LX-4211
- Product Name
- LX-4211
- CAS No.
- 1018899-04-1
- Chemical Name
- LX-4211
- Synonyms
- Sotagliflozin;β-L-Xylopyranoside,methyl5-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-1-thio-,(5S)-;(5S)-Methyl 5-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-1-thio-beta-L-xylopyranoside Sotagliflozin LP 802034;LX421;CS-1853;LX-4211;SOTA-009;LP 802034;EOS-61381;LX4211/LX-4211
- CBNumber
- CB52516025
- Molecular Formula
- C21H25ClO5S
- Formula Weight
- 424.94
- MOL File
- 1018899-04-1.mol
LX-4211 Property
- Boiling point:
- 607.9±55.0 °C(Predicted)
- Density
- 1.37±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:84.0(Max Conc. mg/mL);197.67(Max Conc. mM)
Ethanol:17.0(Max Conc. mg/mL);40.01(Max Conc. mM) - pka
- 12.87±0.70(Predicted)
- form
- Powder
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H351Suspected of causing cancer
H373May cause damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P281Use personal protective equipment as required.
P308+P313IF exposed or concerned: Get medical advice/attention.
P314Get medical advice/attention if you feel unwell.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 19141
- Product name
- Sotagliflozin
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 19141
- Product name
- Sotagliflozin
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $161
- Updated
- 2024/03/01
- Product number
- 19141
- Product name
- Sotagliflozin
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $283
- Updated
- 2024/03/01
- Product number
- 19141
- Product name
- Sotagliflozin
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $573
- Updated
- 2024/03/01
- Product number
- A3567
- Product name
- LX-4211
- Packaging
- 5mg
- Price
- $165
- Updated
- 2021/12/16
LX-4211 Chemical Properties,Usage,Production
Uses
Sotagliflozin is used for the treatment of patients with type 1 diabetes mellitus.
Clinical Use
Two of the current SGLT-2 inhibitors (canagliflozin and LX-4211) have effects on SGLT-1. LX-4211 is a dual SGLT1/2 inhibitor and higher doses of canagliflozin transiently inhibit SGLT-1 in the gut due to high canagliflozin concentrations within the intestinal lumen during the period of drug absorption.
Synthesis
Sotagliflozin is a dual SGLT-1/SGLT-2 inhibitor which is currently under development by Lexicon Pharmaceuticals (phase III). It follows a similar strategy to ertugliflozin, i.e. aryl addition on an acyclic precursor. The synthesis starts from L-xylose 53, and the aryl moiety (same aryl moiety as for dapagliflozin) is introduced on an amide derivative (morpholine amide 54) via Grignard addition. A subsequent transformation leads to the sotagliflozin (Scheme 10). The overall yield of the synthesis is around 30%.
Sotagliflozin synthesis
LX-4211 Preparation Products And Raw materials
Raw materials
Preparation Products
LX-4211 Suppliers
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View Lastest Price from LX-4211 manufacturers
- Product
- LX-4211 1018899-04-1
- Price
- US $999.00-900.00/kg
- Min. Order
- 0.0010000000474974513kg
- Purity
- 99%
- Supply Ability
- 5000
- Release date
- 2024-08-08
- Product
- Sotagliflozin,LX-4211, LP-802034, LX4211, LP802034 1018899-04-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%，single impurity＜0.1
- Supply Ability
- 1 ton
- Release date
- 2024-01-04
- Product
- LX-4211 1018899-04-1
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 1000
- Release date
- 2024-06-11