: 10.1016/0014-5793(75)80214-6
[3] JORGE HIDALGO. Inhibition of Pig Phosphoenolpyruvate Carboxykinase Isoenzymes by 3-Mercaptopicolinic Acid and Novel Inhibitors.[J]. PLoS ONE, 2016: e0159002. DOI: 10.1371/journal.pone.0159002
3-Mercaptopicolinic Acid, Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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