5-Methyl-N-phenyl-2-1H-pyridone-d5 ( Pirfenidone-d5 )

Product Name: 5-Methyl-N-phenyl-2-1H-pyridone-d5 ( Pirfenidone-d5 )
CAS No.: 1020719-62-3
Chemical Name: 5-Methyl-N-phenyl-2-1H-pyridone-d5 ( Pirfenidone-d5 )
Synonyms: AMR69 D5;[2H5]-Pirfenidone;2(1H)-Pyridinone, 5-Methyl-1-phenyl-d5-;2(1H)-Pyridinone, 5-methyl-1-(phenyl-2,3,4,5,6-d5)-;Pirfenidone-d5 (5-Methyl-N-Phenyl-2-1H-Pyridone-d5)?;5-Methyl-N-phenyl-2-1H-pyridone-d5 ( Pirfenidone-d5 );5-methyl-1-(2,3,4,5,6-pentadeuteriophenyl)pyridin-2-one;5-Methyl-1-(phenyl-2,3,4,5,6-d5)-2(1H)-pyridinone;Pirfenidone-d5Q: What is Pirfenidone-d5 Q: What is the CAS Number of Pirfenidone-d5 Q: What is the storage condition of Pirfenidone-d5 Q: What are the applications of Pirfenidone-d5
CBNumber: CB52511343
Molecular Formula: C12H11NO
Formula Weight: 185.23
MOL File: 1020719-62-3.mol

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5-Methyl-N-phenyl-2-1H-pyridone-d5 ( Pirfenidone-d5 ) Property

Melting point:: 104-106°C
storage temp.: -20°C Freezer
solubility: Chloroform (Slightly), Ethanol, Ethyl Acetate, Methanol (Slightly)
form: Solid
color: White to Light Beige
InChI: InChI=1S/C12H11NO/c1-10-7-8-12(14)13(9-10)11-5-3-2-4-6-11/h2-9H,1H3
InChIKey: ISWRGOKTTBVCFA-UHFFFAOYSA-N
SMILES: O=C1C=CC(C)=CN1C1C([H])=C([H])C([H])=C([H])C=1[H]

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 26452
Product name: Pirfenidone-d5
Packaging: 500μg
Price: $106
Updated: 2024/03/01

Cayman Chemical

Product number: 26452
Product name: Pirfenidone-d5
Packaging: 1mg
Price: $178
Updated: 2024/03/01

TRC

Product number: M325898
Product name: 5-Methyl-N-phenyl-2-1H-pyridone-d5(Pirfenidone-d5)
Packaging: 10mg
Price: $1230
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: RDL0007218
Product name: 5-METHYL-N-PHENYL-2-1H-PYRIDONE-D5
Purity: 95.00%
Packaging: 10MG
Price: $1593.9
Updated: 2021/12/16

AK Scientific

Product number: 8703DU
Product name: 5-Methyl-N-phenyl-2-1H-pyridone-d5
Packaging: 1mg
Price: $370
Updated: 2021/12/16

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5-Methyl-N-phenyl-2-1H-pyridone-d5 ( Pirfenidone-d5 ) Chemical Properties,Usage,Production

Description

Pirfenidone-d₅ is intended for use as an internal standard for the quantification of pirfenidone by GC- or LC-MS. Pirfenidone is an orally bioavailable pyridone derivative with antifibrotic, anti-inflammatory, and antioxidant activities. It inhibits TGF-β1-stimulated increases in collagen type I, fibronectin, and Hsp47 expression in A549 lung cancer cells in a concentration-dependent manner. Pirfenidone (300 mg/kg per day) inhibits fibrosis and inhibits increases in collagen content, fibrocyte pool size, and the levels of chemokines CCL2 and CCL12 in lung in a mouse model of pulmonary fibrosis induced by bleomycin . In a mouse model of non-alcoholic steatohepatitis (NASH), pirfenidone inhibits fibrosis and increases in hepatocyte apoptosis, lobular inflammation, and hepatic expression of the fibrosis-related genes Col1a1, Timp1, Tgfb1, Pdgfb, and Fgf2 when administered at a dose of 280 mg/kg but has no effect on steatosis. Pirfenidone also inhibits NADPH-dependent lipid peroxidation in sheep liver microsomes and scavenges hydroxyl radicals (IC₅₀s = ~6 and ~2.5 mM, respectively). Formulations containing pirfenidone have been used in the treatment of idiopathic pulmonary fibrosis.

Chemical Properties

Off-White Solid

Uses

A deuterated metabolite of Pirfenidone, a new drug to treat patients with kidney disease who have diabetes.

5-Methyl-N-phenyl-2-1H-pyridone-d5 ( Pirfenidone-d5 ) Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Methyl-N-phenyl-2-1H-pyridone-d5 ( Pirfenidone-d5 ) Suppliers

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1020719-62-3, 5-Methyl-N-phenyl-2-1H-pyridone-d5 ( Pirfenidone-d5 )Related Search:

Octadecyl methacrylate 2-Methylpropanedioic acid (S)-(+)-Benzyl glycidyl ether p-Tolualdehyde Benzyl alcohol 4'-Hydroxyacetophenone

5-Methyl-N-phenyl-2-1H-pyridone-d5 ( Pirfenidone-d5 )

2(1H)-Pyridinone, 5-Methyl-1-phenyl-d5-

5-Methyl-1-(phenyl-2,3,4,5,6-d<sub>5</sub>)-2(1H)-pyridinone

5-methyl-1-(2,3,4,5,6-pentadeuteriophenyl)pyridin-2-one

AMR69 D5

[2H5]-Pirfenidone

2(1H)-Pyridinone, 5-methyl-1-(phenyl-2,3,4,5,6-d5)-

Pirfenidone-d5 (5-Methyl-N-Phenyl-2-1H-Pyridone-d5)?

Pirfenidone-d5Q: What is Pirfenidone-d5 Q: What is the CAS Number of Pirfenidone-d5 Q: What is the storage condition of Pirfenidone-d5 Q: What are the applications of Pirfenidone-d5

1020719-62-3

Aromatics

Isotope Labelled Compounds

Metabolites